Method for determining analyte concentration based on complex index functions
First Claim
1. A method for determining an analyte concentration in a sample, comprising:
- (a) applying the sample to a test sensor;
(b) applying an electrical or optical input signal to the sample;
(c) measuring at least one uncompensated output signal value i from the sample, wherein the value i is responsive to an undetermined concentration of the analyte in the sample;
(d) determining at least one slope deviation Δ
S value from a first complex index function f(CIndex) including at least a first term and a second term, whereinthe first term includes a product of a first weighing coefficient and at least a first error parameter; and
the second term includes a product of a second weighing coefficient and at least a second error parameter;
(e) determining a corrected analyte concentration Acorr in the sample from the at least one uncompensated output signal value by adjusting a previously determined reference slope Scal with the at least one slope deviation Δ
S value and combining the adjusted slope with the at least one uncompensated output signal value,wherein steps (d) and (e) are performed by a processor using computer readable software code.
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Abstract
A biosensor system determines analyte concentration from an output signal generated from a light-identifiable species or a redox reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals or determined analyte concentrations with one or more complex index function extracted from the output signals or from other sources. The complex index functions determine at least one slope deviation value, ΔS, or normalized slope deviation from one or more error parameters. The slope-adjusted correlation between analyte concentrations and output signals may be used to determine analyte concentrations having improved accuracy and/or precision from output signals including components attributable to bias.
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Citations
19 Claims
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1. A method for determining an analyte concentration in a sample, comprising:
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(a) applying the sample to a test sensor; (b) applying an electrical or optical input signal to the sample; (c) measuring at least one uncompensated output signal value i from the sample, wherein the value i is responsive to an undetermined concentration of the analyte in the sample; (d) determining at least one slope deviation Δ
S value from a first complex index function f(CIndex) including at least a first term and a second term, whereinthe first term includes a product of a first weighing coefficient and at least a first error parameter; and the second term includes a product of a second weighing coefficient and at least a second error parameter; (e) determining a corrected analyte concentration Acorr in the sample from the at least one uncompensated output signal value by adjusting a previously determined reference slope Scal with the at least one slope deviation Δ
S value and combining the adjusted slope with the at least one uncompensated output signal value,wherein steps (d) and (e) are performed by a processor using computer readable software code. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification