Multi-well rotary synthesizer
First Claim
1. A vial comprising:
- a. a top opening having a circumference;
b. a bored interior to hold a frit for retaining material within the vial above the frit;
c. a solid support retained within the vial above the frit after a flushing procedure; and
d. a protruding support that extends along the entire circumference of the top opening of the vial and is configured to form a pressure tight seal directly between the vial and a cartridge when the vial is placed in the cartridge.
2 Assignments
0 Petitions
Accused Products
Abstract
An apparatus for synthesizing polymer chains includes a controller, a plurality of precision fit vials circularly arranged in multiple banks on a cartridge, a drain corresponding to each bank of vials, a chamber bowl, a plurality of valves for delivering reagents to selective vials, and a waste tube system for purging material from the vials. A purging operation can be selectively performed on one or more of the banks of vials. The plurality of vials are stored in the cartridge and are divided among individual banks wherein each bank of vials has a corresponding drain. There is at least one waste tube system for expelling the reagent solution from vials within a particular bank of vials when the waste tube system is coupled to the corresponding drain. The cartridge holding the plurality of vials rotates relative to the stationary banks of valves and the waste tube system.
131 Citations
33 Claims
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1. A vial comprising:
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a. a top opening having a circumference; b. a bored interior to hold a frit for retaining material within the vial above the frit; c. a solid support retained within the vial above the frit after a flushing procedure; and d. a protruding support that extends along the entire circumference of the top opening of the vial and is configured to form a pressure tight seal directly between the vial and a cartridge when the vial is placed in the cartridge. - View Dependent Claims (2, 3, 4, 5, 6, 16, 17, 18, 19, 20, 21)
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7. A vial comprising:
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a. a frit; b. a solid support; and c. a body comprising; i. a bored interior to hold the frit for retaining the solid support above the frit, wherein the solid support and material formed on the solid support is retained above the frit, within the vial, during a flushing procedure; ii. a top opening having a circumference through which material is dispensed into the bored interior; iii. an exterior support that extends along the entire circumference of the top opening of the vial and is configured to form a pressure tight seal directly between the vial and a cartridge when the vial is placed in the cartridge. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14)
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15. A vial comprising:
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a. a top opening having a circumference; b. a bottom opening; c. an interior that holds a frit; d. a solid support within the vial that is retained above the frit; e. a support that extends along the entire circumference of the top opening of the vial and is configured to form a pressure tight seal directly between the vial and a cartridge when the vial is placed in the cartridge.
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22. A cartridge comprising:
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a. one or more receiving holes; and b. one or more vials each comprising; i. a top opening having a circumference; ii. a bored interior to hold a frit for retaining material within the vial above the frit; iii. a solid support retained within the vial above the frit after a flushing procedure; and iv. a protruding support that extends along the entire circumference of the top opening of the vial and is configured to form a pressure tight seal directly between the vial and the cartridge when the vial is placed in one of the receiving holes of the cartridge. - View Dependent Claims (23, 24, 25, 26, 27)
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28. A cartridge comprising:
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a. one or more receiving holes; and b. one or more vials each comprising; i. a frit; ii. a solid support; and iii. a body comprising; A. an interior to hold the frit for retaining the solid support above the frit, wherein the solid support and material formed on the solid support is retained above the frit, within the vial, during a flushing procedure; B. a top opening having a circumference through which material is dispensed into the bored interior; and C. an exterior support that extends along the entire circumference of the top opening of the vial and is configured to form a pressure tight seal directly between the vial and the cartridge when the vial is placed in one of the receiving holes of the cartridge. - View Dependent Claims (29, 30, 31, 32, 33)
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Specification