System having wireless implantable sensor

• US 8,744,544 B2
• Filed: 10/17/2008
• Issued: 06/03/2014
• Est. Priority Date: 10/17/2007
• Status: Active Grant

• Current Assignee: UIM Pressure Implant Incorporated
• Original Assignee: Integrated Sensing Systems Incorporated
• Inventors: Najafi, Nader, Sparks, Douglas Ray
• Primary Examiner(s): Hindenburg, Max
• Assistant Examiner(s): Foreman, Jonathan M
• Application Number:
  US12/253,540
• Publication Number:
  US 20090105557A1
• Time in Patent Office: 2,055 Days
• Field of Search: 600/309, 600/345, 600/504, 600/505, 600/506
• US Class Current: 600/345
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/0537 Measuring body composition by impedance, e.g. tissue hydration or fat content
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/6864 Burr holes
• CPC Class Codes: A61B 5/6882 Anchoring means

Abstract

A system for monitoring a charge-based physiological parameter within an internal organ of a living body, and a sensor adapted to be implanted in the living body and an organ therein. The sensor includes sensing elements adapted to sense the charge-based physiological parameter within the organ, and the sensing elements include at least first and second sensing elements that are electrically conductive, aligned, spaced apart and exposed at the exterior of the sensor. The sensor further includes a device for passing an alternating current from the first to the second sensing elements through an ionic solution contacting the sensing elements. The sensor also includes a device for generating a signal corresponding to the impedance of the ionic solution based on the alternating current.

Claims

1. A system for monitoring a charge-based physiological parameter of an ionic fluid within an internal organ of a living body, the system comprising at least one sensor adapted to be implanted in the living body and an organ therein, the sensor comprising:

a surface defining an exterior of the sensor relative to which the ionic fluid flows in a flow direction;

sensing elements adapted to sense the charge-based physiological parameter of the ionic fluid within the organ, the sensing elements comprising at least first and second sensing elements that are electrically conductive, aligned and spaced apart in the flow direction, and exposed at the exterior of the sensor so as to be contacted by the ionic fluid;

means for applying an alternating current in the flow direction, between the first and second sensing elements, and through the ionic fluid contacting the first and second sensing elements;

means for applying a biasing charge in a direction transverse to the flow direction to ionize the ionic fluid in a direction from the first and second sensing elements opposite the flow direction; and

means for generating a signal corresponding to the impedance of the ionic fluid based on the alternating current.

2. The system according to claim 1, wherein the charge-based physiological parameter sensed by the first and second sensing elements is chosen from the group consisting of flow rates, chemical concentrations, conductivity, and pH of the ionic fluid.

3. The system according to claim 1, wherein the ionic fluid is chosen from the group consisting of blood, cerebral spinal fluid, lymph, interstitial fluids, urine, saline solution, ringers lactate, intravenous solutions, drugs and dialysates.

4. The system according to claim 1, further comprising a readout device that is not adapted to be implanted in the living body, the readout device comprising means for establishing a wireless telemetry link with the sensor to obtain a reading of the charge-based physiological parameter.

5. The system according to claim 1, wherein the first and second sensing elements are pads that do not protrude from the surface.

6. The system according to claim 1, wherein the first and second sensing elements protrude from the surface.

7. The system according to claim 1, wherein the first and second sensing elements are disposed at a distal end of a wire that protrudes from the surface.

8. The system according to claim 1, wherein the means for applying the biasing charge to ionize the ionic fluid comprises a pair of biasing electrodes aligned and spaced apart in a direction transverse to the flow direction and transverse to the alignment of the first and second sensing elements.

9. The system according to claim 8, wherein the sensor further comprises a third sensing element aligned with the first and second sensing elements in the flow direction and spaced apart from the first and second sensing elements in the flow direction, and the pair of biasing electrodes are between the first and second sensing elements and the third sensing element.

10. The system according to claim 9, wherein the sensor further comprises means for applying an alternating current through the ionic fluid from the third sensing element to one of the first and second sensing elements in the flow direction.

11. The system according to claim 1, further comprising means for anchoring the sensor within a tubular-shaped passage.

12. The system according to claim 11, wherein the anchoring means comprises the first and second sensing elements, which protrude from the surface of the sensor.

13. The system according to claim 1, further comprising means for anchoring the sensor to a wall.

14. The system according to claim 1, wherein the sensor further comprises an additional sensing element adapted to sense an additional physiological parameter chosen from the group consisting of pressure, strain, temperature, and velocity.

15. The system according to claim 1, wherein the sensor further comprises an actuator.

16. A method of using the system of claim 1 to monitor the charge-based physiological parameter of the ionic fluid, the method comprising:

implanting the sensor within an internal organ of a living body so that the ionic fluid flows in the flow direction and the first and second sensing elements are aligned and spaced apart in the flow direction and contacted by the ionic fluid;

applying the alternating current from the first to the second sensing elements through the ionic fluid contacting the first and second sensing elements; and

generating the signal corresponding to the impedance of the ionic fluid based on the alternating current.

17. The method according to claim 16, further comprising applying a biasing charge through the ionic fluid and in a direction transverse to the flow direction to ionize the ionic fluid in a direction from the first and second sensing elements opposite the flow direction.

18. The method according to claim 17, wherein the biasing charge is applied with a pair of biasing electrodes aligned and spaced apart in a direction transverse to the flow direction and transverse to the alignment of the first and second sensing elements.

19. The method according to claim 18, wherein the sensor further comprises a third sensing element aligned with the first and second sensing elements in the flow direction and spaced apart from the first and second sensing elements in the flow direction, the pair of biasing electrodes are between the third sensing element and the first and second sensing elements, and the method further comprises applying an alternating current through the ionic fluid and from the third sensing element to one of the first and second sensing elements in the flow direction.