Administration of antibiotics and therapeutic agents
First Claim
Patent Images
1. A method for treating a bacterial infection in a soft tissue in a patient, comprising:
- identifying a soft tissue in a patient as comprising a bacterial infection;
delivering one or more antibiotics dissolved in solution to the infected tissue via subcutaneous injection, wherein the one or more antibiotics are not encapsulated in vesicles; and
broadcasting ultrasonic energy at about 2.5 to 4 W/cm2 and at a frequency of 0.5 to 5 MHz transcutaneously to the soft tissue to disperse the antibiotics in the infected tissue via microstreaming by cavitation, thereby treating the infection, wherein the ultrasonic energy is broadcast for about 2 to 5 minutes.
1 Assignment
0 Petitions
Accused Products
Abstract
Antibiotics are administered in a surgical site subcutaneously via a small or stab incision in the surgical field. Transcutaneous ultrasonic vibrations are applied across the surgical field, which is then opened in the usual manner, to thereby provide a surgical field which contains a vastly higher and more effective level of antibiotic. At the same time the underlying tissue is hydrated.
-
Citations
21 Claims
-
1. A method for treating a bacterial infection in a soft tissue in a patient, comprising:
-
identifying a soft tissue in a patient as comprising a bacterial infection; delivering one or more antibiotics dissolved in solution to the infected tissue via subcutaneous injection, wherein the one or more antibiotics are not encapsulated in vesicles; and broadcasting ultrasonic energy at about 2.5 to 4 W/cm2 and at a frequency of 0.5 to 5 MHz transcutaneously to the soft tissue to disperse the antibiotics in the infected tissue via microstreaming by cavitation, thereby treating the infection, wherein the ultrasonic energy is broadcast for about 2 to 5 minutes. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
-
-
10. A method of treating a methicilin-resistant Staphylococcus aureus (MRSA) infection in a patient comprising:
-
identifying an infected tissue in the patient comprising MRSA; injecting subcutaneously one or more antibiotics dissolved in solution into the infected tissue, wherein the antibiotics are not encapsulated in vesicles; and dispersing the antibiotics in the infected tissue via microstreaming by transcutaneously applying ultrasound to the tissue at a power density of about 3 W/cm2 and a frequency of 0.5 to 5 MHz, wherein the ultrasound is applied to the tissue for about 2 to 5 minutes. - View Dependent Claims (11, 12, 13, 14, 15, 16)
-
-
17. A method for administering one or more therapeutic agents to a target soft tissue in a patient, comprising:
-
delivering a fluid comprising one or more therapeutic agents dissolved in solution via subcutaneous injection to the target soft tissue, wherein the therapeutic agents are not encapsulated in vesicles; and providing an energy field at about 2.5 to 4 W/cm2 and at a frequency of 0.5 to 5 MHz transcutaneously to the target tissue to disperse the therapeutic agent in the target soft tissue via microstreaming by cavitation, wherein the energy field is provided to the target tissue for about 2 to 5 minutes, and wherein the concentration of therapeutic agent in a sample of the patients serum following dispersal of the therapeutic agent is 10 times less than the contemporaneous concentration in the target tissue. - View Dependent Claims (18, 19, 20, 21)
-
Specification