Radioimaging methods using teboroxime and thallium
First Claim
1. A method for imaging, comprising:
- administering a 99mTc-containing species to an adult human subject;
administering TI-201-thallous chloride to the subject;
performing a 99mTc-containing species SPECT imaging procedure of the 99mTc-containing species on a region of interest (ROI) of the subject; and
after administering the 99mTc-containing species, performing a TI-201-thallous chloride SPECT imaging procedure of the TI-201-thallous chloride on the ROI,wherein administering the 99mTc-containing species and the TI-201-thallous chloride and performing the 99mTc-containing species and the TI-201-thallous chloride SPECT imaging procedures comprise administering the 99mTc-containing species and the TI-201-thallous chloride and performing the 99mTc-containing species and the TI-201-thallous chloride SPECT imaging procedures during a time period having a duration of no more than 30 minutes, andwhere said 99mTc-containing species has the formula 99mTcX(Y)3Z, wherein;
X is an anion;
each Y, which is independently chosen, is a vicinal dioxime having the formula HON═
C(R1)C(R2)═
NOH or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are each independently hydrogen, halogen, alkyl, aryl, amino or a 5 or 6-membered nitrogen or oxygen containing heterocycle, or together R1 and R2 are —
(CR8CR9)n—
wherein n is 3, 4, 5 or 6 and R8 and R9 are each independently hydrogen or alkyl; and
Z is a boron derivative of the formula B—
R3 wherein R3 is hydroxy, alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkoxy, carboxyalkyl, carboxyalkenyl, hydroxyalkyl, hydroxyalkenyl, alkoxyalkyl, alkoxyalkenyl, haloalkyl, haloalkenyl, aryl, arylalkyl or (R4R5N)-alkyl and R4 and R5 are each independently hydrogen, alkyl, or arylalkyl, or R4 and R5 when taken together with the nitrogen atom to which they are attached form a 5 or 6-membered nitrogen containing heterocycle.
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Accused Products
Abstract
A method for imaging is providing, including administering a teboroxime species to an adult human subject, administering TI-201-thallous chloride to the subject, performing a teboroxime species SPECT imaging procedure of the teboroxime species on a region of interest (ROI) of the subject, and, after administering the teboroxime species, performing a TI-201-thallous chloride SPECT imaging procedure of the TI-201-thallous chloride on the ROI. Administering the teboroxime species and the TI-201-thallous chloride and performing the teboroxime species and the TI-201-thallous chloride SPECT imaging procedures comprise administering the teboroxime species and the TI-201-thallous chloride and performing the teboroxime species and the TI-201-thallous chloride SPECT imaging procedures during a time period having a duration of no more than 30 minutes. Other embodiments are also described.
762 Citations
71 Claims
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1. A method for imaging, comprising:
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administering a 99mTc-containing species to an adult human subject; administering TI-201-thallous chloride to the subject; performing a 99mTc-containing species SPECT imaging procedure of the 99mTc-containing species on a region of interest (ROI) of the subject; and after administering the 99mTc-containing species, performing a TI-201-thallous chloride SPECT imaging procedure of the TI-201-thallous chloride on the ROI, wherein administering the 99mTc-containing species and the TI-201-thallous chloride and performing the 99mTc-containing species and the TI-201-thallous chloride SPECT imaging procedures comprise administering the 99mTc-containing species and the TI-201-thallous chloride and performing the 99mTc-containing species and the TI-201-thallous chloride SPECT imaging procedures during a time period having a duration of no more than 30 minutes, and where said 99mTc-containing species has the formula 99mTcX(Y)3Z, wherein; X is an anion; each Y, which is independently chosen, is a vicinal dioxime having the formula HON═
C(R1)C(R2)═
NOH or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are each independently hydrogen, halogen, alkyl, aryl, amino or a 5 or 6-membered nitrogen or oxygen containing heterocycle, or together R1 and R2 are —
(CR8CR9)n—
wherein n is 3, 4, 5 or 6 and R8 and R9 are each independently hydrogen or alkyl; andZ is a boron derivative of the formula B—
R3wherein R3 is hydroxy, alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkoxy, carboxyalkyl, carboxyalkenyl, hydroxyalkyl, hydroxyalkenyl, alkoxyalkyl, alkoxyalkenyl, haloalkyl, haloalkenyl, aryl, arylalkyl or (R4R5N)-alkyl and R4 and R5 are each independently hydrogen, alkyl, or arylalkyl, or R4 and R5 when taken together with the nitrogen atom to which they are attached form a 5 or 6-membered nitrogen containing heterocycle. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A method for imaging, comprising:
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administering TI-201-thallous chloride to an adult human subject; after administering the TI-201-thallous chloride, administering a 99mTc-containing species to the subject; performing a 99mTc-containing species SPECT imaging procedure of the 99mTc-containing species on a region of interest (ROI) of the subject; and performing a TI-201-thallous chloride SPECT imaging procedure of the TI-201-thallous chloride on the ROI, wherein said 99mTc-containing species has the formula 99mTcX(Y)3Z, wherein; X is an anion; each Y, which is independently chosen, is a vicinal dioxime having the formula HON═
C(R1)C(R2)═
NOH or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are each independently hydrogen, halogen, alkyl, aryl, amino or a 5 or 6-membered nitrogen or oxygen containing heterocycle, or together R1 and R2 are —
(CR8CR9)n—
wherein n is 3, 4, 5 or 6 and R8 and R9 are each independently hydrogen or alkyl; andZ is a boron derivative of the formula B—
R3wherein R3 is hydroxy, alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkoxy, carboxyalkyl, carboxyalkenyl, hydroxyalkyl, hydroxyalkenyl, alkoxyalkyl, alkoxyalkenyl, haloalkyl, haloalkenyl, aryl, arylalkyl or (R4R5N)-alkyl and R4 and R5 are each independently hydrogen, alkyl, or arylalkyl, or R4 and R5 when taken together with the nitrogen atom to which they are attached form a 5 or 6-membered nitrogen containing heterocycle. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56)
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57. A method of imaging, comprising:
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administering a 99mTc-containing species to an adult human subject; administering TI-201-thallous chloride to the subject; and performing simultaneous SPECT imaging of the 99mTc-containing species and the TI-201-thallous chloride on a region of interest (ROI) of the subject, wherein said 99mTc-containing species has the formula 99mTcX(Y)3Z, wherein; X is an anion; each Y, which is independently chosen, is a vicinal dioxime having the formula HON═
C(R1)C(R2)═
NOH or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are each independently hydrogen, halogen, alkyl, aryl, amino or a 5 or 6-membered nitrogen or oxygen containing heterocycle, or together R1 and R2 are —
(CR8CR9)n—
wherein n is 3, 4, 5 or 6 and R8 and R9 are each independently hydrogen or alkyl; andZ is a boron derivative of the formula B—
R3wherein R3 is hydroxy, alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkoxy, carboxyalkyl, carboxyalkenyl, hydroxyalkyl, hydroxyalkenyl, alkoxyalkyl, alkoxyalkenyl, haloalkyl, haloalkenyl, aryl, arylalkyl or (R4R5N)-alkyl and R4 and R5 are each independently hydrogen, alkyl, or arylalkyl, or R4 and R5 when taken together with the nitrogen atom to which they are attached form a 5 or 6-membered nitrogen containing heterocycle. - View Dependent Claims (58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71)
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Specification