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Mice that make heavy chain antibodies

  • US 8,754,287 B2
  • Filed: 12/10/2010
  • Issued: 06/17/2014
  • Est. Priority Date: 12/10/2009
  • Status: Active Grant
First Claim
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1. A transgenic mouse comprising a germline modification, which modification comprises:

  • (a) a deletion of a nucleic acid sequence encoding a CH1 domain of an endogenous IgG constant region gene; and

    (b) an inclusion of one or more human heavy chain variable region gene segments, wherein the one or more human heavy chain variable region gene segments is operably linked to the endogenous IgG constant region of (a);

    wherein the mouse comprises an intact IgM constant region gene and wherein the mouse expresses an IgG heavy chain antibody comprising a human variable domain, lacking a CH1 domain, in whole or in part, and lacking a cognate light chain and secretes said IgG heavy chain antibody into its serum.

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