Injection methods using a servo-controlled needle-free injector

• US 8,740,838 B2
• Filed: 10/07/2011
• Issued: 06/03/2014
• Est. Priority Date: 10/07/2010
• Status: Active Grant

• Current Assignee: Massachusetts Institute of Technology
• Original Assignee: Massachusetts Institute of Technology
• Inventors: Hemond, Brian D., Hunter, Ian W., Taberner, Andrew J., Wendell, Dawn M., Hogan, N. Catherine
• Primary Examiner(s): SCHMIDT, EMILY LOUISE
• Application Number:
  US13/269,421
• Publication Number:
  US 20120089114A1
• Time in Patent Office: 970 Days
• Field of Search: 604 57- 64, 604 68- 72, 604/503
• US Class Current: 604/68
• CPC Class Codes: A61M 2205/3331 Pressure; Flow
• CPC Class Codes: A61M 2205/3358 Measuring barometric pressure, e.g. for compensation
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/8287 operated by an external magnetic or electromagnetic field
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
• CPC Class Codes: A61M 5/46 having means for controlling depth of insertion
• CPC Class Codes: A61M 5/486 Indicating injection pressure

Abstract

A method for injecting a substance through a biological body surface includes providing a needle-free transdermal transport device configured to inject the substance through the surface. The substance is injected into the biological body with the transport device while a parameter of the injection is sensed and a servo-controller is used to dynamically adjust at least one injection characteristic based on the sensed parameter. The substance is injected for (i) a first time period during which a first portion of a volume of the substance is injected at a first injection pressure, and (ii) a second time period during which a remainder of the volume of the substance is injected at a second injection pressure. A viscosity of the substance may be determined, and a pressure calculated for injecting the substance based on the viscosity. The substance may be injected with the transport device by using the calculated pressure.

Claims

1. A method for injecting a substance through a surface of a biological body, the method comprising the steps of:

providing a needle-free transdermal transport device configured to inject the substance through the surface of the biological body; and

injecting the substance into the biological body with the transport device while

(i) sensing a parameter associated with the injection, the parameter comprising at least one of deformation of an ampoule disposed on the needle-free transdermal transport device and sound of substance impinging on the biological body; and

(ii) using a servo-controller to dynamically adjust at least one injection characteristic based on the sensed parameter,

wherein the substance is injected for (i) a first time period during which a first portion of a volume of the substance is injected at the first injection pressure, and (ii) a second time period during which a remainder of the volume of the substance is injected at a second injection pressure.

2. The method of claim 1, wherein sensing the parameter further comprises sensing at least one of injection pressure, sensed pressure within the transport device, position, volume, mechanical impedance, force, current, and voltage.

3. The method of claim 1, wherein the at least one injection characteristic is selected from the group consisting of depth of injection and volume of injected substance.

4. The method of claim 1, further comprising, prior to injecting the substance, pre-programming the transport device with a jet velocity waveform.

5. The method of claim 4, wherein the jet velocity waveform comprises a first jet velocity, the first time period, a second follow-through velocity, and the volume.

6. The method of claim 5, wherein the second time period is determined by the needle-free transdermal transport device.

7. The method of claim 1, wherein the needle-free transdermal transport device comprises a coil, and the injection characteristic is dynamically controlled on the basis of measured coil displacement.

8. The method of claim 7, wherein the needle-free transdermal transport device comprises a position sensor, and coil displacement is measured by sensing the coil displacement with the position sensor.

9. The method of claim 1, wherein the sensed parameter is deformation of an ampoule disposed on the needle-free transdermal transport device.

10. The method of claim 1, wherein the sensed parameter is sound of substance impinging on the biological body.

11. A control system for a needle-free transdermal transport device configured to inject a substance through a surface of a biological body, the control system comprising:

a sensor for sensing a parameter of the injection, the sensor selected from the group consisting of a sensor that senses deformation of an ampoule disposed on the needle-free transdermal transport device and a sensor that senses sound of substance impinging on the biological body; and

a servo-controller to dynamically adjust at least one injection characteristic based on the sensed parameter,

wherein the sensor and the servo-controller control the injection of the substance such that the substance is injected for (i) a first time period during which a first portion of a volume of the substance is injected at a first injection pressure, and (ii) a second time period during which a remainder of the volume of the substance is injected at a second injection pressure.

12. The control system of claim 11, wherein the sensor is a sensor that senses deformation of an ampoule disposed on the needle-free transdermal transport device.

13. The control system of claim 11, wherein the sensor is a sensor that senses sound of substance impinging on the biological body.

14. The control system of claim 12, wherein the sensor is a strain gauge.

15. The control system of claim 13, wherein the sensor is an acoustic sensor or transducer.