Lung volume reduction devices, methods, and systems

• US 8,740,921 B2
• Filed: 09/14/2012
• Issued: 06/03/2014
• Est. Priority Date: 03/13/2006
• Status: Expired due to Fees

• Current Assignee: Ekos LLC (Boston Scientific Corporation)
• Original Assignee: PneumRx, Inc. (Boston Scientific Corporation)
• Inventors: Mathis, Mark L., Thompson, David, Aronson, Nathan, Wu, Patrick
• Primary Examiner(s): ANDERSON, GREGORY A
• Application Number:
  US13/618,822
• Publication Number:
  US 20130096603A1
• Time in Patent Office: 627 Days
• Field of Search: 606/157, 606/151, 623/23.64, 623/23.65
• US Class Current: 606/157
• CPC Class Codes: A61B 1/2676 Bronchoscopes
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12031 complete occlusion
• CPC Class Codes: A61B 17/12104 in an air passage
• CPC Class Codes: A61B 17/12131 characterised by the type of occluding device
• CPC Class Codes: A61B 17/12145 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/122 Clamps or clips , e.g. for the umbilical cord for the vas deferens A61F6/206
• CPC Class Codes: A61B 2017/00477 Coupling A61B2017/0046 takes precedence
• CPC Class Codes: A61B 2017/00809 Lung operations
• CPC Class Codes: A61B 2017/1205 Introduction devices
• CPC Class Codes: A61B 2017/12054 Details concerning the detachment of the occluding device from the introduction device
• CPC Class Codes: A61F 2/04 Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts A61F2/18, A61F2/20 take precedence; devices, other than stent-grafts, providing patency to, or preventing collapsing of, tubular structures of the body other than stent-grafts, e.g. stents A61F2/82; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95
• CPC Class Codes: A61F 2002/043 Bronchi
• CPC Class Codes: A61M 16/04 Tracheal tubes catheters in general A61M25/00
• CPC Class Codes: A61M 16/0406 implanted flow modifiers
• CPC Class Codes: A61M 16/208 Non-controlled one-way valves, e.g. exhalation, check, pop-off non-rebreathing valves
• CPC Class Codes: A61M 2205/0266 Shape memory materials

Abstract

The invention provides improved medical devices, therapeutic treatment systems, and treatment methods for treatment of the lung. A lung volume reduction system includes an implantable device having an elongate body that is sized and shaped for delivery via the airway system to a lung airway of a patient. The implant is inserted and positioned while the implant is in a delivery configuration, and is reconfigured to a deployed configuration so as to locally compress adjacent tissue of the lung, with portions of the elongate body generally moving laterally within the airway so as to laterally compress lung tissue. A plurality of such implants will often be used to treat a lung of a patient.

Claims

1. A method for treating a lung of a patient, the lung including an airway system having a first elongate airway region with an associated first inner luminal surface and local airway central axis and a second elongate airway region with an associated second inner luminal surface and local airway central axis, the method comprising:

delivering an implant axially into the airway system so that a proximal portion of the implant is disposed within the first airway region and so that a distal portion of the implant is disposed within the second airway region;

tensioning a portion of the lung by deploying the implant in the airway system such that the deployed implant moves the second local airway axis of the second airway region laterally toward the first airway region by laterally urging the distal portion of the implant against the first inner luminal surface toward the proximal portion.

2. The method of claim 1, wherein the deployed implant comprises a bent configuration that bends the airway system.

3. The method of claim 1, wherein the implant comprises a tubular member, the tubular member including one or more notches and a pull-wire within a lumen of the tubular member and wherein the implant is deployed by actuating the pull-wire to activate the implant from a first configuration to a second configuration.

4. The method of claim 1, wherein the implant comprises a resilient material configured to naturally return the implant to a desired configuration, and wherein the implant is configured to be strained to a first configuration during delivery of the implant into the airway system and deployed to a second configuration to urge the first airway region laterally toward the second airway region.

5. The method of claim 1, wherein the proximal portion and the distal portion of the implant comprise hooks, the hooks configured to anchor the proximal portion and the distal portion of the implant to the first and second airway regions, respectively.

6. The method of claim 1, further comprising deploying a one-way valve proximal to a diseased portion of the airway system, the deployed one-way valve configured to allow air and mucous to pass through the valve out of the diseased portion of the airway system.

7. The method of claim 1, further comprising deploying an occlusion device proximal to a diseased portion of the airway system, the occlusion device configured to prevent air from entering and exiting the diseased portion.

8. The method of claim 1, further comprising scarring a portion of the lung.

9. The method of claim 1, wherein the proximal end of the implant is not driven into the lung tissue upon deployment of the implant so as to facilitate recapture of implant in the event that the implant is deployed in a less than ideal position or orientation.

10. The method of claim 1, wherein the implant further comprises a covering disposed over at least a portion of the implant.

11. The method of claim 1, further comprising delivering therapeutic agent to a portion of the lung.

12. A kit for treating a lung of a patient, the lung including an airway system having first airway region with an associated first inner luminal surface and a second airway region with an associated second inner luminal surface, the kit comprising:

an implant having a proximal portion and a distal portion and an elongate body therebetween, the implant configured to be delivered through the airway system to a portion of the lung in a delivery configuration and deployed to a deployed configuration; and

wherein the deploying of the implant from the delivery configuration to the deployed configuration within the airway tensions a portion of the lung by moving the first airway region laterally toward the second airway region by having the proximal and distal portions of the implant laterally urge against the first and second inner luminal surfaces, respectively; and

a cartridge for containing the implant.

13. The kit of claim 12, wherein the implant is configured to urge the first airway region laterally toward the second airway region by bending the airway system.

14. The kit of claim 12, wherein the implant comprises a tubular member, the tubular member including one or more notches and a pull-wire within a lumen of the tubular member and wherein the implant is deployed by a user actuation of the pull-wire to activate the implant from the delivery configuration to the deployed configuration.

15. The kit of claim 12, wherein the implant comprises a resilient material configured to naturally return the implant from the delivery configuration to the deployed configuration.

16. The kit of claim 12, wherein the proximal portion and the distal portion of the implant comprise hooks, the hooks configured to anchor the proximal portion and the distal portion of the implant to the first and second airway regions, respectively.

17. The kit of claim 12, further comprising a one-way valve to configured to be deployed proximal to a diseased portion of the airway system, the deployed one-way valve configured to allow air and mucous to pass through the valve out of the diseased portion of the airway system.

18. The kit of claim 12, further comprising an occlusion device configured to be deployed proximal to a diseased portion of the airway system, the occlusion device configured to prevent air from entering and exiting the diseased portion.

19. The kit of claim 12, further comprising a scarring device, the scarring device configured to cause scarring at specific portions of the lung.

20. The kit of claim 12, wherein the proximal portion of the implant is configured to not be driven into the lung tissue upon deployment of the implant so as to facilitate recapture of implant in the event that the implant is deployed in a less than ideal position or orientation.

21. The kit of claim 12, wherein the implant further comprises a covering disposed over at least a portion of the implant.

22. A method for treating a lung of a patient, the lung including a first airway region with an associated first inner luminal surface and a second airway region with an associated second inner luminal surface, the method comprising:

delivering an implant axially into the lung so that a first portion of the implant is disposed within the first airway region and so that a second portion of the implant is disposed within the second airway region;

deploying the implant by laterally urging the first portion of the implant against the first inner luminal surface toward the second portion and by laterally urging the second portion of the implant against the second inner luminal surface toward the first portion, thereby laterally urging the first airway region toward the second airway region and thereby tensioning a portion of the lung.