Simple sugar concentration sensor and method

• US 8,743,355 B2
• Filed: 07/24/2013
• Issued: 06/03/2014
• Est. Priority Date: 10/16/2012
• Status: Active Grant

• Current Assignee: K Sciences Gp, LLC
• Original Assignee: K Sciences Gp, LLC
• Inventors: Korman, Valentin
• Primary Examiner(s): Punnoose, Roy M
• Application Number:
  US13/950,054
• Publication Number:
  US 20140104596A1
• Time in Patent Office: 314 Days
• Field of Search: 356/39, 356/364
• US Class Current: 356/39
• CPC Class Codes: A61B 2560/0443 Modular apparatus
• CPC Class Codes: A61B 2562/0238 Optical sensor arrangements for performing transmission measurements on body tissue
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14558 by polarisation
• CPC Class Codes: A61B 5/6815 Ear
• CPC Class Codes: A61B 5/7225 Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation A61B5/30, A61B5/316 take precedence; transformers for specific applications H01F38/00; amplifiers H03F
• CPC Class Codes: G01N 21/21 Polarisation-affecting properties G01N21/19 takes precedence
• CPC Class Codes: G01N 2201/062 LED's
• CPC Class Codes: G01N 2201/0683 Brewster plate; polarisation controlling elements

Abstract

A glucose sensor comprising an optical energy source having an emitter with an emission pattern; a first polarizer intersecting the emission pattern; a second polarizer spaced a distance from the first polarizer and intersecting the emission pattern, the second polarizer rotated relative to the first polarizer by a first rotational amount Θ; a first optical detector intersecting the emission pattern; a second optical detector positioned proximal to the second polarizer, the first polarizer and the second polarizer being positioned between the optical energy source and the second optical detector, the second optical detector intersecting the emission pattern; a compensating circuit coupled to the second optical detector; and a subtractor circuit coupled to the compensating circuit and the first optical detector.

Claims

1. An apparatus for measuring change in sugar concentration in a fluid relative to a baseline concentration, the apparatus comprising:

a source of optical energy, said source having an emitter with an emission pattern;

a first optical detector spaced a distance from said source;

a second optical detector collocated with said first optical detector;

a plurality of polarizers optically between said source and said detectors, said plurality of polarizers comprising;

a first polarizer intersecting the emission pattern; and

a second polarizer rotated relative to the first polarizer by a first rotational amount Θ

, spaced a distance from the first polarizer, and proximal to said second optical detector, wherein said first polarizer is optically between said source and said second polarizer;

a volume of liquid, said volume intersecting said emission pattern and positioned optically between said first polarizer and said second polarizer and optically between said first polarizer and said first detector; and

at least one circuit coupled to said first optical detector and said second optical detector,

said at least one circuit comprising;

a compensating circuit coupled to said second optical detector;

a subtractor circuit coupled to said compensating circuit and said first optical detector; and

a gain circuit coupled to said subtractor circuit.

2. The apparatus of claim 1 wherein said at least one circuit further comprises:

a unity gain circuit coupled to and between said first optical detector and said subtractor circuit.

3. The apparatus of claim 1 wherein Θ

is 45.028 degrees.

4. The apparatus of claim 1 wherein the optical energy source is a near-infrared wavelength optical energy source.

5. The apparatus of claim 1 wherein the optical energy source is a red-wavelength energy source.

6. The apparatus of claim 1 wherein the optical energy source is a LED.

7. The apparatus of claim 1 wherein the optical energy source is a laser.

8. The apparatus of claim 1 wherein the fluid is blood.

9. The apparatus of claim 1 further comprising a form factor wearable around an ear, said form factor housing the optical energy source, the first polarizer, the second polarizer, the first optical detector, and the second optical detector.

10. The apparatus of claim 1 wherein Θ

is between thirty-five and fifty-five degrees (inclusive) of rotation from a baseline rotation caused by a baseline concentration of a simple sugar in a fluid for energy traveling a length L through said fluid.

11. The apparatus of claim 10 wherein Θ

is between forty and fifty degrees (inclusive).

12. The apparatus of claim 11 wherein Θ

is forty-five degrees.

13. The apparatus of claim 1 wherein said plurality of polarizers consists of said first polarizer and said second polarizer.

14. The apparatus of claim 1 wherein said optical energy is unmodulated.

15. A method of detecting an amount of change of sugar concentration in a subject fluid relative to a baseline concentration, the method comprising:

directing optical energy in a first direction;

positioning the subject fluid between a first polarizer and a first detector, between said first polarizer and a second polarizer rotated relative to the first polarizer by a first rotational amount Θ

, and between said first polarizer and a second detector, wherein said second polarizer is positioned between the first polarizer and said second detector;

passing the optical energy through the first polarizer to become once-polarized optical energy;

passing the once-polarized optical energy through the subject fluid to become rotated once-polarized optical energy;

detecting an intensity of the rotated once-polarized optical energy;

passing at least a portion of the rotated once-polarized optical energy through the second polarizer to become twice-polarized optical energy;

detecting the intensity of the twice-polarized optical energy;

providing a signal representative of a difference between the intensity of the rotated once-polarized optical energy and the intensity of the twice-polarized optical energy; and

correlating the signal to a sugar concentration.

16. The method of claim 15 wherein the optical energy is red-wavelength optical energy.

17. The method of claim 15 wherein the optical energy is near-infrared optical energy.

18. The method of claim 15 wherein said first optical detector is collocated with said second optical detector.

19. The method of claim 15 wherein the optical energy consists of one unmodulated light wave.