Treatment of vascular occlusions using ultrasonic energy and microbubbles
First Claim
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1. A method of treating a vascular occlusion located at a treatment site within a patient'"'"'s vasculature, the method comprising:
- positioning an ultrasound assembly at the treatment site;
delivering a diluted microbubble-therapeutic compound from the ultrasound assembly to the vascular occlusion, wherein the diluted microbubble-therapeutic compound has;
(1) an initial microbubble concentration of less than or equal to approximately 1% by volume of an original microbubble concentration at the deliverance to the ultrasound assembly;
or(2) an effective microbubble concentration of less than or equal to approximately 0.01% of the original microbubble concentration at deliverance into the vascular occlusion; and
delivering ultrasonic energy from the ultrasound assembly to the vascular occlusion concurrently.
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Abstract
In one embodiment of the present invention, a method of treating a vascular occlusion located at a treatment site within a patient'"'"'s vasculature comprises positioning an ultrasound catheter at the treatment site. The method further comprises delivering a microbubble-therapeutic compound from the ultrasound catheter to the vascular occlusion during a first treatment phase.
304 Citations
11 Claims
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1. A method of treating a vascular occlusion located at a treatment site within a patient'"'"'s vasculature, the method comprising:
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positioning an ultrasound assembly at the treatment site; delivering a diluted microbubble-therapeutic compound from the ultrasound assembly to the vascular occlusion, wherein the diluted microbubble-therapeutic compound has; (1) an initial microbubble concentration of less than or equal to approximately 1% by volume of an original microbubble concentration at the deliverance to the ultrasound assembly;
or(2) an effective microbubble concentration of less than or equal to approximately 0.01% of the original microbubble concentration at deliverance into the vascular occlusion; and delivering ultrasonic energy from the ultrasound assembly to the vascular occlusion concurrently. - View Dependent Claims (2, 3, 4, 5)
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6. A method of treating a vascular occlusion located at a treatment site within a patient'"'"'s vasculature, the method comprising:
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passing an ultrasound assembly through the patient'"'"'s vasculature to the treatment site, wherein the ultrasound assembly comprises at least one distal fluid delivery port and at least one ultrasound radiating member; delivering a microbubble-therapeutic compound at the proximal end of fluid delivery port from the distal fluid delivery port that is not acoustically isolated to the vascular occlusion of about 1% of original concentration wherein the initial microbubble concentration in microbubble-therapeutic compound concentration is diluted to less than or equal to approximately 1% by volume, and the final concentration at the point of delivery to the vascular occlusion is further reduced to 0.01% of the initial microbubble concentration after passing the not acoustically isolated distal tip; and delivering ultrasonic energy from the ultrasound assembly to the vascular occlusion concurrent to delivering the microbubble-therapeutic compound. - View Dependent Claims (7, 8, 9, 10, 11)
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Specification