Assay instrument for detecting optical signals from samples
First Claim
1. An assay instrument for detecting optical signals from samples, comprising:
- a sample stage comprising a first interface and a second interface, the first interface comprising a platform for holding a sample on an open-faced support and for imaging of an external surface and the second interface comprising a platform for holding a sample in a flow cell for imaging of at least one internal surface, wherein the sample stage is configured to couple to the flow cell with fluidics connectors;
an objective lens positioned proximate to the sample stage for imaging;
an optical detector for detecting optical signals from the open-faced support and flow cell; and
a moving mechanism for selectively moving one or more optical components into an optical pathway between the sample stage and the optical detector to either a first configuration for surface-imaging of the open-faced support or a second configuration for imaging the flow cell.
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Accused Products
Abstract
An optical system configured to detect optical signals during imaging sessions. The optical system includes an objective lens that has a collecting end that is positioned proximate to a sample and configured to receive optical signals therefrom. The optical system also includes a removable path compensator that is configured to be located at an imaging position between the collecting end of the objective lens and the sample. The path compensator adjusts an optical path of the light emissions when in the imaging position. Also, the optical system includes a transfer device that is configured to move the path compensator. The transfer device locates the path compensator at the imaging position for a first imaging session and removes the path compensator from the imaging position for a second imaging session.
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Citations
20 Claims
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1. An assay instrument for detecting optical signals from samples, comprising:
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a sample stage comprising a first interface and a second interface, the first interface comprising a platform for holding a sample on an open-faced support and for imaging of an external surface and the second interface comprising a platform for holding a sample in a flow cell for imaging of at least one internal surface, wherein the sample stage is configured to couple to the flow cell with fluidics connectors; an objective lens positioned proximate to the sample stage for imaging; an optical detector for detecting optical signals from the open-faced support and flow cell; and a moving mechanism for selectively moving one or more optical components into an optical pathway between the sample stage and the optical detector to either a first configuration for surface-imaging of the open-faced support or a second configuration for imaging the flow cell. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification