Automatic devices for remote ischemic preconditioning

• US 8,753,283 B2
• Filed: 01/31/2012
• Issued: 06/17/2014
• Est. Priority Date: 06/23/2009
• Status: Active Grant

• Current Assignee: Infarct Reduction Technologies, Inc.
• Original Assignee: Infarct Reduction Technologies, Inc.
• Inventors: Leschinsky, Boris
• Primary Examiner(s): Natnithithadha, Navin
• Application Number:
  US13/362,039
• Publication Number:
  US 20120130419A1
• Time in Patent Office: 868 Days
• Field of Search: 600/481, 600/483, 600/485, 600490-504, 606201-203
• US Class Current: 600/490
• CPC Class Codes: A61B 17/12109 in a blood vessel
• CPC Class Codes: A61B 17/12136 Balloons
• CPC Class Codes: A61B 17/135 inflatable for measuring blood pressure A61B5/022; inflatable pressure pads A61F5/34
• CPC Class Codes: A61B 17/1355 Automated control means therefor
• CPC Class Codes: A61B 2017/00199 with a console, e.g. a control panel with a display
• CPC Class Codes: A61B 5/02208 using the Korotkoff method
• CPC Class Codes: A61B 5/02225 using the oscillometric method
• CPC Class Codes: A61B 5/02233 Occluders specially adapted therefor tourniquets A61B17/132
• CPC Class Codes: A61H 1/006 Apparatus for applying pressure or blows for compressive stressing of a part of the skeletal structure, e.g. for preventing or alleviating osteoporosis
• CPC Class Codes: A61H 2201/5035 Several programs selectable
• CPC Class Codes: A61H 2201/5038 freely programmable by the user
• CPC Class Codes: A61H 2201/5071 Pressure sensors
• CPC Class Codes: A61H 2230/30 Blood pressure A61H2230/04 takes precedence
• CPC Class Codes: A61H 9/0078 with intermittent or alternately inflated bladders or cuffs mattresses for preventing bed-sores with alternated pressurized chambers A61G7/05776
• CPC Class Codes: A61H 9/0092 Cuffs therefor

Abstract

Single- or dual-bladder devices for remote ischemic preconditioning and blood pressure monitoring are disclosed along with various oscillometry-based and other methods for detecting systolic and diastolic blood pressure while the ischemic preconditioning treatment is in progress. The devices and methods of the invention provide for delivery of ischemic preconditioning at the lowest effective cuff pressure while closely monitoring patient'"'"'s hemodynamics. Advantageously, the device of the invention allows both ischemic preconditioning and blood pressure monitoring to be done on the same limb. Disposable battery-powered version of the device of the present invention is especially useful for emergency use with patients suffering from acute myocardial infarction, acute stroke, or acute trauma. Additional device configurations are described for use in a percutaneous intervention and vascular sealing settings.

Claims

1. A device for remote ischemic preconditioning, the device comprising:

a cuff sized to retract about a limb of a subject,

a controller connected to said cuff, said controller configured to inflate and deflate said cuff according to a remote ischemic preconditioning treatment protocol, said treatment protocol includes at least two sequentially performed treatment cycles, each of said treatment cycles comprising;

inflating said cuff to a cuff pressure at or above a limb occlusion pressure of the subject,

maintaining said cuff pressure at or above said limb occlusion pressure for a period of at least about one minute, and

deflating said cuff for at least about one minute to restore blood flow in said limb, wherein during maintaining said cuff pressure at or above said limb occlusion pressure, said controller is further configured to vary said cuff pressure at least once after a predetermined period of time during at least one of said treatment cycles.

2. The device as in claim 1, wherein said controller is further configured to detect a systolic blood pressure of the subject during varying of said cuff pressure.

3. The device as in claim 2, wherein said controller is further configured to inflate said cuff pressure to a vicinity of a previously recorded systolic blood pressure during varying of said cuff pressure.

4. The device as in claim 3, wherein said controller is further configured to determine a diastolic pressure of the subject, whereby said subject is under continuous hemodynamic surveillance throughout said ischemic preconditioning treatment.