Nasolacrimal drainage system implants for drug therapy
First Claim
Patent Images
1. An implant for insertion through a punctum and into a canalicular lumen of a patient, the implant comprising:
- a plug body comprising a drug insert;
the drug insert comprising;
a matrix of material;
a therapeutic agent dispersed in the matrix of material; and
a sheath disposed over a portion of the matrix of material and configured to inhibit the therapeutic agent from being released from the matrix of material into the canalicular lumen, wherein when the implant is inserted into the canalicular lumen an exposed surface of the drug insert is in direct contact with tear fluid to allow diffusion of the therapeutic agent from a surface of the matrix of material to a tear film; and
a retention structure configured to retain the implant within the canalicular lumen.
6 Assignments
0 Petitions
Accused Products
Abstract
An implant for insertion through a punctum and into a canalicular lumen of a patient. The implant includes a matrix of material, a therapeutic agent dispersed in the matrix of material, a sheath disposed over a portion of the matrix of material and configured to inhibit the therapeutic agent from being released from the matrix of material into the canalicular lumen and to allow the therapeutic agent to be released from a surface of the matrix of material to a tear film, and a retention structure configured to retain the implant within the canalicular lumen.
140 Citations
20 Claims
-
1. An implant for insertion through a punctum and into a canalicular lumen of a patient, the implant comprising:
-
a plug body comprising a drug insert; the drug insert comprising; a matrix of material; a therapeutic agent dispersed in the matrix of material; and a sheath disposed over a portion of the matrix of material and configured to inhibit the therapeutic agent from being released from the matrix of material into the canalicular lumen, wherein when the implant is inserted into the canalicular lumen an exposed surface of the drug insert is in direct contact with tear fluid to allow diffusion of the therapeutic agent from a surface of the matrix of material to a tear film; and a retention structure configured to retain the implant within the canalicular lumen. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
-
-
11. An implant for insertion into a punctum of a patient, the implant comprising:
-
a therapeutic agent; a body of material that holds the therapeutic agent; and an expandable retention structure disposed over at least a portion of the body of material, the expandable retention structure configured to retain the body of material near the punctum. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
-
Specification