Hydrogel compositions with an erodible backing member

• US 8,741,331 B2
• Filed: 06/12/2013
• Issued: 06/03/2014
• Est. Priority Date: 05/01/2001
• Status: Expired due to Term

• Current Assignee: AV Topchiev Institute of Petrochemical Synthesis, Corium LLC
• Original Assignee: A V Topchiev Institute of Petrochemicals Synthesis Russian Academy of Sciences, Corium International, Inc.
• Inventors: Singh, Parminder, Faasse, Adrian, Cleary, Gary W., Mudumba, Sri, Feldstein, Mikhail M., Bairamov, Danir F.
• Primary Examiner(s): GHALI, ISIS A D
• Application Number:
  US13/916,526
• Publication Number:
  US 20130273127A1
• Time in Patent Office: 356 Days
• Field of Search: None
• US Class Current: 424/434
• CPC Class Codes: A61C 19/066 Bleaching devices; Whitening agent applicators for teeth, e.g. trays or strips
• CPC Class Codes: A61K 2800/262 Transparent; Translucent
• CPC Class Codes: A61K 2800/54 Polymers characterized by specific structures/properties
• CPC Class Codes: A61K 2800/5422 nonionic
• CPC Class Codes: A61K 8/0204 Specific forms not provided for by any of groups A61K8/0208 - A61K8/14
• CPC Class Codes: A61K 8/0208 Tissues; Wipes; Patches
• CPC Class Codes: A61K 8/042 Gels
• CPC Class Codes: A61K 8/22 Peroxides; Oxygen; Ozone
• CPC Class Codes: A61K 8/42 Amides
• CPC Class Codes: A61K 8/731 Cellulose; Quaternized cellulose derivatives
• CPC Class Codes: A61K 8/733 Alginic acid; Salts thereof
• CPC Class Codes: A61K 8/8147 Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
• CPC Class Codes: A61K 8/8152 Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
• CPC Class Codes: A61K 8/817 Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
• CPC Class Codes: A61K 8/8176 Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
• CPC Class Codes: A61K 8/86 Polyethers
• CPC Class Codes: A61L 15/60 Liquid-swellable gel-forming materials, e.g. super-absorbents
• CPC Class Codes: A61L 15/64 specially adapted to be resorbable inside the body
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• CPC Class Codes: C08L 2312/00 Crosslinking

Abstract

A composition is provided, wherein the composition comprises a water-swellable, water-insoluble polymer, a blend of a hydrophilic polymer with a complementary oligomer capable of hydrogen or electrostatic bonding to the hydrophilic polymer. The composition also includes a backing member. Active ingredients, such as a whitening agent, may be included. The composition finds utility as an oral dressing, for example, a tooth whitening composition that is applied to the teeth in need of whitening. The composition can be designed to be removed when the degree of whitening has been achieved or left in place and allowed to erode entirely. In certain embodiments, the composition is translucent. Methods for preparing and using the compositions are also disclosed.

Claims

1. A composition, comprising:

(a) a hydrogel comprising;

(i) a water-swellable, water-insoluble acrylate polymer which is a copolymer of methacrylic acid and methyl methacrylate and is insoluble in aqueous fluid having a pH of 5.5 or below;

(ii) a blend of a hydrophilic polymer with a complementary oligomer capable of hydrogen or electrostatic bonding to the hydrophilic polymer; and

(iii) an active agent; and

(b) a backing member comprising a material selected from acrylate polymers, starches, alginic acid, alginates, polyamino acids, and combinations thereof, wherein said backing member erodes in a moist environment at a slower rate than the hydrogel.

2. A composition, comprising:

(a) a hydrogel comprising;

(i) a water-swellable, water-insoluble cellulose ester polymer which renders the hydrogel tacky prior to application to a moist surface, but nontacky upon absorption of water;

(ii) a blend of a hydrophilic polymer with a complementary oligomer capable of hydrogen or electrostatic bonding to the hydrophilic polymer; and

(iii) an active agent; and

(b) a backing member that erodes in a moist environment at a slower rate than the hydrogel.

3. A composition, comprising:

(a) a hydrogel comprising;

(i) a water-swellable alginic acid polymer which is insoluble in aqueous fluid having a pH of 5.5 or below;

(ii) a blend of a hydrophilic polymer with a complementary oligomer capable of hydrogen or electrostatic bonding to the hydrophilic polymer; and

(iii) an active agent; and

(b) a backing member that erodes in a moist environment at a slower rate than the hydrogel.

4. A method for whitening teeth while minimizing tooth sensitivity, wherein said method comprises applying to teeth a composition comprising:

(a) a hydrogel comprising;

(i) a water-swellable, water-insoluble acrylate polymer which is a copolymer of methacrylic acid and methyl methacrylate and is insoluble in aqueous fluid having a pH of 5.5 or below;

(ii) a blend of a hydrophilic polymer with a complementary oligomer capable of hydrogen or electrostatic bonding to the hydrophilic polymer; and

(iii) an active agent; and

(b) a backing member comprising a material selected from acrylate polymers, starches, alginic acid, alginates, polyamino acids, and combinations thereof, wherein said backing member erodes in a moist environment at a slower rate than the hydrogel.

5. A method for whitening teeth while minimizing tooth sensitivity, wherein said method comprises applying to teeth a composition comprising:

(a) a hydrogel comprising;

(i) a water-swellable, water-insoluble cellulose ester polymer which renders the hydrogel tacky prior to application to a moist surface, but nontacky upon absorption of water;

(ii) a blend of a hydrophilic polymer with a complementary oligomer capable of hydrogen or electrostatic bonding to the hydrophilic polymer; and

(iii) an active agent; and

(b) a backing member that erodes in a moist environment at a slower rate than the hydrogel.

6. A method for whitening teeth while minimizing tooth sensitivity, wherein said method comprises applying to teeth a composition comprising:

(a) a hydrogel comprising;

(i) a water-swellable alginic acid polymer which is insoluble in aqueous fluid having a pH of 5.5 or below;

(ii) a blend of a hydrophilic polymer with a complementary oligomer capable of hydrogen or electrostatic bonding to the hydrophilic polymer; and

(iii) an active agent; and

(b) a backing member that erodes in a moist environment at a slower rate than the hydrogel.