Automatic devices for remote ischemic preconditioning
First Claim
1. A device for remote ischemic preconditioning, the device comprising:
- a cuff sized to retract about a limb of a subject,a controller connected to said cuff, said controller configured to inflate and deflate said cuff according to a remote ischemic preconditioning treatment protocol, said treatment protocol includes at least two sequentially performed treatment cycles, each of said treatment cycles comprising;
inflating said cuff to a cuff pressure at or above a limb occlusion pressure of the subject,maintaining said cuff pressure at or above said limb occlusion pressure for a period of at least about one minute, anddeflating said cuff for at least about one minute to restore blood flow in said limb, wherein during maintaining said cuff pressure at or above said limb occlusion pressure, said controller is further configured to vary said cuff pressure at least once after a predetermined period of time during at least one of said treatment cycles.
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Accused Products
Abstract
Single- or dual-bladder devices for remote ischemic preconditioning and blood pressure monitoring are disclosed along with various oscillometry-based and other methods for detecting systolic and diastolic blood pressure while the ischemic preconditioning treatment is in progress. The devices and methods of the invention provide for delivery of ischemic preconditioning at the lowest effective cuff pressure while closely monitoring patient'"'"'s hemodynamics. Advantageously, the device of the invention allows both ischemic preconditioning and blood pressure monitoring to be done on the same limb. Disposable battery-powered version of the device of the present invention is especially useful for emergency use with patients suffering from acute myocardial infarction, acute stroke, or acute trauma. Additional device configurations are described for use in a percutaneous intervention and vascular sealing settings.
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Citations
4 Claims
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1. A device for remote ischemic preconditioning, the device comprising:
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a cuff sized to retract about a limb of a subject, a controller connected to said cuff, said controller configured to inflate and deflate said cuff according to a remote ischemic preconditioning treatment protocol, said treatment protocol includes at least two sequentially performed treatment cycles, each of said treatment cycles comprising; inflating said cuff to a cuff pressure at or above a limb occlusion pressure of the subject, maintaining said cuff pressure at or above said limb occlusion pressure for a period of at least about one minute, and deflating said cuff for at least about one minute to restore blood flow in said limb, wherein during maintaining said cuff pressure at or above said limb occlusion pressure, said controller is further configured to vary said cuff pressure at least once after a predetermined period of time during at least one of said treatment cycles. - View Dependent Claims (2, 3, 4)
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Specification