1L1RL-1 as a cardiovascular disease marker and therapeutic target
First Claim
Patent Images
1. A method for predicting outcome of a cardiovascular condition in a subject having or suspected of having a cardiovascular condition and treating the subject, the method comprising:
- (a) performing an assay to determine a level of soluble ST2 in a sample from a subject having or suspected of having a cardiovascular condition;
(b) comparing the level of soluble ST2 in the sample to a predetermined value specific for predicting outcome of the cardiovascular condition;
(c) identifying a subject having an elevated level of soluble ST2 compared to the predetermined value as having an increased likelihood of a negative outcome of a cardiovascular condition as compared to a subject not having an elevated level of soluble ST2 compared to the predetermined value; and
(d) administering an agent for reducing the risk of a cardiovascular condition to the subject identified in (c).
1 Assignment
0 Petitions
Accused Products
Abstract
This invention pertains to methods and compositions for the diagnosis and treatment of cardiovascular conditions. More specifically, the invention relates to isolated molecules that can be used to diagnose and/or treat cardiovascular conditions including cardiac hypertrophy, myocardial infarction, stroke, arteriosclerosis, and heart failure.
-
Citations
41 Claims
-
1. A method for predicting outcome of a cardiovascular condition in a subject having or suspected of having a cardiovascular condition and treating the subject, the method comprising:
-
(a) performing an assay to determine a level of soluble ST2 in a sample from a subject having or suspected of having a cardiovascular condition; (b) comparing the level of soluble ST2 in the sample to a predetermined value specific for predicting outcome of the cardiovascular condition; (c) identifying a subject having an elevated level of soluble ST2 compared to the predetermined value as having an increased likelihood of a negative outcome of a cardiovascular condition as compared to a subject not having an elevated level of soluble ST2 compared to the predetermined value; and (d) administering an agent for reducing the risk of a cardiovascular condition to the subject identified in (c). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
-
-
22. A method for predicting outcome of a cardiovascular condition in a subject having or suspected of having a cardiovascular condition and treating the subject, the method comprising:
-
(a) performing an assay to determine a first level of soluble ST2 in a sample obtained at a first time point from a subject having or suspected of having a cardiovascular condition; (b) performing an assay to determine a second level of soluble ST2 in a sample obtained at a second time point from the subject; (c) comparing the second level of soluble ST2 to the first level of soluble ST2; (d) identifying a subject having an elevated second level of soluble ST2 compared to the first level of soluble ST2 as having an increased likelihood of a negative outcome of a cardiovascular condition as compared to a subject not having an elevated second level of soluble ST2 compared to the first level of soluble ST2; and (d) administering an agent for reducing the risk of a cardiovascular condition to the subject identified in (c). - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
-
Specification