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Methods and kits for the differential diagnosis of Alzheimer's disease versus frontotemporal dementia and for the diagnosis of frontotemporal dementia, comprising FAS-L and CK 18 as biomarkers

  • US 8,753,607 B2
  • Filed: 07/19/2011
  • Issued: 06/17/2014
  • Est. Priority Date: 03/21/2008
  • Status: Active Grant
First Claim
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1. A diagnostic kit for determining a differential diagnosis in a non-invasive manner in an individual of Alzheimer'"'"'s disease (AD) versus frontotemporal dementia (FTD) consisting of:

  • a) reagents specific for TNF-α

    , FAS-L, and caspase-cleaved CK18,b) instructions for use of the reagents to determine levels of said TNF-α

    , FAS-L, and caspase-cleaved CK18 in biological samples obtained from such individual,c) optionally, a reference substance for each of said TNF-α

    , FAS-L, and caspase-cleaved CK18 for normalizing data, andd) an information sheet for comparing measured levels of said TNF-α

    , FAS-L, and caspase-cleaved CK18 to reference levels for each of said TNF-α

    , FAS-L, and caspase-cleaved CK18 to determine whether said individual is suffering from AD or FTD, and/ore) an information sheet for comparing the levels of TNF-α

    , FAS-L and caspase-cleaved CK18 to reference levels for each of said TNF-α

    , FAS-L and caspase-cleaved CK18 relating to severity of AD or FTD to determine the severity of AD or FTD in said individual.

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