Medical device with drug delivery member

• US 8,740,844 B2
• Filed: 08/20/2003
• Issued: 06/03/2014
• Est. Priority Date: 08/20/2003
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Freyman, Toby, Mickley, Timothy J., Palasis, Maria J., Naimark, Wendy
• Primary Examiner(s): Lucchesi, Nicholas
• Assistant Examiner(s): CHANDER, DIVA KAKAR
• Application Number:
  US10/645,653
• Publication Number:
  US 20050043678A1
• Time in Patent Office: 3,940 Days
• Field of Search: 604/103, 604/103.1, 604/103.2, 604/103.01
• US Class Current: 604/103.01
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 25/1029 Production methods of the balloon members, e.g. blow-moulding, extruding, deposition or by wrapping a plurality of layers of balloon material around a mandril
• CPC Class Codes: A61M 29/02 Dilators made of swellable material balloon catheters for angioplasty A61M25/104

Abstract

The present invention generally relates to a medical device for delivering a therapeutic agent to an internal portion of a patient'"'"'s body. The medical device includes a shaft and a self-expanding delivery member in operative communication with the shaft. The delivery member is shaped from a porous material that is capable of releasing a therapeutic agent to an internal portion of a patient'"'"'s body. The medical device further includes a therapeutic agent delivery lumen in fluid communication with the delivery member to fluidly connect the delivery member with a therapeutic agent source. A retention member may also be provided to selectively collapse the delivery member.

Claims

1. A medical device for delivering a therapeutic agent to an internal portion of a patient'"'"'s body, the medical device comprising:

a shaft;

a self-expanding delivery member in operative communication with the shaft, the delivery member having a proximal end and a distal end and being shaped in a continuous solid cylindrical configuration from a porous material capable of (i) releasing the therapeutic agent to the internal portion of the patient'"'"'s body and (ii) being in a collapsed state;

a therapeutic agent delivery lumen defined by a lumen wall, wherein the therapeutic agent delivery lumen is in fluid communication with the delivery member for fluidly connecting the delivery member with a therapeutic agent source;

a retention member in operative communication with the delivery member, the retention member being configured and arranged to selectively collapse the delivery member; and

a mechanism capable of applying negative pressure through the therapeutic agent delivery lumen to remove fluid from the delivery member,

wherein the delivery member expands from a collapsed state to a pre-determined diameter upon retraction of the retention member, and

wherein the delivery member expands without absorption of a liquid.

2. The medical device of claim 1, wherein the therapeutic agent source is a Luer syringe.

3. The medical device of claim 2, wherein the Luer syringe is the source of the negative pressure.

4. The medical device of claim 2, wherein the delivery member is formed of carboxymethyl cellulose, polyacrylic acid, carboxymethyl starch, chitosan, potassium polymetaphosphates, polyethylene, nylon, polyurethane, PEBAX, silicone, alginate, cotton, polymers cross-linked during phase transition, collagen foams, PLA, PLGA, or PGA.

5. The medical device of claim 1, wherein the porous material is degradable.

6. The medical device of claim 1, wherein the delivery member is shaped from a self-expanding material that is configured and sized to contact at least a portion of a target body lumen when the delivery member is in an expanded state.

7. The medical device of claim 6, wherein the delivery member is configured and sized to self-expand to at least partially conform to the internal contour of the target body lumen when the delivery member is in an expanded state.

8. The medical device of claim 1, further comprising a distal end cap disposed at the distal end of the delivery member, the distal end cap at least partially sealing the distal end of the delivery member.

9. The medical device of claim 1, further comprising a proximal end cap disposed at the proximal end of the delivery member, the proximal end cap at least partially sealing the proximal end of the delivery member.

10. The medical device of claim 1, wherein the proximal end of the delivery member has a tapered configuration when the delivery member is in an expanded condition.

11. The medical device of claim 1, wherein the distal end of the delivery member has a tapered configuration when the delivery member is in an expanded condition.

12. The medical device of claim 1, wherein the delivery member has a length between about 5 mm and about 40 mm.

13. The medical device of claim 1, wherein the shaft has a wire lumen therethrough for receiving a guide wire.

14. The medical device of claim 13, wherein the wire lumen is located within the delivery lumen.

15. The medical device of claim 13, wherein the wire lumen extends into the delivery member.

16. The medical device of claim 1, wherein the mechanism capable of applying negative pressure is a Luer syringe.