Method and apparatus for fluid delivery

• US 8,747,371 B2
• Filed: 03/12/2007
• Issued: 06/10/2014
• Est. Priority Date: 03/13/2006
• Status: Expired due to Fees

• Current Assignee: Renishaw PLC
• Original Assignee: Renishaw PLC
• Inventors: Gill, Steven Streatfield
• Primary Examiner(s): SHUMATE, VICTORIA PEARL
• Application Number:
  US12/224,655
• Publication Number:
  US 20090030373A1
• Time in Patent Office: 2,647 Days
• Field of Search: 6048901-8921, 604/93.01, 604/175, 60428801-27704, 604/174, 604/258, 604/523, 604/538, 604/533
• US Class Current: 604/288.01
• CPC Class Codes: A61M 2039/0205 for injecting media
• CPC Class Codes: A61M 2039/0229 having means for facilitating assembling, e.g. snap-fit housing or modular design
• CPC Class Codes: A61M 2039/0232 having means for facilitating the insertion into the body
• CPC Class Codes: A61M 2039/025 through bones or teeth, e.g. through the skull
• CPC Class Codes: A61M 2039/1066 having protection means, e.g. sliding sleeve to protect connector itself, shrouds to protect a needle present in the connector, protective housing, isolating sheath
• CPC Class Codes: A61M 2205/04 implanted
• CPC Class Codes: A61M 2210/0693 Brain, cerebrum
• CPC Class Codes: A61M 39/0208 Subcutaneous access sites for injecting or removing fluids transcutaneous access sites A61M39/0247; implantable infusion devices A61M5/14276
• CPC Class Codes: A61M 39/0247 Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body peritoneal dialysis catheters A61M1/285; tracheostomy devices A61M16/0465; measuring pressure within the body A61B5/03; colostomy devices A61F5/445; gastrotomy feeding tubes A61J15/0015; means for fixing a feeding tube outside of the body A61J15/0053
• CPC Class Codes: A61M 39/10 Tube connectors; Tube couplings A61M39/02 takes precedence; connecting needles to syringes or hubs A61M5/34; connecting catheter tubes to hubs A61M25/0014
• CPC Class Codes: A61M 5/14 Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
• CPC Class Codes: A61M 5/1408 in parallel, e.g. manifolds, sequencing valves access sites A61M39/02; tube connectors A61M39/10
• CPC Class Codes: A61M 5/142 Pressure infusion, e.g. using pumps
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body

Abstract

Fluid delivery apparatus is described for the delivery of fluids to regions of the body, especially for delivery to regions of the brain. The apparatus includes a first length of implantable tubing having a first end and a first fluid connector portion attached to the first end of the first length of implantable tubing. The first fluid connector portion is releaseably connectable to a complementary second fluid connector portion. An implantable housing is also provided for enclosing and protecting the first fluid connector portion. The implantable housing is openable to provide access to the first fluid connector portion. For example, the housing may have a hinged lid or cover portion. A corresponding method is also described.

Claims

1. A method of drug delivery, comprising:

providing a fluid delivery apparatus to be surgically implanted into a subject, the apparatus including;

a first length of implantable tubing having a first end;

a first fluid connector portion attached to the first end of the first length of implantable tubing, the first fluid connector portion being releasably connectable to a complementary second fluid connector portion; and

an implantable housing configured to enclose the first fluid connector portion,

the implantable housing including a body portion having an opening through which the first fluid connector portion can be accessed and a cover configured to open and close the opening a plurality of times;

surgically implanting, entirely subcutaneously, the first length of implantable tubing, the first fluid connector portion, and the implantable housing into the subject; and

delivering a drug to the subject through the first length of implantable tubing.

2. The method according to claim 1, wherein the cover is attached to the body portion by a hinge.

3. The method according to claim 1, wherein the cover is attached to the body portion by a screw thread.

4. The method according to claim 1, wherein the implantable housing, when closed, protects the first fluid connector portion.

5. The method according to claim 1, wherein the implantable housing defines a cavity for enclosing a coil of the first length of tubing.

6. The method according to claim 1, wherein a sealing member prevents fluid egress from the first end of the first length of tubing when the first fluid connector portion is unattached to the complementary second fluid connector portion.

7. The method according to claim 1, wherein the first fluid connector portion is arranged to provide a substantially sterile fluidic connection with the complementary second fluid connector portion.

8. The method according to claim 1, wherein the implantable housing is configured for subcutaneous implantation in the torso.

9. The method according to claim 1, wherein the first length of tubing comprises a bundle of one or more single lumen tubes encased in a protective sheath.

10. The method according to claim 1, wherein the first length of tubing comprises N lumens, wherein N equals at least two.

11. The method according to claim 10, wherein a first fluid router is attached to the second end of the first length of tubing, the first fluid router being arranged to establish fluid communication between each of the N lumens of the first length of tubing and N output ports.

12. The method according to claim 11, wherein N catheters are provided, each of the N catheters being in fluid communication with an output port of the first fluid router.

13. The method according to claim 12, wherein each of the N catheters is suitable for delivery of fluid to a central nervous system.

14. The method according to claim 11, wherein the first fluid router is skull mountable.

15. The method according to claim 1, wherein the first fluid connector portion comprises a plurality of chambers, each of the plurality of chambers comprising a septum seal through which a needle can be passed.

16. The method according to claim 1, further comprising:

providing a second length of tubing having a first end; and

attaching the complementary second fluid connector portion to the first end of the second length of tubing, the complementary second fluid connector portion being releasably connected to the first fluid connector portion.

17. The method according to claim 16, wherein the second fluid connector portion comprises one or more hollow needles.

18. The method according to claim 16, wherein the second length of tubing comprises a bundle of one or more single lumen tubes encased in a protective sheath.

19. The method according to claim 16, wherein the second length of tubing comprises M lumens, wherein M equals at least two.

20. The method according to claim 19, wherein a second fluid router is attached to the second end of the second length of tubing, the second fluid router being arranged to establish fluid communication between each of the M lumens of the second length of tubing and M input ports.

21. The method according to claim 20, wherein an external pump assembly is provided for pumping fluid into any one or more of the M input ports of the second fluid router.

22. A method of drug delivery, comprising:

taking a subject having a first part of a modular fluid delivery apparatus implanted therein, the first part of the modular fluid delivery apparatus comprising;

a first length of tubing having a first end and a second end,

a first fluid connector portion attached to the first end of the first length of tubing,

one or more catheters connected to the second end of the first length of tubing, and implanted to deliver fluid to one or more anatomical sites within the subject, and

a housing enclosing the first fluid connector portion, the housing comprising a body portion having an opening through which the first fluid connector portion can be accessed and a cover configured to open and close the opening a plurality of times; and

taking a second part of the modular fluid delivery apparatus, the second part comprising a second length of tubing having a third end comprising a second fluid connector portion;

performing a surgical procedure to make an incision in the subject to uncover the housing, opening the cover to gain access to the first fluid connector portion of the first part of the modular fluid delivery apparatus that is located within the housing, and connecting the first fluid connector portion to the second fluid connector portion.

23. The method according to claim 22, further comprising pumping fluid to the one or more implanted catheters through the first and second parts of the modular fluid delivery apparatus.

24. The method according to claim 23, further comprising disconnecting the first fluid connector portion from the second fluid connector portion and completely withdrawing the second part of the modular fluid delivery apparatus from the subject.

25. The method according to claim 24, wherein the taking the second part, the pumping and the disconnecting steps are repeated in sequence a plurality of times.

26. The method according to claim 22, wherein the taking the subject having the first part step further comprises implanting the first part of the modular fluid delivery apparatus in the subject.

27. The method according to claim 26, wherein the taking the subject having the first part step further comprises implanting a plurality of catheters in the brain of the subject.

28. A method of using a fluid delivery apparatus, comprising:

providing a fluid delivery apparatus to be surgically implanted into a subject, the apparatus including;

a first length of implantable tubing having a first end;

a first fluid connector portion attached to the first end of the first length of implantable tubing, the first fluid connector portion being releasably connectable to a complementary second fluid connector portion; and

an implantable housing configured to enclose the first fluid connector portion,

the implantable housing including a body portion having an opening through which the first fluid connector portion can be accessed and a cover configured to open and close the opening a plurality of times;

surgically implanting, entirely subcutaneously, the first length of implantable tubing, the first fluid connector portion, and the implantable housing into the subject;

making an incision in the subject; and

removably connecting the second fluid connector portion to the first fluid connector portion through the incision.