Punctal plugs and methods of delivering therapeutic agents
First Claim
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1. A drug-delivery device comprising:
- (a) a body comprising a matrix of a silicone and an ophthalmic drug dispersed throughout the matrix, the body being a monolithic structure having an outer surface and being configured to be inserted through a punctal aperture and positioned in a punctum or lacrimal canaliculus;
(b) a parylene coating covering the outer surface of the body, the parylene coating being substantially impermeable to the drug; and
(c) at least one pore in the parylene coating, wherein the at least one pore extends from an outer surface of the parylene coating to the surface of the body;
wherein the parylene coating covers all surfaces of the outer surface of the body with the exception of the surface of the body exposed by the at least one pore;
wherein the ophthalmic drug is a glaucoma medicament.
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Abstract
The present invention concerns implantable ocular devices for the sustained release of medication to the eye, and methods for manufacturing and using such devices. In one embodiment, the present invention provides a device comprising: (a) a body comprising a matrix of a prostaglandin and a silicone; (b) a parylene coating on the outer surface of the body; and (c) one or more pores extending from the outer surface of the parylene coating to the outer surface of the body.
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Citations
23 Claims
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1. A drug-delivery device comprising:
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(a) a body comprising a matrix of a silicone and an ophthalmic drug dispersed throughout the matrix, the body being a monolithic structure having an outer surface and being configured to be inserted through a punctal aperture and positioned in a punctum or lacrimal canaliculus; (b) a parylene coating covering the outer surface of the body, the parylene coating being substantially impermeable to the drug; and (c) at least one pore in the parylene coating, wherein the at least one pore extends from an outer surface of the parylene coating to the surface of the body; wherein the parylene coating covers all surfaces of the outer surface of the body with the exception of the surface of the body exposed by the at least one pore; wherein the ophthalmic drug is a glaucoma medicament. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 20, 21, 23)
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15. A drug-delivery device comprising:
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(a) a body comprising a matrix of a silicone and an ophthalmic drug dispersed throughout the matrix, the body having an outer surface and being configured to be inserted through a punctal aperture and positioned in a punctum or lacrimal canaliculus, wherein the body is a monolithic structure that includes; i. a shaft portion having a first end and a second end, wherein the shaft portion is configured for insertion through a punctal aperture and positioning in a punctum or lacrimal canaliculus; ii. a head portion attached to the first end of the shaft portion, wherein the head portion is configured to rest on the exterior of the punctum; and iii. a distal tip portion attached to the second end of the shaft portion; (b) a parylene coating covering the outer surface of the body, the parylene coating being substantially impermeable to the drug; and (c) at least one pore in the parylene coating, wherein the at least one pore extends from an outer surface of the parylene coating to the surface of the head portion of the body; wherein the parylene coating covers all surfaces of the outer surface of the body with the exception of the surface of the head portion exposed by the at least one pore; wherein the ophthalmic drug is a glaucoma medicament. - View Dependent Claims (16, 17, 18, 22)
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19. A drug-delivery device comprising:
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(a) a body comprising a matrix of a silicone and an ophthalmic drug dispersed throughout the matrix, the body having an outer surface and being configured to be inserted through a punctal aperture and positioned in a punctum or lacrimal canaliculus, wherein the body is a monolithic structure that includes; i. a shaft portion having a first end and a second end, wherein the shaft portion is configured for insertion through a punctal aperture and positioning in a punctum or lacrimal canaliculus; ii. a head portion attached to the first end of the shaft portion, wherein the head portion is configured to rest on the exterior of the punctum; and iii. a distal tip portion attached to the second end of the shaft portion; (b) a parylene coating covering the outer surface of the body, the parylene coating being substantially impermeable to the drug; and (c) at least one pore in the parylene coating, wherein the at least one pore extends from an outer surface of the parylene coating to the surface of the head portion of the body; wherein the parylene coating covers all surfaces of the outer surface of the body with the exception of the surface of the head portion exposed by the at least one pore and wherein the ophthalmic drug is travoprost and wherein the silicone operates in conjunction with the at least one pore to release the travoprost at a therapeutically effective dose for period of 60 to 240 days.
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Specification