Device and methods for treating paranasal sinus conditions

• US 8,740,839 B2
• Filed: 09/15/2010
• Issued: 06/03/2014
• Est. Priority Date: 04/04/2005
• Status: Active Grant

• Current Assignee: Intersect ENT, Inc. (Medtronic Plc)
• Original Assignee: Intersect ENT, Inc. (Medtronic Plc)
• Inventors: Eaton, Donald J., Tice, Thomas R., Downie, David B., Arensdorf, Patrick A., Brenneman, Rodney A., Biggs, Danielle L.
• Primary Examiner(s): Flick, Jason
• Assistant Examiner(s): MEDWAY, SCOTT J
• Application Number:
  US12/883,071
• Publication Number:
  US 20110004194A1
• Time in Patent Office: 1,357 Days
• Field of Search: 604/101.01, 604/94.01, 604/514, 606/199
• US Class Current: 604/94.01
• CPC Class Codes: A61B 17/24 for use in the oral cavity, larynx, bronchial passages or nose for medical inspection of cavities or tubes in the body A61B1/00; Tongue scrapers
• CPC Class Codes: A61F 2/186 Nose parts
• CPC Class Codes: A61K 31/573 substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
• CPC Class Codes: A61K 31/58 containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin digitoxin A61K31/7048
• CPC Class Codes: A61K 47/14 Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• CPC Class Codes: A61K 47/34 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers A61K47/10 takes precedence
• CPC Class Codes: A61K 9/0043 Nose
• CPC Class Codes: A61K 9/1647 Polyesters, e.g. poly(lactide-co-glycolide)
• CPC Class Codes: A61K 9/70 Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug hollow drug-filled fibres A61K9/0092
• CPC Class Codes: A61M 29/00 Dilators with or without means for introducing media, e.g. remedies instruments for performing visual medical inspections of cavities or tubes of the body A61B1/00
• CPC Class Codes: A61P 27/16 Otologicals
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Described here are paranasal sinus devices for treating paranasal sinus conditions. The devices include a cavity member, ostial member, and nasal portion. One or more of the cavity member, ostial member, and nasal portion may deliver an active agent for sustained release to treat the paranasal sinus condition. Exemplary paranasal sinus conditions are sinus inflammation due to functional endoscopic sinus surgery (FESS) and rhinosinusitis.

Claims

1. A fully-implantable paranasal sinus device comprising:

a tube-like ostial member shaped and sized to fit within a paranasal sinus ostium, wherein the ostial member comprises a lumen extending therethrough and a plurality of apertures along the length of the ostial member;

a nasal portion configured to extend into a nasal cavity, the nasal portion comprising a nasal plate connected to the ostial member and sized to fit within the nasal cavity, the nasal plate comprising an aperture in communication with a lumen of the ostial member; and

a cavity member shaped and sized to fit within a paranasal sinus cavity.

2. The paranasal sinus device of claim 1 further comprising a coating configured to release one or more active agents therefrom.

3. The paranasal sinus device of claim 2 wherein the one or more active agents comprises mometasone furoate.

4. The paranasal sinus device of claim 1 wherein the paranasal sinus device is configured to biodegrade.

5. The paranasal sinus device of claim 1 wherein the cavity member comprises one or more filaments.

6. A method for treating a sinus condition comprising:

advancing a tube-like ostial member of a fully-implantable paranasal sinus device into a paranasal sinus ostium such that a nasal portion of the paranasal sinus device extends into a nasal cavity outside the paranasal sinus ostium and a cavity member of the paranasal sinus device contacts a sinus cavity wall, wherein the ostial member comprises a lumen extending therethrough and a plurality of apertures along the length of the ostial member and the nasal portion comprises a nasal plate connected to the ostial member and positioned in the nasal cavity, the nasal plate comprising an aperture in communication with a lumen of the ostial member.

7. The method of claim 6 further comprising directly viewing the paranasal sinus ostium.

8. The method of claim 6 wherein the paranasal sinus device is advanced using a sinus inserter.

9. The method of claim 6 wherein the paranasal sinus device is configured to biodegrade.

10. The method of claim 9 wherein the paranasal sinus device comprises one or more biodegradable polymers.

11. The method of claim 6 wherein the paranasal device is configured to release one or more active agents therefrom.

12. The method of claim 11 wherein the one or more active agents comprises mometasone furoate.

13. The method of claim 6 wherein the paranasal sinus device comprises a radiopaque marker.