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Compositions for regenerating defective or absent myocardium

  • US 8,735,155 B1
  • Filed: 09/27/2013
  • Issued: 05/27/2014
  • Est. Priority Date: 07/15/2005
  • Status: Active Grant
First Claim
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1. An injectable graft composition for myocardial tissue regeneration, said composition comprising an acellular extracellular matrix (ECM) from a mammalian tissue source comprising stomach submucosa, said ECM comprising endogenous transforming growth factor beta (TGF-β

  • ) and fibroblast growth factor-2 (FGF-2), said ECM further comprising an exogenously added glycosaminoglycan (GAG) protein, said GAG protein comprising at least 0.1% by weight of said composition, said GAG protein being linked to said ECM, wherein said GAG protein stimulates angiogenic effects of FGF-2 and interacts with TGF-β

    to control matrix formation and remodeling, wherein, when said composition is administered to damaged or diseased cardiovascular tissue, said composition induces stem cell proliferation and differentiation of stem cells into cardiomyocytes.

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