Cellulosic-based resistance domain for an analyte sensor
First Claim
1. An implantable glucose sensor for measuring a concentration of glucose in a host, the sensor comprising an electroactive surface and a membrane system disposed thereon, wherein the membrane system comprises a macromolecular resistance domain configured to control a flux of glucose therethrough, wherein the membrane is configured to use oxygen from a biological fluid surrounding the membrane to catalyze a reaction of glucose and oxygen, and wherein the macromolecular resistance domain comprises at least one hydrophilic moiety and at least one hydrophobic moiety;
- wherein the sensor is configured for implantation into a host, and wherein the sensor in vitro is capable of obtaining substantial linearity at glucose concentrations of from about 40 mg/dL to about 400 mg/dL at an oxygen concentration of about 0.25 mg/L.
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Abstract
The present invention relates generally to devices for measuring an analyte in a host. More particularly, the present invention relates to devices for measurement of glucose in a host that incorporate a cellulosic-based resistance domain.
648 Citations
23 Claims
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1. An implantable glucose sensor for measuring a concentration of glucose in a host, the sensor comprising an electroactive surface and a membrane system disposed thereon, wherein the membrane system comprises a macromolecular resistance domain configured to control a flux of glucose therethrough, wherein the membrane is configured to use oxygen from a biological fluid surrounding the membrane to catalyze a reaction of glucose and oxygen, and wherein the macromolecular resistance domain comprises at least one hydrophilic moiety and at least one hydrophobic moiety;
- wherein the sensor is configured for implantation into a host, and wherein the sensor in vitro is capable of obtaining substantial linearity at glucose concentrations of from about 40 mg/dL to about 400 mg/dL at an oxygen concentration of about 0.25 mg/L.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. An implantable glucose sensor for measuring glucose in a host, the sensor comprising an electroactive surface and a membrane system disposed thereon, wherein the membrane is configured to use oxygen from a biological fluid surrounding the membrane to catalyze a reaction of glucose and oxygen, wherein the membrane system comprises a resistance domain configured to control a flux of glucose therethrough, and wherein the resistance domain incorporates hydrophilic substituents and hydrophobic substituents to form a macromolecular structure;
- wherein the sensor is configured for implantation into a host, and wherein the sensor in vitro is capable of obtaining substantial linearity at glucose concentrations of from about 40 mg/dL to about 400 mg/dL at an oxygen concentration of about 0.25 mg/L.
- View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
Specification