Equilibrium non-consuming fluorescence sensor for real time intravascular glucose measurement
First Claim
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1. A sensor for determining glucose concentration comprising:
- an optical fiber comprising a non-consuming, equilibrium fluorescence chemical indicator system disposed along a distal region of the optical fiber, the chemical indicator system comprising an HPTS-triCysMA fluorophore that generates a fluorescence emission signal when excited by light and a glucose binding moiety in close enough proximity to the fluorophore to interact with the fluorophore and modulate the fluorescence emission signal, wherein the extent of modulation of the fluorescence emission signal by the glucose binding moiety is related to the amount of glucose bound to the glucose binding moiety;
a light source; and
a detector.
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Abstract
Embodiments of the present invention relates to analyte sensors. In particular, the preferred embodiments of the present invention relate to non-consuming intravascular glucose sensors based on fluorescence chemistry.
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19 Claims
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1. A sensor for determining glucose concentration comprising:
- an optical fiber comprising a non-consuming, equilibrium fluorescence chemical indicator system disposed along a distal region of the optical fiber, the chemical indicator system comprising an HPTS-triCysMA fluorophore that generates a fluorescence emission signal when excited by light and a glucose binding moiety in close enough proximity to the fluorophore to interact with the fluorophore and modulate the fluorescence emission signal, wherein the extent of modulation of the fluorescence emission signal by the glucose binding moiety is related to the amount of glucose bound to the glucose binding moiety;
a light source; and
a detector. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
- an optical fiber comprising a non-consuming, equilibrium fluorescence chemical indicator system disposed along a distal region of the optical fiber, the chemical indicator system comprising an HPTS-triCysMA fluorophore that generates a fluorescence emission signal when excited by light and a glucose binding moiety in close enough proximity to the fluorophore to interact with the fluorophore and modulate the fluorescence emission signal, wherein the extent of modulation of the fluorescence emission signal by the glucose binding moiety is related to the amount of glucose bound to the glucose binding moiety;
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