Highly porous, recognitive polymer systems
First Claim
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1. A composition comprising:
- one or more active agents disposed in a recognitive polymeric matrix comprisinga methacrylic acid polymerized to form a polymeric hydrogel matrix;
a porosigen distributed in the polymeric hydrogel matrix wherein the porosigen comprises sodium chloride in a final weight percent of between 20 and 90 percent of the composition;
a recognitive molecule disposed in the polymeric hydrogel matrix and associated with the one or more active agents to form a porous recognitive polymeric hydrogel,wherein the recognitive molecule recognizes a recognized agent and the porous recognitive polymeric hydrogel dissociates in the presence of the recognized agent to release the one or more active agents, wherein the recognitive agent comprises D-glucose and the one or more active agents comprising insulin.
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Abstract
The present invention includes compositions, methods, systems of making a composition that includes one or more active agent; a recognitive polymeric matrix; and a porosigen, wherein the composition comprises a porous recognitive, swellable hydrogel that dissociates under conditions of low water or humidity.
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7 Claims
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1. A composition comprising:
one or more active agents disposed in a recognitive polymeric matrix comprising a methacrylic acid polymerized to form a polymeric hydrogel matrix; a porosigen distributed in the polymeric hydrogel matrix wherein the porosigen comprises sodium chloride in a final weight percent of between 20 and 90 percent of the composition; a recognitive molecule disposed in the polymeric hydrogel matrix and associated with the one or more active agents to form a porous recognitive polymeric hydrogel, wherein the recognitive molecule recognizes a recognized agent and the porous recognitive polymeric hydrogel dissociates in the presence of the recognized agent to release the one or more active agents, wherein the recognitive agent comprises D-glucose and the one or more active agents comprising insulin. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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