Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
First Claim
1. A non-porous film of an oriented poly-4-hydroxybutyrate polymer or a copolymer thereof,wherein the film has an elongation at break from 10-500%, andwherein the film is derived by drying the polymer or copolymer to less than 0.01% (w/w) water, melt extruding the polymer or copolymer, then orienting the film by stretching the film by more than 25% of the film'"'"'s original length in one or more directions.
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Accused Products
Abstract
Continuous processing methods for making absorbable polymeric films with one or more of the following properties: high toughness, low modulus, high tensile strength, and thickness less than 10 mm, more preferably less than 1 mm, and more preferably less than 100 μm, have been developed. In the preferred embodiment, the polymer is a polyhydroxyalkanoate, and in the most preferred embodiment, the polymer comprises 4-hydroxybutyrate. A particularly preferred embodiment is a film of poly-4-hydroxybutyrate or copolymer thereof, wherein the film has a tensile strength greater than 5.5 kgf/mm2, tensile modulus less than 181 kgf/mm2, and elongation at break from 10-500%, wherein the film is derived by a continuous process such as melt extrusion or solvent casting, followed by orientation to more than 25% of the film'"'"'s original length in one or more directions. These can be used for a variety of purposes including fabrication of medical devices.
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Citations
18 Claims
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1. A non-porous film of an oriented poly-4-hydroxybutyrate polymer or a copolymer thereof,
wherein the film has an elongation at break from 10-500%, and wherein the film is derived by drying the polymer or copolymer to less than 0.01% (w/w) water, melt extruding the polymer or copolymer, then orienting the film by stretching the film by more than 25% of the film'"'"'s original length in one or more directions.
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7. A method of producing a non-porous oriented poly-4-hydroxybutyrate polymer or copolymer film, wherein the film has an elongation at break from 10-500%,
comprising drying the polymer or copolymer to less than 0.01% (w/w) water, melt extruding the polymer or copolymer to form a film, and orienting the film by stretching the film by more than 25% of the film'"'"'s original length in one or more directions.
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9. A method of using a device comprising a non-porous oriented poly-4-hydroxybutyrate polymer or copolymer film,
wherein the film has an elongation at break from 10-500%, wherein the film is derived by a continuous process of solvent casting or melt extrusion of the polymer or copolymer to form a film, followed by orienting the film by stretching the film by more than 25% of the film'"'"'s original length in one or more directions, comprising inserting or implanting the device into an individual in need thereof.
Specification