Treatment of psoriasis using placental stem cells

• US 8,753,883 B2
• Filed: 05/13/2011
• Issued: 06/17/2014
• Est. Priority Date: 02/13/2002
• Status: Active Grant

• Current Assignee: Celularity, Inc.
• Original Assignee: Anthrogenesis Corporation (Bristol-Myers Squibb Company)
• Inventors: Edinger, James W., Hariri, Robert J., Wang, Jia-Lun, Ye, Qian, Faleck, Herbert
• Primary Examiner(s): Schultz, Doug
• Application Number:
  US13/107,778
• Publication Number:
  US 20110280843A1
• Time in Patent Office: 1,131 Days
• Field of Search: None
• US Class Current: 435/366
• CPC Class Codes: A61K 2035/122 for inducing tolerance or supression of immune responses
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 35/50 Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
• CPC Class Codes: A61K 35/644 Beeswax; Propolis; Royal jelly; Honey
• CPC Class Codes: A61K 38/21 Interferons [IFN]
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 1/12 Antidiarrhoeals
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/02 for peripheral neuropathies
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 35/02 specific for leukemia
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 37/02 Immunomodulators
• CPC Class Codes: A61P 37/06 Immunosuppressants, e.g. drugs for graft rejection
• CPC Class Codes: A61P 9/14 Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
• CPC Class Codes: C12N 2500/25 Insulin-transferrin; Insulin-transferrin-selenium
• CPC Class Codes: C12N 2500/36 Lipids
• CPC Class Codes: C12N 2501/11 : Epidermal growth factor [EGF]
• CPC Class Codes: C12N 2501/135 : Platelet-derived growth factor [PDGF]
• CPC Class Codes: C12N 2501/39 : Steroid hormones
• CPC Class Codes: C12N 5/0605 : Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly

Abstract

Provided herein are methods of treatment of individuals having an immune-related disease, disorder or condition, for example, inflammatory bowel disease, graft-versus-host disease, multiple sclerosis, rheumatoid arthritis, psoriasis, lupus erythematosus, diabetes, mycosis fungoides (Alibert-Bazin syndrome), or scleroderma using placental stem cells or umbilical cord stem cells.

Claims

1. A method of treating an individual having or at risk of developing psoriasis, comprising administering to the individual a therapeutically effective amount of placental stem cells, wherein the therapeutically effective amount is an amount sufficient to cause a detectable improvement in one or more symptoms of said psoriasis;

and wherein said placental stem cells are CD34⁻

, CD10⁺, CD105⁺, and CD200⁺.

2. The method of claim 1, wherein said placental stem cells are additionally CD73⁺.

3. The method of claim 2, wherein said placental stem cells are additionally CD38⁻

and CD45⁻

.

4. The method of claim 3, wherein said placental stem cells are additionally HLA-G⁺.

5. The method of claim 1, wherein said placental stem cells are additionally OCT-4⁺.

6. The method of claim 5, wherein said placental stem cells are additionally CD73⁺.

7. The method of claim 6, wherein said placental stem cells are additionally CD38⁻

and CD45⁻

.