Highly porous, recognitive polymer systems

• US 8,741,316 B2
• Filed: 12/04/2008
• Issued: 06/03/2014
• Est. Priority Date: 03/12/2007
• Status: Active Grant

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Peppas, Nicholas A., Durgam, Aditya
• Primary Examiner(s): Claytor, Renee
• Assistant Examiner(s): Kantamneni, Shobha
• Application Number:
  US12/328,626
• Publication Number:
  US 20090081265A1
• Time in Patent Office: 2,007 Days
• Field of Search: 424/400, 424/464, 424/486, 526/72, 514/400, 514/464, 514/486
• US Class Current: 424/400
• CPC Class Codes: A61K 31/137 Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
• CPC Class Codes: A61K 47/32 Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers , poly(meth)acrylates, or polyvinyl pyrrolidone
• CPC Class Codes: A61K 9/7007 Drug-containing films, membranes or sheets A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence
• CPC Class Codes: C08J 2201/044 Elimination of an inorganic solid phase
• CPC Class Codes: C08J 2201/0444 Salts
• CPC Class Codes: C08J 2201/0446 Elimination of NaCl only
• CPC Class Codes: C08J 9/26 by elimination of a solid phase from a macromolecular composition or article, e.g. leaching out

Abstract

The present invention includes compositions, methods, systems of making a composition that includes one or more active agent; a recognitive polymeric matrix; and a porosigen, wherein the composition comprises a porous recognitive, swellable hydrogel that dissociates under conditions of low water or humidity.

Claims

1. A composition comprising:

one or more active agents disposed in a recognitive polymeric matrix comprising

a methacrylic acid polymerized to form a polymeric hydrogel matrix;

a porosigen distributed in the polymeric hydrogel matrix wherein the porosigen comprises sodium chloride in a final weight percent of between 20 and 90 percent of the composition;

a recognitive molecule disposed in the polymeric hydrogel matrix and associated with the one or more active agents to form a porous recognitive polymeric hydrogel,

wherein the recognitive molecule recognizes a recognized agent and the porous recognitive polymeric hydrogel dissociates in the presence of the recognized agent to release the one or more active agents, wherein the recognitive agent comprises D-glucose and the one or more active agents comprising insulin.

2. The composition of claim 1, wherein the porous recognitive polymeric hydrogel is swellable and swells, cracks, dissolves, dissociates or melts under conditions of low water or humidity.

3. The composition of claim 1, wherein the porosigen has a mole percent of between 30 and 90 mole percent of the composition during the polymerization of the polymer.

4. The composition of claim 1, wherein a loss of structural integrity of the porous recognitive polymeric hydrogel is due to:

osmosis upon the presence and binding of the molecule leading to rupture due to swelling;

change of the solubility of the polymeric network leading to polymer dissolution;

local temperature changes leading to expansion melting or both of the polymeric network or combinations thereof.

5. The composition of claim 1, wherein the recognitive polymeric matrix is formed into one or more layers.

6. The composition of claim 1, wherein the recognitive polymeric matrix is formed into one or more layers, each of which recognizes a different recognized agent and each of which provides a barrier to the release of one or more different active or inert agents or both.

7. The composition of claim 1, wherein the recognitive polymeric matrix is formed into a sphere, film, planar, semi-spherical, cylinder, rod, hemispheres, conical, hemi-cylinders or combinations thereof.