Real-time in vivo radiation dosimetry using scintillation detectors

• US 8,735,828 B2
• Filed: 01/07/2010
• Issued: 05/27/2014
• Est. Priority Date: 01/08/2009
• Status: Active Grant

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Beddar, A. Sam, Briere, Tina Marie, Archambault, Louis
• Primary Examiner(s): Porta, David
• Assistant Examiner(s): Malevic, Djura
• Application Number:
  US13/143,567
• Publication Number:
  US 20120068075A1
• Time in Patent Office: 1,601 Days
• Field of Search: 250/362
• US Class Current: 250/362
• CPC Class Codes: A61N 2005/1072 taking into account movement of the target
• CPC Class Codes: A61N 5/1048 Monitoring, verifying, controlling systems and methods
• CPC Class Codes: A61N 5/1071 for verifying the dose delivered by the treatment plan
• CPC Class Codes: G01T 1/023 Scintillation dose-rate meters
• CPC Class Codes: G01T 1/161 Applications in the field of nuclear medicine, e.g. in vivo counting apparatus for radiation diagnosis A61B6/00

Abstract

Apparatus and methods for measuring radiation levels in vivo in real time. Apparatus and methods include a scintillating material coupled to a retention member.

Claims

1. An apparatus configured to measure radiation levels in vivo, the apparatus comprising:

a retention member configured to retain the apparatus in a location in vivo;

a scintillating material configured to emit light when irradiated;

an optical guide configured to transport light emitted from the scintillating material;

a photodetector configured to detect light emitted from the scintillating material and transported by the optical guide; and

a data analyzer configured to analyze an output from the photodetector and configured to determine if the photodetector has been exposed to a threshold level of radiation therapy for cancer treatment.

2. The apparatus of claim 1 wherein the retention member is inflatable.

3. The apparatus of claim 1 wherein the scintillating material is configured as an optical fiber.

4. The apparatus of claim 1 wherein the scintillating material is coupled to the retention member.

5. The apparatus of claim 1 wherein the scintillating material is arranged parallel to a primary axis of the retention member.

6. The apparatus of claim 1 wherein the scintillating material is formed as a plurality of optical fibers arranged parallel to a primary axis of the retention member and extending and wherein one or more of the optical fibers extend different lengths along the retention member.

7. The apparatus of claim 1 further comprising radiopaque markers coupled to the retention member.

8. The apparatus of claim 7 wherein the radiopaque markers are embedded in the retention member.

9. The apparatus of claim 7 wherein the radiopaque markers are configured parallel to a primary axis of the retention member.

10. The apparatus of claim 7 wherein the radiopaque markers are configured perpendicular to a primary axis of the retention member.

11. The apparatus of claim 1 wherein the retention member is configured as an inflatable balloon with an external shape that conforms to a prostate of a patient.

12. The apparatus claim 1 wherein the retention member has a cross-section that is generally elliptical and has a greater width than height and comprises an indentation along the width.

13. The apparatus of either claim 12 wherein the retention member comprises an insertion rod coupled to a plurality of radiopaque markers and the scintillating material.

14. The apparatus of claim 1 wherein the retention member comprises a flexible coupling member coupled to a plurality of detectors comprising scintillating material.

15. The apparatus of claim 1 wherein the retention member comprises a flexible coupling member coupled to a plurality of radiopaque markers.

16. The apparatus of claim 1 wherein the retention member is configured as a rigid probe.

17. The apparatus of claim 16 further comprising a plurality of radiopaque markers and a plurality of detectors comprising scintillating material.

18. The apparatus of claim 1 wherein the scintillating material comprises a wavelength shifting member.

19. The apparatus of claim 1 wherein the retention member is an ultrasonic probe.

20. An apparatus configured to measure radiation levels in vivo, the apparatus comprising:

a retention member configured to retain the apparatus in a location in vivo;

a scintillating material configured to emit light when irradiated;

an optical guide configured to transport light emitted from the scintillating material; and

a photodetector configured to detect light emitted from the scintillating material and transported by the optical guide wherein the scintillating material is wrapped around the retention member to form a spiral about a primary axis of the retention member to provide information about a radiation dose delivered to all or part of the surface of the retention member.

21. An apparatus configured to measure radiation levels in vivo, the apparatus comprising:

a retention member configured to retain the apparatus in a location in vivo;

a scintillating material configured to emit light when irradiated;

an optical guide configured to transport light emitted from the scintillating material; and

a photodetector configured to detect light emitted from the scintillating material and transported by the optical guide wherein the scintillating material is wrapped around the retention member to form an annular arrangement about a primary axis of the retention member to provide information about a radiation dose delivered to the all or part of the surface of the retention member.

22. A method of measuring radiation levels in vivo, the method comprising:

providing a scintillating material, wherein the scintillating material is configured to emit light when exposed to radiation;

coupling the scintillating material to a retention member;

securing the retention member in a specific location in vivo;

exposing the specific location and the scintillating material to a threshold level of radiation therapy for cancer treatment;

measuring the amount of light emitted from the scintillating material; and

calculating the level of radiation at the specific location based on the amount of light emitted from the scintillating material.

23. The method of claim 22 wherein securing the retention member to the specific location in vivo comprises inflating the retention member.

24. The method of claim 22 wherein coupling the scintillating material to the retention member comprises coupling the scintillating material to a cover and placing the cover over the retention member.

25. The method of claim 22 wherein coupling the scintillating material to the retention member comprises inserting the scintillating material into a channel of the retention member.

26. The method of claim 22 wherein calculating the level of radiation at the specific location based on the amount of light emitted from the scintillating material is performed in real time.

27. The method of claim 22 wherein measuring the amount of light emitted from the scintillating material comprises transferring light from the scintillating material to a photodetector via an optical coupling and a fiber light guide.

28. The method of claim 27 wherein measuring the amount of light emitted from the scintillating material comprises transferring light emitted from the scintillating material to a wavelength shifting member.

29. The method of claim 28 further comprising comparing the calculated level of radiation at the specific location to a predetermined level of radiation.

30. The method of claim 29 further comprising automatically stopping the exposure of radiation when the level of calculated level of radiation at the specific location is equal to the predetermined level of radiation.

31. The method of claim 22 further comprising:

providing one or more radiopaque markers coupled to the retention member, wherein the one or more radiopaque markers are configured to be visible when the retention member is exposed to radiation in vivo.

32. The method of claim 31 wherein the one or more radiopaque markers extend parallel to a primary axis of the retention member.

33. The method of claim 31 wherein the one or more radiopaque markers extend perpendicular to a primary axis of the retention member.

34. The method of claim 31 wherein the one or more radiopaque markers are configured to allow the longitudinal and rotational position of the retention member to be determined when the retention member is exposed to radiation in vivo.

37. The method of claim 23 A method of measuring radiation levels in vivo, the method comprising:

providing a scintillating material, wherein the scintillating material is configured to emit light when exposed to radiation;

coupling the scintillating material to a retention member;

securing the retention member in a specific location in vivo;

exposing the specific location and the scintillating material to radiation;

measuring the amount of light emitted from the scintillating material; and

calculating the level of radiation at the specific location based on the amount of light emitted from the scintillating material wherein the scintillating material is configured as one or more fibers, and wherein coupling the scintillating material to the retention member comprises arranging the one or more fibers in a spiral arrangement about a primary axis of the retention member.

35. A method of measuring radiation levels in vivo, the method comprising:

providing a scintillating material, wherein the scintillating material is configured to emit light when exposed to radiation;

coupling the scintillating material to a retention member;

securing the retention member in a specific location in vivo;

exposing the specific location and the scintillating material to radiation;

measuring the amount of light emitted from the scintillating material; and

calculating the level of radiation at the specific location based on the amount of light emitted from the scintillating material wherein coupling the scintillating material to the retention member comprises wrapping the scintillating material around the retention member.

36. A method of measuring radiation levels in vivo, the method comprising:

providing a scintillating material, wherein the scintillating material is configured to emit light when exposed to radiation;

coupling the scintillating material to a retention member;

securing the retention member in a specific location in vivo;

exposing the specific location and the scintillating material to radiation;

measuring the amount of light emitted from the scintillating material; and

calculating the level of radiation at the specific location based on the amount of light emitted from the scintillating material wherein the scintillating material is configured as one or more fibers, and wherein coupling the scintillating material to the retention member comprises arranging the one or more fibers in an annular arrangement about a primary axis of the retention member.