Clustering of recorded patient neurological activity to determine length of a neurological event
First Claim
1. A method for updating a therapy parameter that is associated with a treatment therapy by a medical device during a neurological event of a nervous system disorder, the method comprising:
- (a) determining, with a processor, a first detection cluster corresponding to the neurological event based on determining an inter-detection interval between detections in a neurological signal;
(b) applying one or more groups of applications of a treatment therapy during the first detection cluster, wherein each group of applications of the treatment therapy comprises at least one application of the treatment therapy; and
(c) adjusting the therapy parameter for each mth successive group of applications of the treatment therapy during the first detection cluster, wherein m is a first positive integer.
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Abstract
Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each nth detection cluster.
157 Citations
36 Claims
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1. A method for updating a therapy parameter that is associated with a treatment therapy by a medical device during a neurological event of a nervous system disorder, the method comprising:
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(a) determining, with a processor, a first detection cluster corresponding to the neurological event based on determining an inter-detection interval between detections in a neurological signal; (b) applying one or more groups of applications of a treatment therapy during the first detection cluster, wherein each group of applications of the treatment therapy comprises at least one application of the treatment therapy; and (c) adjusting the therapy parameter for each mth successive group of applications of the treatment therapy during the first detection cluster, wherein m is a first positive integer. - View Dependent Claims (2, 3, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 20)
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4. The method of 3, step (c) further comprises the step of:
(ii) limiting the therapy parameter to be less than a first predetermined threshold.
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5. The method of 3, wherein step (c) further comprises the step of:
(ii) limiting the therapy parameter so that a corresponding current density is less than a pre-specified current density. - View Dependent Claims (6, 7, 19)
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21. A medical device configured to update a therapy parameter that is associated with a treatment therapy during a neurological event of a nervous system disorder, the medical device comprising:
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a configuration of monitoring elements; a delivery module that delivers the treatment therapy to a patient with the nervous system disorder; and a processor that is coupled to the configuration of monitoring elements, the processor configured to perform the steps of; (a) determining a first detection cluster corresponding to the neurological event based on determining an inter-detection interval between detections in a neurological signal; (b) applying one or more groups of applications of a treatment therapy during the first detection cluster, wherein each group of applications of the treatment therapy comprises at least one application of the treatment therapy; and (c) adjusting the therapy parameter for each mth successive group of applications of the treatment therapy during the first detection cluster, wherein m is a first positive integer. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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Specification