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Optimized Fc Variants

  • US 8,735,547 B2
  • Filed: 04/25/2013
  • Issued: 05/27/2014
  • Est. Priority Date: 09/27/2002
  • Status: Expired due to Term
First Claim
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1. A protein comprising an Fc variant of a human IgG1 Fc polypeptide, wherein said Fc variant comprises an amino acid modification in the Fc region of said parent Fc polypeptide at position 243, wherein said protein exhibits altered binding affinity to an Fcγ

  • receptor (Fcγ

    R) as compared to a parent polypeptide, wherein numbering is according to the EU index.

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