Non-invasive method for diagnosing the severity of heart failure by extracting and analyzing acetone concentrations in captured exhaled breath
First Claim
1. A non-invasive method of diagnosing heat failure, comprising:
- (a) collecting a sample of exhaled air using a capture device comprising;
(i) means for capturing the exhaled air directly from a patient;
(ii) means for extracting and capturing volatile compound(s) from the captured exhaled air of the patient especially a biomarker of interest;
(iii) means of diffusing the captured exhaled air into means for capturing a biomarker;
(iv) means for indirectly cooling the capturing means;
(v) means of insulating said capture device from external conditions; and
,(vi) means for reading total volume of exhaled air collected;
b) analyzing, using a processor, the sample of captured exhaled air for acetone as a biomarker of heart failure, wherein the detection and quantification of the acetone can be made by any suitable technique selected from the group consisting of chromatography, mass spectrometry, infra-red or ultra-violet spectrophotometry, gas sensors and electronic noses; and
c) indicating, using the processor, the severity of heart failure in accordance with the following ranges of acetone in the sample of exhaled air;
(i) acetone concentration with an upper limit of 0.85 mcg/L indicates that the patient does not have a heart failure condition;
(ii) acetone concentration with lower and upper limits of 0.85 mcg/L and 2.6 mcg/L indicates compensated heart failure; and
(iii) acetone concentration with a lower limit of 2.6 mcg/L indicates decompensated heart failure, characterized by heart failure with congestion and/or heart failure with low output.
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Accused Products
Abstract
The invention application presents a fast, efficient, reproductive alternative of a non-invasive method for diagnosing the severity of heart failure based on a specific biomarker. An additional object of the present invention is a collector device for the biomarker from exhaled breath that is portable, simple, low cost and does not need to run on electric power. This invention advantageously permits the replacement of invasive diagnosis methods, favoring the patient'"'"'s comfort in addition to the agility and speed of medical attention at hospitals, and may become a standard method for all suspected cases of circulatory disease and heart failure and, more specifically, decompensated heart failure.
27 Citations
25 Claims
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1. A non-invasive method of diagnosing heat failure, comprising:
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(a) collecting a sample of exhaled air using a capture device comprising; (i) means for capturing the exhaled air directly from a patient; (ii) means for extracting and capturing volatile compound(s) from the captured exhaled air of the patient especially a biomarker of interest; (iii) means of diffusing the captured exhaled air into means for capturing a biomarker; (iv) means for indirectly cooling the capturing means; (v) means of insulating said capture device from external conditions; and
,(vi) means for reading total volume of exhaled air collected; b) analyzing, using a processor, the sample of captured exhaled air for acetone as a biomarker of heart failure, wherein the detection and quantification of the acetone can be made by any suitable technique selected from the group consisting of chromatography, mass spectrometry, infra-red or ultra-violet spectrophotometry, gas sensors and electronic noses; and c) indicating, using the processor, the severity of heart failure in accordance with the following ranges of acetone in the sample of exhaled air; (i) acetone concentration with an upper limit of 0.85 mcg/L indicates that the patient does not have a heart failure condition; (ii) acetone concentration with lower and upper limits of 0.85 mcg/L and 2.6 mcg/L indicates compensated heart failure; and (iii) acetone concentration with a lower limit of 2.6 mcg/L indicates decompensated heart failure, characterized by heart failure with congestion and/or heart failure with low output. - View Dependent Claims (7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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2. A non-invasive method of prognosticating heat failure, comprising:
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(a) collecting a sample of exhaled air using a capture device comprising; (i) means for capturing the exhaled air directly from a patient; (ii) means for extracting and capturing volatile compound(s) from the captured exhaled air of the patient especially a biomarker of interest; (iii) means of diffusing the captured exhaled air into means for capturing a biomarker; (iv) means for indirectly cooling the capturing means; (v) means of insulating said capture device from external conditions; and
,(vi) means for reading total volume of exhaled air collected; b) analyzing, using a processor, the sample of captured exhaled air for acetone as a biomarker of heart failure, wherein the detection and quantification of the acetone can be made by any suitable technique selected from the group consisting of chromatography, mass spectrometry, infra-red or ultra-violet spectrophotometry, gas sensors and electronic noses; and c) indicating, using the processor, the prognosis of the patient suffering from decompensated heart failure in accordance with the following ranges of acetone in the sample of exhaled air; (i) acetone concentration with an upper limit of 0.85 mcg/L indicates that the patient does not have a heart failure condition; (ii) acetone concentration with lower and upper limits of 0.85 mcg/L and 2.6 mcg/L indicates compensated heart failure; and (iii) acetone concentration with a lower limit of 2.6 mcg/L indicates decompensated heart failure, characterized by heart failure with congestion and/or heart failure with low output. - View Dependent Claims (3, 4, 5, 6, 18, 19, 20, 21, 22, 23, 24, 25)
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Specification