Penetrating pharmaceutical foam

• US 8,741,265 B2
• Filed: 03/04/2013
• Issued: 06/03/2014
• Est. Priority Date: 10/25/2002
• Status: Active Grant

• Current Assignee: VYNE Therapeutics, Inc.
• Original Assignee: Foamix Ltd. (VYNE Therapeutics, Inc.)
• Inventors: Tamarkin, Dov, Friedman, Doron, Eini, Meir
• Primary Examiner(s): FISHER, ABIGAIL L
• Application Number:
  US13/784,085
• Publication Number:
  US 20130183251A1
• Time in Patent Office: 456 Days
• Field of Search: 424/47, 424/43, 424/401, 514/945, 514/588, 514/557
• US Class Current: 424/47
• CPC Class Codes: A01N 25/16 Foams
• CPC Class Codes: A01N 53/00 Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
• CPC Class Codes: A61K 2800/75 Anti-irritant
• CPC Class Codes: A61K 31/167 having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• CPC Class Codes: A61K 31/17 having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine isoureas, isothioureas A61K31/155; sulfonylureas A61K31/64
• CPC Class Codes: A61K 31/19 Carboxylic acids, e.g. valproic acid salicylic acid A61K31/60
• CPC Class Codes: A61K 31/196 the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
• CPC Class Codes: A61K 31/496 Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• CPC Class Codes: A61K 31/497 containing further heterocyclic rings
• CPC Class Codes: A61K 45/00 Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 47/12 Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 47/14 Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• CPC Class Codes: A61K 47/18 Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
• CPC Class Codes: A61K 47/22 Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
• CPC Class Codes: A61K 47/24 containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• CPC Class Codes: A61K 47/36 Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• CPC Class Codes: A61K 47/38 Cellulose; Derivatives thereof
• CPC Class Codes: A61K 47/44 Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin synthetic glycerides, e.g. medium-chain triglycerides, A61K47/14
• CPC Class Codes: A61K 8/046 : Aerosols; Foams
• CPC Class Codes: A61K 8/06 : Emulsions
• CPC Class Codes: A61K 8/062 : Oil-in-water emulsions
• CPC Class Codes: A61K 8/31 : Hydrocarbons
• CPC Class Codes: A61K 8/365 : Hydroxycarboxylic acids; Ketocarboxylic acids
• CPC Class Codes: A61K 8/42 : Amides
• CPC Class Codes: A61K 9/0014 : Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/107 : Emulsions ; Emulsion preconcentrates; Micelles composition of emulsions A61K47/00
• CPC Class Codes: A61K 9/12 : Aerosols; Foams A61K9/0043, A61K9/0056, A61K9/006, A61K9/0073 take precedence; spray-films A61K9/7015
• CPC Class Codes: A61K 9/122 : Foams; Dry foams edible foams A61K9/0056
• CPC Class Codes: A61K 9/124 : characterised by the propellant
• CPC Class Codes: A61P 15/00 : Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives
• CPC Class Codes: A61P 15/02 : for disorders of the vagina
• CPC Class Codes: A61P 17/00 : Drugs for dermatological disorders
• CPC Class Codes: A61P 17/10 : Anti-acne agents
• CPC Class Codes: A61P 17/18 : Antioxidants, e.g. antiradicals preparations for protection against sunlight A61Q17/00
• CPC Class Codes: A61P 29/00 : Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/04 : Antibacterial agents
• CPC Class Codes: A61P 31/10 : Antimycotics
• CPC Class Codes: A61P 31/12 : Antivirals
• CPC Class Codes: A61P 35/00 : Antineoplastic agents
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61Q 17/02 : containing insect repellants
• CPC Class Codes: A61Q 19/00 : Preparations for care of the skin
• CPC Class Codes: A61Q 19/08 : Anti-ageing preparations
• CPC Class Codes: A61Q 19/10 : Washing or bathing preparations

Abstract

The invention relates to an alcohol-free cosmetic or pharmaceutical foam composition comprising water, a hydrophobic solvent, a surface-active agent, a gelling agent, an active component selected from the group of urea, hydroxy acid and a therapeutic enhancer and a propellant. The foam further comprises active agents and excipients with therapeutic properties having enhanced skin penetration.

Claims

1. A foamable composition comprising a carrier and a liquefied or a compressed gas propellant, the carrier comprising:

i) about 0.1% to about 5% by weight of the carrier of a surface-active agent;

ii) about 2% to about 75% by weight of the carrier of a liquid, non-volatile hydrophobic solvent;

iii) about 0.01% to about 5% by weight of the carrier of a gelling agent; and

iv) water,

wherein the surface active agent is selected from the group consisting of polysorbate, a polyoxyethylene fatty acid ester, a polyoxyethylene alkyl ether, a sucrose ester, a partial ester of sorbitol, a partial ester of sorbitol anhydride, sodium methyl cocoyl taurate, sodium methyl oleoyl taurate, sodium lauryl sulfate, triethanolamine lauryl sulfate, a betaine, a mono-, di- or tri-ester of sucrose with food fatty acids (sucrose esters), a monoglyceride, a diglyceride, polyoxyethylene (20) sorbitan monostearate, polyoxyethylene (20) sorbitan monooleate, Myrj 45 (Polyoxyethylene (8) Stearate), Myrj 49 (polyoxyethylene (20) stearate), Myrj 59 (polyoxyethylene (100) stearate), a polyoxyethylene cetyl ether, a polyoxyethylene palmityl ether, a polyethylene oxide hexadecyl ether, Brij 52 (polyoxyethylene (2) cetyl ether), Brij 56 (polyoxyethylene (10) cetyl ether), sorbitan monolaurate, isoceteth-20, cocamidopropyl betaine, and Myrj 52 (polyoxyethylene 40 stearate);

wherein a breakable foam forms upon dispensing the foamable composition.

2. The foamable composition of claim 1, wherein the carrier further comprises a therapeutically effective amount of at least one active agent.

3. The foamable composition of claim 1, wherein the liquefied or compressed gas propellant is at a concentration of about 3% to about 18% by weight of the carrier.

4. The foamable composition of claim 1, wherein the carrier is an oil in water emulsion.

5. The foamable composition of claim 1, wherein the carrier further comprises about 1% to about 30% by weight of the carrier of a therapeutic enhancer.

6. The foamable composition of claim 5, wherein the therapeutic enhancer is selected from the group consisting of a polyhydric alcohol, propylene glycol, butylene glycol, glycerol, pentaerythritol, sorbitol, mannitol, an oligosaccharide, dimethyl isosorbide, monooleate of ethoxylated glycerides (with 8 to 10 ethylene oxide units), a polyethylene glycol 200-600, transcutol (diethylene glycol monoethyl ether), glycofurol (tetrahydrofurfuryl alcohol PEG ether), a cyclodextrin, and mixtures of any two or more thereof.

7. The foamable composition of claim 1, wherein the breakable foam has a specific gravity of between about 0.01 g/mL and about 0.1 g/mL.

8. The foamable composition of claim 1, wherein the carrier further comprises a foam adjuvant.

9. The foamable composition of claim 1, wherein the hydrophobic solvent is selected from the group consisting of vegetable oil, marine oil, mineral oil, an emollient, silicone oil, a plant-derived therapeutic oil, and mixtures of any two or more thereof.

10. The foamable composition of claim 2, wherein the active agent is selected from the group consisting of an antibacterial agent, an anti-fungal agent, an anti-viral agent, an anti-inflammatory agent, a steroid, a corticosteroid, anti-histamine, a nonsteroidal anti-inflammatory agent, an immunomodulating agent, an immunosuppressant, an anti-allergic agent, a local anesthetic agent, a keratolytically active agent, a retinoid, an insecticide, an insect repellent, an anti-cancer drug, a photodynamic therapy agent, an active agent for burns, wounds, cuts and ulcers, an anti-acne active agent, an anti-wrinkle active agent, an anti-atrophy active agent, an anti-oxidant, a radical scavenger, a self-tanning active agent, a skin lightening or whitening agent, an agent suitable for the treatment of a hair growth disorder, a humectant, a moisture-retaining agent, a hydroxy acid, an agent for treating cellulite, and mixtures of any two or more thereof.

11. The foamable composition of claim 1, wherein the ratio between the surface active agent and the hydrophobic solvent is between about 1:

8 and about 1;

16.

12. The foamable composition of claim 1, wherein the ratio between the surface active agent and the hydrophobic solvent is between about 1:

16 and about 1;

32.

13. The foamable composition of claim 1, wherein the carrier contains no more than 7.5% by weight of the carrier of methyl alcohol, ethyl alcohol, isopropyl alcohol, butyl alcohol, or mixtures thereof.

14. A foamable composition comprising a carrier and a liquefied or a compressed gas propellant, the carrier comprising:

i) about 0.1% to about 5% by weight of the carrier of a surface-active agent;

ii) 0.01% to about 5% by weight of the carrier of a gelling agent;

iii) a therapeutic enhancer selected from the group consisting of a polyhydric alcohol, propylene glycol, butylene glycol, glycerol, pentaerythritol, sorbitol, mannitol, an oligosaccharide, dimethyl isosorbide, monooleate of ethoxylated glycerides (with 8 to 10 ethylene oxide units), a polyethylene glycol 200-600, transcutol (diethylene glycol monoethyl ether), glycofurol (tetrahydrofurfuryl alcohol PEG ether), a cyclodextrin, and mixtures of any two or more thereof; and

iv) water,

wherein a breakable foam forms upon dispensing the foamable composition.

15. The foamable composition of claim 14, wherein the liquefied or compressed gas propellant is at a concentration of about 3% to about 18% by weight of the carrier.

16. The foamable composition of claim 14, wherein the carrier further comprises a therapeutically effective amount of at least one active agent.

17. The foamable composition of claim 14, wherein the active agent is selected from the group consisting of an antibacterial agent, an anti-fungal agent, an anti-viral agent, an anti-inflammatory agent, a steroid, a corticosteroid, anti-histamine, a nonsteroidal anti-inflammatory agent, an immunomodulating agent, an immunosuppressant, an anti-allergic agent, a local anesthetic agent, a keratolytically active agent, a retinoid, an insecticide, an insect repellent, an anti-cancer drug, a photodynamic therapy agent, an active agent for burns, wounds, cuts and ulcers, an anti-acne active agent, an anti-wrinkle active agent, an anti-atrophy active agent, an anti-oxidant, a radical scavenger, a self-tanning active agent, a skin lightening or whitening agent, an agent suitable for the treatment of a hair growth disorder, a humectant, a moisture-retaining agent, a hydroxy acid, an agent for treating cellulite, and mixtures of any two or more thereof.

18. A foamable composition comprising a carrier and a liquefied or a compressed gas propellant, the carrier comprising:

i) about 0.1% to about 5% by weight of the carrier of a surface-active agent;

ii) about 2% to about 75% by weight of the carrier of a liquid, non-volatile hydrophobic solvent;

iii) about 0.01% to about 5% by weight of the carrier of a gelling agent;

iv) a foam adjuvant; and

iv) water,

wherein a breakable foam forms upon dispensing the foamable composition.

19. The foamable composition of claim 18, wherein the surface-active agent is selected from the group consisting of a non ionic surface-active agent, a cationic surface-active agent, an amphoteric surface-active agent, a zwitterionic-surface active agent, and mixtures of any two or more thereof.

21. The foamable composition of claim 18, wherein the surface-active agent is a non-ionic surfactant.

22. The foamble composition of claim 18, wherein the carrier further comprises a therapeutically effective amount of at least one active agent.

23. The foamble composition of claim 22, wherein the active agent is selected from the group consisting of an antibacterial agent, an anti-fungal agent, an anti-viral agent, an anti-inflammatory agent, a steroid, a corticosteroid, anti-histamine, a nonsteroidal anti-inflammatory agent, an immunomodulating agent, an immunosuppressant, an anti-allergic agent, a local anesthetic agent, a keratolytically active agent, a retinoid, an insecticide, an insect repellent, an anti-cancer drug, a photodynamic therapy agent, an active agent for burns, wounds, cuts and ulcers, an anti-acne active agent, an anti-wrinkle active agent, an anti-atrophy active agent, an anti-oxidant, a radical scavenger, a self-tanning active agent, a skin lightening or whitening agent, an agent suitable for the treatment of a hair growth disorder, a humectant, a moisture-retaining agent, a hydroxy acid, an agent for treating cellulite, and mixtures of any two or more thereof.

20. A foamable composition comprising a carrier and a liquefied or a compressed gas propellant, the carrier comprising:

i) about 0.1% to about 5% by weight of the carrier of a surface-active agent;

ii) about 2% to about 75% by weight of the carrier of a liquid, non-volatile hydrophobic solvent;

iii) about 0.01% to about 5% by weight of the carrier of a gelling agent; and

iv) water,

wherein the ratio of surface active agent to hydrophobic solvent is about 1;

8 to about 1;

16; and

wherein a breakable foam forms upon dispensing the foamable composition.

24. The foamable composition of claim 20, wherein the surface-active agent is a mixture of a non ionic surface-active agent and an ionic surface-active agent in a 1:

1 to 20;

1 ratio.

25. The foamble composition of claim 20, wherein the hydrophobic solvent is about 20% to about 50% by weight of the carrier.

26. The foamble composition of claim 20, wherein the hydrophobic solvent is 10% to about 20% by weight of the carrier.

27. The foamble composition of claim 20, wherein the carrier further comprises a therapeutically effective amount of at least one active agent.

28. The foamble composition of claim 27, wherein the active agent is selected from the group consisting of an antibacterial agent, an anti-fungal agent, an anti-viral agent, an anti-inflammatory agent, a steroid, a corticosteroid, anti-histamine, a nonsteroidal anti-inflammatory agent, an immunomodulating agent, an immunosuppressant, an anti-allergic agent, a local anesthetic agent, a keratolytically active agent, a retinoid, an insecticide, an insect repellent, an anti-cancer drug, a photodynamic therapy agent, an active agent for burns, wounds, cuts and ulcers, an anti-acne active agent, an anti-wrinkle active agent, an anti-atrophy active agent, an anti-oxidant, a radical scavenger, a self-tanning active agent, a skin lightening or whitening agent, an agent suitable for the treatment of a hair growth disorder, a humectant, a moisture-retaining agent, a hydroxy acid, an agent for treating cellulite, and mixtures of any two or more thereof.