Oncolytic vaccinia virus combination cancer therapy
First Claim
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1. A method for treating cancer in a subject previously administered a Wyeth strain vaccinia virus lacking a functional thymidine kinase gene and expressing GM-CSF comprising administering an effective amount of an anti-angiogenic tyrosine kinase inhibitor at least 1 week and up to 13 weeks after the vaccinia virus therapy, wherein the anti-angiogenic tyrosine kinase inhibitor is sorafenib or sunitinib.
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Abstract
Embodiments of the invention are directed methods that include a thymidine kinase deficient vaccinia virus. The methods include evaluating a tumor for reperfusion after treatment with vaccinia virus and administering an anti-angiogenic agent if reperfusion is detected.
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15 Claims
- 1. A method for treating cancer in a subject previously administered a Wyeth strain vaccinia virus lacking a functional thymidine kinase gene and expressing GM-CSF comprising administering an effective amount of an anti-angiogenic tyrosine kinase inhibitor at least 1 week and up to 13 weeks after the vaccinia virus therapy, wherein the anti-angiogenic tyrosine kinase inhibitor is sorafenib or sunitinib.
Specification