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Ex vivo modifiable multiple medicament final dosage form

  • US 8,753,677 B2
  • Filed: 04/29/2009
  • Issued: 06/17/2014
  • Est. Priority Date: 09/16/2008
  • Status: Expired due to Fees
First Claim
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1. A final dosage form for administering medicament to an animal, the final dosage form comprises:

  • a dosage portion havinga medicament; and

    a release element in a first medicament-release state wherein the medicament has a first bioavailability to the animal,wherein, when the release element is exposed ex vivo to a particular stimulus, an alteration occurs in a structure of the release element switching the release element from the first medicament-release state to a second medicament-release state wherein the medicament has a second bioavailability to the animal;

    another dosage portion havinganother medicament; and

    another release element in another first medicament-release state wherein the another medicament has another first bioavailability to the animal,wherein, when the release element is exposed ex vivo to another particular stimulus, an alteration occurs in a structure of the another release element switching the release element from the another first medicament-release state to another second medicament-release state wherein the medicament has another second bioavailability to the animal;

    a capsule structure including an outer layer and enclosing the dosage portion and the another dosage portion;

    an electronically detectable indicator element including a material that polymerizes responsive to the particular stimulus to thereby indicate exposure to the particular stimulus, the responsive polymerization inducing a change in a conductive property of the electronically detectable indicator element, the electronically detectable indicator element at least partially embedded in the outer layer of the capsule structure; and

    another electronically detectable indicator element including a material that polymerizes responsive to the another particular stimulus to thereby indicate exposure to the another particular stimulus, the responsive polymerization inducing a change in a conductive property of the another electronically detectable indicator element, the another electronically detectable indicator element at least partially embedded in the outer layer of the capsule structure.

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