Optical stimulation of the brainstem and/or midbrain, including auditory areas

• US 8,744,570 B2
• Filed: 01/25/2010
• Issued: 06/03/2014
• Est. Priority Date: 01/23/2009
• Status: Active Grant

• Current Assignee: Massachusetts Eye And Ear Infirmary (Foundation of The Massachusetts Eye and EAR Infirmary Incorporated), Nurotone Medical Ltd.
• Original Assignee: Lockheed Martin Corporation (Martin Marietta Corporation)
• Inventors: Lee, Daniel J., Wells, Jonathon D.
• Primary Examiner(s): Gedeon, Brian T
• Application Number:
  US12/693,427
• Publication Number:
  US 20100292758A1
• Time in Patent Office: 1,590 Days
• Field of Search: 607 1- 3, 607 53- 57, 607/115, 607/116
• US Class Current: 607/3
• CPC Class Codes: A61N 1/36038 Cochlear stimulation
• CPC Class Codes: A61N 2005/063 comprising light transmitting means, e.g. optical fibres
• CPC Class Codes: A61N 2005/0659 infrared
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/0622 Optical stimulation for exciting neural tissue
• CPC Class Codes: A61N 5/067 using laser light

Abstract

Apparatus and method for optical- or optical-and-electrical stimulation of midbrain and/or brainstem tissue (e.g., auditory nerve pathways). Peripheral neural stimulation using infrared lasers has been demonstrated in several systems; however, optical stimulation of the central nervous system (CNS) has not been previously described. In some embodiments of the present invention, radiant energy exposure of the cochlear nucleus using a mid-wavelength infrared laser generates optically-evoked auditory brainstem responses (oABRs). In an experiment, the cochlear nuclei of adult male Sprague-Dawley rats were exposed using a suboccipital craniotomy approach. In one embodiment, different regions of left cochlear nucleus were acutely stimulated with a 200- or 400-micron-diameter optical fiber placed on the surface of the brainstem, using 50- to 750-microsecond pulses of 1849-nm to 1865-nm-wavelength radiation at a rate of 10 to 40 Hz and power levels ranging from 10% to 80% of 5 watts. oABRs were recorded during the period of optical stimulation.

Claims

1. A method for stimulating neurons of a brainstem or midbrain of a patient to provide sensations for the patient, the method comprising:

generating a plurality of light signals that, when applied to a neuron of a person, directly stimulates a nerve action potential in the neuron;

delivering the light signals to a plurality of neurons of the brainstem or midbrain of the patient;

selectively controlling the plurality of light signals to directly optically stimulate the plurality of neurons in order to control nerve action potentials (NAPs) produced by the plurality of neurons;

receiving sensed electromagnetic-radiation data indicative of a color; and

processing the received electromagnetic-radiation data to obtain color information, wherein the delivering of light signals comprises delivering the light pulses to a vision portion of the brainstem or midbrain of the patient to provide a sensation of the color to the patient.

2. The method of claim 1, the method further comprising:

receiving image data; and

processing the received image data to detect object-pattern information including vertical-object, horizontal-object, diagonal-object, and curved-object pattern information, wherein the delivering of light signals further comprises delivering the light pulses to a vision portion of the brainstem or midbrain of the patient to provide a sensation of the pattern to the patient.

4. The method of claim 2, further comprising delivering an electrical signal to the plurality of neurons of the auditory portion of the brainstem or midbrain of the patient, such that a combination of the electrical signal and the light signals stimulate the nerve action potentials in the plurality of neurons.

3. A method for stimulating neurons of a brainstem or midbrain of a patient to provide sensations for the patient, the method comprising:

generating a plurality of light signals that, when applied to a neuron of a person, can stimulate a nerve action potential in the neuron;

delivering the light signals to a plurality of neurons of the brainstem or midbrain of the patient;

selectively controlling the plurality of light signals to directly optically stimulate the plurality of neurons in order to control nerve action potentials (NAPs) produced by the plurality of neurons;

receiving an audio signal; and

processing the received audio signal to obtain frequency and intensity information, wherein the delivering of light signals comprises delivering the light pulses to an auditory portion of the brainstem or midbrain of the patient, and wherein the selectively controlling of the light signals includes selectively controlling the light signals to emit light pulses to selected locations of the brainstem or midbrain of the patient based on the frequency information and at selected pulse-repetition rates based on the intensity information.

5. The method of claim 3, wherein the delivering of light signals further includes delivering infrared light from a laser.

6. The method of claim 3, wherein the delivering of light signals further includes delivering infrared light from a vertical-cavity surface-emitting laser (VCSEL).

7. The method of claim 3, wherein the delivering of light signals further includes delivering the light signals to peripheral projections of the neurons.

8. The method of claim 3, wherein the delivering of light signals further includes delivering the light signals to central portions of the neurons.

9. The method of claim 3, wherein the delivering of the light signals further includes obtaining a plurality of light signals from one or more laser light sources and delivering the obtained light signals to discrete portions of excitable tissues, said signals being interpretable by the patient'"'"'s brain as sensory responses.

10. The method of claim 3, wherein the delivering of the light signals further includes selectively controlling the light signals to optically stimulate the plurality of neurons in order to control nerve action potentials (NAPs) produced by the plurality of neurons.

11. An apparatus comprising:

one or more light sources that are configured to generate a plurality of pulsed light signals that, when applied to a neuron of a person, directly stimulates a nerve action potential in the neuron;

a transmission medium configured to transmit the plurality of light signals from the one or more light sources to a plurality of neurons of a brainstem or midbrain of a living animal to provide auditory sensations for the living animal; and

a controller operatively coupled to the one or more light sources to selectively control the plurality of pulsed light signals from each of the one or more light sources such that the light signals provide controlled optical stimulation directly to the plurality of neurons in order to control nerve action potentials (NAPs) produced by the plurality of neurons, wherein the controller processes a received audio signal to obtain frequency and intensity information, and uses the transmission medium to deliver the pulsed light signals to selected locations of the brainstem or midbrain of the patient based on the frequency information, and wherein the controller controls the pulsed light signals at selected pulse-repetition rates based on the intensity information.

12. The apparatus of claim 11, wherein the control of the light signals provided by the controller includes selective control of a duty cycle of the plurality of light signals.

13. The apparatus of claim 11, wherein the control of the light signals provided by the controller includes selective control of a wavelength of the plurality of light signals.

14. The apparatus of claim 11, wherein the transmission medium includes a plurality of optical-signal-transmission channels.

15. The apparatus of claim 14, wherein the transmission medium includes a plurality of optical fibers each of which carries a different signal.

16. The apparatus of claim 11, further comprising a microphone having a signal output operatively coupled to a wireless transmitter that is configured to transmit information based on the microphone signal to the controller.

17. The apparatus of claim 16, the microphone further comprising a processor that is configured to receive a sound signal and based on the sound signal to generate information used by the controller to generate stimulation pulses configured to be interpretable by the living animal'"'"'s brain as having one or more frequency components and an intensity, in order to encode hearing.

18. The apparatus of claim 11, wherein the one or more light sources includes a plurality of vertical-cavity surface-emitting lasers (VCSELs).

19. The apparatus of claim 11, wherein the transmission medium includes an optical fiber.

20. An apparatus for stimulating neurons of a brainstem or midbrain of a patient to provide sensations for the patient, the apparatus comprising:

means for generating a plurality of light signals that, when applied to a neuron of a person, directly stimulates a nerve action potential in the neuron;

means for delivering the light signals to a plurality of neurons of the brainstem or midbrain of the patient; and

means for selectively controlling the plurality of light signals to directly optically stimulate the plurality of neurons in order to control nerve action potentials (NAPs) produced by the plurality of neurons;

means for receiving sensed electromagnetic-radiation data indicative of a color; and

means for processing the received electromagnetic-radiation data to obtain color information, wherein the means for delivering of light signals comprises means for delivering the light pulses to a vision portion of the brainstem or midbrain of the patient to provide a sensation of the color to the patient.

21. An apparatus for stimulating neurons of a brainstem or midbrain of a patient to provide sensations for the patient, the apparatus comprising:

means for generating a plurality of light signals that, when applied to a neuron of a person, directly stimulates a nerve action potential in the neuron;

means for delivering the light signals to a plurality of neurons of the brainstem or midbrain of the patient;

means for selectively controlling the plurality of light signals to directly optically stimulate the plurality of neurons in order to control nerve action potentials (NAPs) produced by the plurality of neurons;

means for receiving an audio signal; and

means for processing the received audio signal to obtain frequency and intensity information, wherein the delivering of light signals comprises delivering the light pulses to an auditory portion of the brainstem or midbrain of the patient, and wherein the means for selectively controlling of the light signals includes means for selectively controlling the light signals to emit light pulses to selected locations of the brainstem or midbrain of the patient based on the frequency information and at selected pulse-repetition rates based on the intensity information.

22. The apparatus of claim 21, further comprising means for delivering an electrical signal to the plurality of neurons of the auditory portion of the brainstem or midbrain of the patient, such that a combination of the electrical signal and the light signals stimulate the nerve action potentials in the plurality of neurons.