Medical appliance having a slidable coating layer and syringe

• US 8,748,544 B2
• Filed: 09/30/2013
• Issued: 06/10/2014
• Est. Priority Date: 03/30/2011
• Status: Active Grant

• Current Assignee: Terumo Kabushiki Kaisha (Terumo Corporation)
• Original Assignee: Terumo Kabushiki Kaisha (Terumo Corporation)
• Inventors: Abe, Yoshihiko, Watanabe, Eiji
• Primary Examiner(s): Loewe, Robert S
• Application Number:
  US14/042,468
• Publication Number:
  US 20140031764A1
• Time in Patent Office: 253 Days
• Field of Search: None
• US Class Current: 525/477
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/14 Materials characterised by their function or physical properties , e.g. lubricating compositions
• CPC Class Codes: A61M 2005/3104 Caps for syringes without needle
• CPC Class Codes: A61M 2025/0046 Coatings for improving slidability
• CPC Class Codes: A61M 2025/09133 having specific material compositions or coatings; Materials with specific mechanical behaviours, e.g. stiffness, strength to transmit torque
• CPC Class Codes: A61M 2205/0222 Materials for reducing friction
• CPC Class Codes: A61M 5/31513 Piston constructions to improve sealing or sliding
• CPC Class Codes: C08L 83/04 Polysiloxanes
• CPC Class Codes: F16J 15/3284 characterised by their structure; Selection of materials

Abstract

A medical appliance including a slidable coating layer moves in contact with an inner surface of a medical member or that of a lumen. The medical appliance has the slidable coating layer formed at a part thereof which contacts the medical member or the lumen. The slidable coating layer is formed of a composition containing a solventless-type hardening silicone-based resin.

Claims

1. A medical appliance, comprising a slidable coating layer which moves while in contact with an inner surface of a medical member or an inner surface of a lumen,

wherein said slidable coating layer is formed at a part of the medical appliance which contacts said medical member or said lumen,

wherein said slidable coating layer is formed of a composition containing solventless hardening silicone-based resin.

2. The medical appliance having a slidable coating layer according to claim 1, wherein said composition does not contain a tin-based compound.

3. The medical appliance having a slidable coating layer according to claim 1, wherein said solventless hardening silicone-based resin has a viscosity of 30 to 500 mPa·

s at 25°

C. before said solventless hardening silicone-based resin hardens.

4. The medical appliance having a slidable coating layer according to claim 1, wherein said silicone-based resin of said composition is formed by hydrosilylation between said vinyl groups of said silicone having said vinyl groups and said branch structure and silicon bonded to said hydrogen groups of said silicone having said hydrogen groups bonded to said silicon atom.

5. The medical appliance having a slidable coating layer according to claim 1, wherein said silicone having said branch structure has a viscosity of 30 to 1,000 mPa·

s at 25°

C.

6. The medical appliance having a slidable coating layer according to claim 1, wherein said silicone having said branch structure is formed by polymerizing 1,3,5,7-tetravinyltetramethylcyclotetrasiloxane and/or octamethylcyclotetrasiloxane with 1,5-diethenyl-3,3-bis[(ethenyldimethylsilyl)oxy]-1,1,5,5-tetramethylpentanetrisiloxane.

7. The medical appliance having a slidable coating layer according to claim 1, wherein said silicone having said hydrogen groups bonded to said silicon atom is a homopolymer or a copolymer of polymethylhydrosiloxane having a trimethylsilyl group at both terminals thereof.

8. The medical appliance having a slidable coating layer according to claim 1, wherein said silicone having said hydrogen groups bonded to said silicon atom is a homopolymer or a copolymer of polydimethylsiloxane having a hydrogen group at both terminals thereof.

9. The medical appliance having a slidable coating layer according to claim 1, wherein said composition contains a platinum group metal-based catalyst.

10. The medical appliance having a slidable coating layer according to claim 1, wherein said composition contains alkyl alkoxy silane or phenylalkoxysilane and in addition, glycidoxy alkyl alkoxysilane.

11. The medical appliance having a slidable coating layer according to claim 1, wherein said composition contains alkoxysilane having an ureido group or an uraren group and/or a product formed by a reaction between alkoxysilane having an amino group and a carboxylic anhydride.

12. The medical appliance having a slidable coating layer according to claim 1, wherein said coating layer does not contain solid fine particles and an emulsifier.

13. The medical appliance having a slidable coating layer according to claim 1, wherein said solventless hardening silicone-based resin is a thermosetting silicone-based resin.

14. The medical appliance having a slidable coating layer according to claim 1, wherein said coating layer has a thickness of 1 to 30 μ

m.

15. The medical appliance having a slidable coating layer according to claim 1, wherein said medical appliance is a guide wire or a catheter.

16. The medical appliance having a slidable coating layer according to claim 1, wherein said medical member is an outer cylinder for a syringe,

wherein said medical appliance is a gasket for said syringe slidably accommodated inside said outer cylinder for said syringe, and

wherein said gasket has a gasket body made of an elastic body and said slidable coating layer formed on a part thereof which contacts at least said outer cylinder for said syringe.

17. The medical appliance having a slidable coating layer according to claim 16, wherein said medical member is a plastic outer cylinder for a syringe, and

wherein said medical appliance is a gasket for said plastic outer cylinder for said syringe.

18. A syringe, comprising:

an outer cylinder of said syringe;

a gasket of said syringe which is the medical appliance having a slidable coating layer according to claim 16,

wherein the gasket is slidably accommodated inside said outer cylinder.

19. The syringe according to claim 18, wherein the syringe is filled with a liquid medicine.

20. The syringe according to claim 18, wherein a dynamic sliding resistance value of said gasket is not more than 20 N when said gasket slides inside said outer cylinder at a low speed (100 mm/minute).

21. The syringe according to claim 18, wherein said outer cylinder is made of a plastic.

22. The syringe according to claim 18, further comprising a plunger which is mounted on said gasket.