Tissue-derived mesh for orthopedic regeneration

• US 8,740,987 B2
• Filed: 12/20/2004
• Issued: 06/03/2014
• Est. Priority Date: 06/04/2001
• Status: Active Grant

• Current Assignee: Warsaw Orthopedic Incorporated (Medtronic Plc)
• Original Assignee: Warsaw Orthopedic Incorporated (Medtronic Plc)
• Inventors: Geremakis, Perry, Grasso, Jennifer, Knaack, David, Lin, Jo-Wen, Shimp, Lawrence, Waterman, Robert, Winterbottom, John
• Primary Examiner(s): PREBILIC, PAUL B
• Application Number:
  US11/018,853
• Publication Number:
  US 20050283255A1
• Time in Patent Office: 3,452 Days
• Field of Search: 623/23.51, 623/23.63, 623/13.17, 623/13.18, 623/13.19, 623/23.57, 623/16.11, 606/76, 606/151
• US Class Current: 623/23.51
• CPC Class Codes: A61B 17/06166 Sutures suture materials A61L17/00; manufacture of artificial threads D01D; treatment of threads D06M
• CPC Class Codes: A61B 2017/00004 (bio)absorbable, (bio)resorbable, resorptive for implantable prostheses A61F2210/0004
• CPC Class Codes: A61F 2/0063 Implantable repair or support meshes, e.g. hernia meshes
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/3094 Designing or manufacturing processes
• CPC Class Codes: A61F 2/4455 for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages intervertebral discs A61F2/442
• CPC Class Codes: A61F 2/4601 for introducing bone substitute, for implanting bone graft implants or for compacting them in the bone cavity
• CPC Class Codes: A61F 2/4644 Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material bone material A61F2/28; disintegrating or milling devices B02C
• CPC Class Codes: A61F 2002/30062 (bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
• CPC Class Codes: A61F 2002/30677 Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2240/001 Designing or manufacturing processes
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61F 2310/00011 Metals or alloys
• CPC Class Codes: A61F 2310/00179 Ceramics or ceramic-like structures
• CPC Class Codes: A61F 2310/00359 Bone or bony tissue
• CPC Class Codes: A61L 27/3608 Bone, e.g. demineralised bone matrix [DBM], bone powder
• CPC Class Codes: A61L 27/3633 Extracellular matrix [ECM]
• CPC Class Codes: A61L 27/3641 characterised by the site of application in the body materials for artificial blood vessels A61L27/507; materials for use in artificial skin A61L27/60
• CPC Class Codes: A61L 27/3645 Connective tissue
• CPC Class Codes: A61L 27/3804 : characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
• CPC Class Codes: A61L 27/3843 : Connective tissue
• CPC Class Codes: B29C 67/02 : Moulding by agglomerating B29C67/20 takes precedence

Abstract

An implant including a substantially cohesive aggregate comprising bone-derived particles. Cohesiveness is maintained by a member of mechanical interlocking, engagement of adjacent bone-derived particles with one another through engagement with a binding agent, thermal bonding, chemical bonding, or a matrix material in which the bone-derived particles are retained. The aggregate is shaped as a one-dimensional or two-dimensional body.

Claims

1. An implant comprising a flexible porous gauze woven from a plurality of cohesive aggregate strands, each of the cohesive aggregate strands comprising bone particles and a gene activated matrix, and the bone particles of each strand are retained in a polymer matrix, the polymer matrix having a particle width from about 0.05 mm to about 150 mm.

2. The implant of claim 1, wherein the polymer matrix is or comprises polyurethane.

3. The implant of claim 1, wherein the gauze is woven from the plurality of cohesive aggregate strands in the form of a braid.

4. The implant of claim 1, wherein the polymer matrix is or comprises a polylactide, poly(L-lactide-co-DL-lactide), or tyrosine-based polycarbonate.

5. The implant of claim 1, wherein the porous gauze retains an agent;

the agent being selected from the group consisting of trophic factors, adhesives, plasticizers, therapeutic agents, biostatic agents, biocidal agents, bioactive agents, biomolecules, small molecules, and any combinations of the above.

6. The implant of claim 1, wherein the implant further comprises a substrate on which the gauze is coated.

7. The implant of claim 6, wherein the substrate has a shape selected from the group consisting of a member of a bone, sponge, cone, portion of cone, tube, particle, rod, sphere, strand, coiled strand, capillary network, film, fiber, mesh, sheet, threaded cylinder, rod, hinge, rivet, anchor, spheroid, ellipsoid, oblate spheroid, prolate ellipsoid, hyperbolic paraboloid and bulk implant.

8. The implant of claim 1, further comprising cells selected from the group consisting of connective tissue cells, organ cells, muscle cells, nerve cells, and stem cells.

9. The implant of claim 8, wherein the cells are selected from the group consisting of osteoblasts, osteoclasts, tenocytes, fibroblasts, chondrocytes, ligament cells, and mesenchymal stem cells.

10. The implant of claim 1, further comprising a permanent implant about at least a portion of which the gauze is wrapped.

11. The implant of claim 1, wherein the implant is a composite comprising the gauze and a second material, wherein the second material is selected from the group consisting of a hydrogel, a ceramic, a metal, a natural polymer, a synthetic, recombinant, or modified version of a natural polymer, and a synthetic polymer.