Liquid drug transfer assembly

• US 8,752,598 B2
• Filed: 04/17/2012
• Issued: 06/17/2014
• Est. Priority Date: 04/17/2011
• Status: Active Grant

• Current Assignee: West Pharma. Services IL, Ltd. (West Pharmaceutical Services Incorporated)
• Original Assignee: Medimop Medical Projects Ltd. (West Pharmaceutical Services Incorporated)
• Inventors: Denenburg, Igor, Lev, Nimrod, Bukhman, Mordechai
• Primary Examiner(s): NIESZ, JASON KAROL
• Application Number:
  US14/005,751
• Publication Number:
  US 20140020793A1
• Time in Patent Office: 791 Days
• Field of Search: 141/27, 141/100, 141/105, 141/319, 141/329, 141/330, 604/411, 604/412, 604/413, 604/414
• US Class Current: 141/329
• CPC Class Codes: A61J 1/201 having one piercing end
• CPC Class Codes: A61J 1/2013 having two piercing ends
• CPC Class Codes: A61J 1/2055 having gripping means
• CPC Class Codes: A61J 1/2065 having aligning and guiding means
• CPC Class Codes: A61J 1/2072 for internal venting
• CPC Class Codes: A61J 1/2086 for fluid filtration
• CPC Class Codes: A61J 1/2089 Containers or vials which are to be joined to each other in order to mix their contents combinations of vial and syringe for mixing their contents A61J1/2096
• CPC Class Codes: A61J 1/2096 Combination of a vial and a syringe for transferring or mixing their contents

Abstract

Liquid drug transfer assemblies for use with a drug vial having a drug vial opening stopped by a drug vial stopper. The liquid drug transfer assemblies include a drug vial stopper puncturing member for puncturing a drug vial stopper. The liquid drug transfer assemblies also include a drug vial adapter having a drug vial adapter skirt, an upright drug vial adapter port and a drug vial adapter sleeve downward depending opposite the upright drug vial adapter port and in flow communication therewith. The drug vial adapter is slidingly disposed on the drug vial stopper puncturing member such that on mounting the liquid drug transfer assembly on the drug vial, the drug vial stopper puncturing member punctures the drug vial stopper to form a throughgoing puncture bore and the drug vial adapter sleeve lines the puncture bore.

Claims

1. A liquid drug transfer assembly for use with a drug vial including a drug vial bottle containing a drug component and having a drug vial opening stopped by a drug vial stopper, the liquid drug transfer assembly comprising:

(a) a drug vial stopper puncturing member with a drug vial stopper puncturing tip for puncturing the drug vial stopper; and

(b) a drug vial adapter having a longitudinal drug vial adapter axis and including a drug vial adapter skirt having a transversely directed drug vial adapter top surface formed with an upright drug vial adapter port, a drug vial adapter body portion for snugly receiving the drug vial opening and a drug vial adapter skirt margin remote from said drug vial adapter top surface, and a drug vial adapter sleeve downward depending from said drug vial adapter top surface opposite said upright drug vial adapter port and in flow communication therewith,

said drug vial adapter being slidingly disposed on said drug vial stopper puncturing member such that said drug vial stopper puncturing tip protrudes beyond said drug vial adapter sleeve,

the arrangement being such that on mounting the liquid drug transfer assembly on the drug vial, said drug vial stopper puncturing member punctures the drug vial stopper to form a throughgoing puncture bore and said drug vial adapter sleeve lines said puncture bore whereby, on withdrawal of said drug vial stopper puncturing member from said puncture bore, said drug vial adapter sleeve prevents the drug vial stopper from sealing itself thereby enabling flow communication between said drug vial adapter port and the drug vial bottle.

2. The assembly according to claim 1, wherein said drug vial adapter skirt, said drug vial adapter port and said drug vial adapter sleeve are formed as a single injection plastic molded unit from the same plastic material.

3. The assembly according to claim 1, wherein said drug vial adapter sleeve is mounted on said drug vial adapter skirt and is formed from a different material therefrom.

4. The assembly according to claim 1, wherein said drug vial stopper puncturing member includes a liquid drug access port and a longitudinal lumen for enabling flow communication access to the drug vial bottle on said puncturing of the drug vial stopper.

5. The assembly according to claim 4, wherein drug vial stopper puncturing member includes an in-line filter.

6. The assembly according to claim 1, for additional use with a liquid vial including a liquid vial bottle containing a liquid component and having a liquid vial opening stopped by a liquid vial stopper, the liquid component intended for adding to the drug component to form liquid drug contents,

wherein said drug vial stopper puncturing member is formed as a dual ended dual lumen linear transfer spike integrally formed with a liquid vial adapter including a liquid vial adapter skirt having a transversely directed liquid vial adapter top surface and a liquid vial adapter body portion for snugly receiving the liquid vial opening therein,

said dual ended dual lumen linear transfer spike including a liquid vial stopper puncturing member opposite said drug vial stopper puncturing member, said liquid vial stopper puncturing member having a liquid vial stopper puncturing tip for puncturing the liquid vial stopper on mounting the liquid vial adapter on the liquid vial thereby enabling simultaneous gravitational flow of liquid component from the liquid vial to the drug vial and air flow from the drug vial to the liquid vial on forming an upright assemblage of an uppermost liquid vial and a lowermost drug vial for forming liquid drug contents in the drug vial for administration purposes on removal of the liquid vial adapter from the drug vial adapter.

7. The assembly according to claim 1, for additional use with a liquid vial including a liquid vial bottle containing a liquid component and having a liquid vial opening stopped by a liquid vial stopper, the liquid component intended for adding to the drug component to form liquid drug contents, said

wherein said drug vial stopper puncturing member is formed as one end of a dual ended dual lumen linear transfer spike having a longitudinal axis and including

i) an opposite directed liquid vial stopper puncturing member with a liquid vial stopper puncturing tip for puncturing the liquid vial stopper,

ii) a transverse directed spacing collar rigidly mounted on said linear transfer spike,

iii) at least two longitudinal directed drug vial legs mounted on said spacing collar and extending co-directional with and spaced apart from said drug vial stopper puncturing member,

said at least two drug vial legs terminating at drug vial leg tips co-extensive with and inwardly protruding toward said drug vial stopper puncturing tip,

iv) at least two longitudinal directed liquid vial legs mounted on said spacing collar and extending co-directional with and spaced apart from said liquid vial stopper puncturing member,

said at least two liquid vial legs terminating at liquid vial leg tips co-extensive with and inwardly protruding toward said liquid vial stopper puncturing tip,

said drug vial adapter being slidingly mounted on said drug vial stopper puncturing member with said drug vial adapter top surface towards said spacing collar and said drug vial adapter skirt margin remote therefrom,

said drug vial adapter skirt having drug vial leg tip apertures for initially receiving said drug vial leg tips for initially spacing said drug vial adapter from said spacing collar such that said drug vial adapter skirt margin is further from said spacing collar than said drug vial puncturing tip whereby, on sliding said drug vial adapter towards said spacing collar, said drug vial adapter skirt mounts on the drug vial opening for enclosing the drug vial opening in said drug vial adapter body portion, said drug vial stopper puncturing member punctures the drug vial stopper for flow communication with the drug vial bottle and said drug vial leg tips slide along said drug vial adapter skirt towards said drug vial adapter skirt margin;

and

(c) a liquid vial adapter including a liquid vial skirt adapter having a transversely directed liquid vial adapter top surface formed with a liquid vial adapter body portion for snugly receiving the liquid vial opening and a liquid vial adapter skirt margin,

said liquid vial adapter being slidingly disposed on said liquid vial stopper puncturing member with said liquid vial adapter top surface towards said spacing collar and said liquid vial adapter skirt margin remote therefrom,

said liquid vial adapter skirt having liquid vial leg tip apertures for initially receiving said liquid vial leg tips for initially spacing said liquid vial adapter from said spacing collar such that said liquid vial adapter skirt margin is further from said spacing collar than said liquid vial stopper puncturing tip whereby, on sliding said liquid vial adapter towards said spacing collar, said liquid vial adapter skirt mounts on the liquid vial opening for enclosing the liquid vial opening in said liquid vial adapter body portion, said liquid vial stopper puncturing member punctures the liquid vial stopper for flow communication with the liquid vial bottle and said liquid vial leg tips slide along said liquid vial adapter skirt towards said liquid vial adapter skirt margin.

8. The assembly according to claim 7, wherein said liquid drug transfer device and said liquid vial adapter have a snap fit arrangement for mechanically attaching said liquid drug transfer device to said liquid vial adapter on mounting said liquid vial adapter on the liquid vial.

9. The assembly according to claim 8, wherein said snap fit arrangement is constituted by said liquid vial adapter port having a longitudinal directed tubular member directed towards said spacing collar and said spacing collar having at least one snap member for snap fitting on said tubular member.

10. The assembly according to claim 7, wherein said drug vial adapter skirt margin is outwardly flared with respect to said drug vial adapter body portion and includes smooth external surfaces for facilitating said sliding of said drug vial leg tips towards said drug vial adapter skirt margin.

11. The assembly according to claim 7, wherein said liquid vial adapter skirt margin is outwardly flared with respect to said liquid vial adapter body portion and includes smooth external surfaces for facilitating said sliding of said liquid vial leg tips towards said liquid vial adapter skirt margin.

12. The assembly according to claim 7, wherein the liquid drug transfer assembly is packaged in a blister pack and each liquid vial leg has at least one outwardly directed liquid leg vial protrusion for bearing against an internal surface of said blister pack.