Monoclonal antibodies against ANGPTL3
First Claim
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1. A monoclonal antibody that binds to angiopoietin-like protein 3 (ANGPTL3) and neutralizes at least one activity of ANGPTL3, wherein the antibody binds to a peptide consisting of the amino acid sequence of SEQ ID NO:
- 9 with at least 3-fold greater affinity than the antibody binds to a peptide consisting of the amino acid sequence of SEQ ID NO;
86, 87, or 88.
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Accused Products
Abstract
Monoclonal antibodies that specifically bind to ANGPTL3 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL3 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.
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Citations
17 Claims
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1. A monoclonal antibody that binds to angiopoietin-like protein 3 (ANGPTL3) and neutralizes at least one activity of ANGPTL3, wherein the antibody binds to a peptide consisting of the amino acid sequence of SEQ ID NO:
- 9 with at least 3-fold greater affinity than the antibody binds to a peptide consisting of the amino acid sequence of SEQ ID NO;
86, 87, or 88. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
- 9 with at least 3-fold greater affinity than the antibody binds to a peptide consisting of the amino acid sequence of SEQ ID NO;
Specification