×

Biochip

  • US 8,753,874 B2
  • Filed: 12/15/2003
  • Issued: 06/17/2014
  • Est. Priority Date: 12/19/2002
  • Status: Active Grant
First Claim
Patent Images

1. A DNA chip, comprising:

  • a flat carrier;

    an array of spots containing catcher molecules, each spot being assigned a microelectrode arrangement for detecting binding events between the catcher molecules and target molecules applied via an analyte solution, wherein the microelectrode arrangement is at least a two-pole system,the microelectrode arrangement being at least partially embedded in a hydrophilic reaction layer which is permeable to target molecules and in which immobilized catcher molecules are distributed three-dimensionally, wherein the catcher molecules are configured to cause the binding events,the hydrophilic reaction layer having a thickness approximately in the range of 1L to 5 L, L being the sum of electrode width and electrode spacing, the electrode width and the electrode spacing being approximately 1 μ

    m,wherein the chip is configured for application of an alternating voltage in a megahertz frequency, andwherein the chip is configured to detect a capacitance change caused by the binding events within the hydrophilic reaction layer with a megahertz frequency applied to the electrodes.

View all claims
  • 2 Assignments
Timeline View
Assignment View
    ×
    ×