Cellulosic-based resistance domain for an analyte sensor

• US 8,744,546 B2
• Filed: 04/28/2006
• Issued: 06/03/2014
• Est. Priority Date: 05/05/2005
• Status: Active Grant

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Petisce, James R., Woo, Kum Ming, Ha, Victor, Nicholas, Melissa
• Primary Examiner(s): Natnithithadha, Navin
• Application Number:
  US11/413,238
• Publication Number:
  US 20060253012A1
• Time in Patent Office: 2,958 Days
• Field of Search: 600/309, 600345-366, 422/50, 422/68.1, 204/400, 204/403.01
• US Class Current: 600/347
• CPC Class Codes: A61B 5/076 Permanent implantations telemetry using implanted circuitry A61B5/0031; implanted stimulators for therapy A61N1/3605, A61N1/362, A61N1/372
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14503 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/6848 Needles
• CPC Class Codes: B05D 1/005 Spin coating
• CPC Class Codes: B05D 1/02 performed by spraying
• CPC Class Codes: C12Q 1/002 Electrode membranes
• CPC Class Codes: C12Q 1/003 Functionalisation
• CPC Class Codes: G01N 33/54393 Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
• CPC Class Codes: G01N 33/66 involving blood sugars, e.g. galactose

Abstract

The present invention relates generally to devices for measuring an analyte in a host. More particularly, the present invention relates to devices for measurement of glucose in a host that incorporate a cellulosic-based resistance domain.

Claims

1. An implantable glucose sensor for measuring a concentration of glucose in a host, the sensor comprising an electroactive surface and a membrane system disposed thereon, wherein the membrane system comprises a macromolecular resistance domain configured to control a flux of glucose therethrough, wherein the membrane is configured to use oxygen from a biological fluid surrounding the membrane to catalyze a reaction of glucose and oxygen, and wherein the macromolecular resistance domain comprises at least one hydrophilic moiety and at least one hydrophobic moiety;

wherein the sensor is configured for implantation into a host, and wherein the sensor in vitro is capable of obtaining substantial linearity at glucose concentrations of from about 40 mg/dL to about 400 mg/dL at an oxygen concentration of about 0.25 mg/L.

2. The sensor of claim 1, wherein the hydrophobic moiety is selected from the group consisting of acetyl, butyryl, propionyl, methoxy, ethoxy, and propoxy.

3. The sensor of claim 2, wherein the hydrophobic moiety is acetyl.

4. The sensor of claim 3, wherein the macromolecular resistance domain comprises less than about 35 wt. % acetyl.

5. The sensor of claim 1, wherein the hydrophilic moiety is selected from the group consisting of hydroxyl, carboxymethyl, and carboxyethyl.

6. The sensor of claim 5, wherein the hydrophilic moiety is hydroxyl.

7. The sensor of claim 6, wherein the macromolecular resistance domain comprises at least about 7 wt. % hydroxyl.

8. The sensor of claim 1, wherein the sensor is a needle sensor configured for transcutaneous insertion into the host.

9. The sensor of claim 1, wherein the sensor is configured for wholly implanting into the host.

10. The sensor of claim 1, wherein the sensor is configured for implantation into a host tissue, and wherein the resistance domain is configured to interface with the host tissue.

11. The sensor of claim 1, wherein the resistance domain is a bioprotective barrier configured to protect the sensor from cellular invasion.

12. The sensor of claim 1, wherein the membrane system is an ionizing radiation-treated membrane system.

13. An implantable glucose sensor for measuring glucose in a host, the sensor comprising an electroactive surface and a membrane system disposed thereon, wherein the membrane is configured to use oxygen from a biological fluid surrounding the membrane to catalyze a reaction of glucose and oxygen, wherein the membrane system comprises a resistance domain configured to control a flux of glucose therethrough, and wherein the resistance domain incorporates hydrophilic substituents and hydrophobic substituents to form a macromolecular structure;

wherein the sensor is configured for implantation into a host, and wherein the sensor in vitro is capable of obtaining substantial linearity at glucose concentrations of from about 40 mg/dL to about 400 mg/dL at an oxygen concentration of about 0.25 mg/L.

14. The sensor of claim 13, wherein the hydrophobic substituent is selected from the group consisting of acetyl, butyryl, propionyl, methoxy, ethoxy, and propoxy.

15. The sensor of claim 13, wherein the hydrophobic substituent is acetyl.

16. The sensor of claim 15, wherein the macromolecular resistance domain comprises less than about 35 wt. % acetyl.

17. The sensor of claim 13, wherein the hydrophilic substituent is selected from the group consisting of hydroxyl, carboxymethyl, and carboxyethyl.

18. The sensor of claim 13, wherein the hydrophilic moiety is hydroxyl.

19. The sensor of claim 18, wherein the macromolecular resistance domain comprises at least about 7 wt. % hydroxyl.

20. The sensor of claim 13, wherein the sensor is a needle sensor configured for transcutaneous insertion into the host.

21. The sensor of claim 13, wherein the sensor is configured for implantation into a host tissue, and wherein the resistance domain is configured to interface with the host tissue.

22. The sensor of claim 13, wherein the resistance domain is a bioprotective barrier configured to protect the sensor from cellular invasion.

23. The sensor of claim 13, wherein the membrane system is an ionizing radiation-treated membrane system.