Phenoxazine derivatives and methods of use thereof

• US 8,735,575 B2
• Filed: 08/01/2011
• Issued: 05/27/2014
• Est. Priority Date: 07/30/2010
• Status: Active Grant

• Current Assignee: Washington University In St Louis
• Original Assignee: Washington University In St Louis
• Inventors: Zipfel, Gregory, Han, Byung, Mach, Robert, Chu, Wenhau
• Primary Examiner(s): Habte, Kahsay
• Application Number:
  US13/195,344
• Publication Number:
  US 20120035359A1
• Time in Patent Office: 1,030 Days
• Field of Search: 544/102
• US Class Current: 544/102
• CPC Class Codes: C07D 265/38 [b, e]-condensed with two six-membered rings
• CPC Class Codes: C07D 413/12 linked by a chain containing hetero atoms as chain links

Abstract

The present invention encompasses phenoxazine derivatives and methods of use thereof.

Claims

1. A compound of formula (IV):

2. The compound of claim 1, wherein R¹⁰ is a halogen.

3. The compound of claim 1, wherein R¹⁰ is an alkenyl group.

4. The compound of claim 1, wherein R¹⁰ is an alkynyl group.

5. The compound of claim 1, wherein R¹ is O, R² is O, R⁹ is (CH₂)_g, wherein g is an integer from 1 to 4, and R¹⁰ is a halogen.

6. The compound of claim 1, wherein R¹ is O, R² is O, R⁹ is (CH₂)₂, and R¹⁰ is halogen.

7. The compound of claim 1, wherein R¹ is O, R² is O, R⁹ is (CH₂)₂, and R¹⁰ is F.

8. The compound of claim 1, wherein R¹ is O, R² is O, R⁹ is (CH₂)_g, wherein g is an integer from 1 to 10, and R¹⁰ is halogen.

9. The compound of claim 1, wherein R¹ is O, R² is O, R⁹ is (CH₂)_g, wherein g is an integer from 1 to 10, and R¹⁰ is F.