Apparatus and method for thermal assisted desorption ionization systems
First Claim
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1. A method of analyzing an analyte comprising:
- introducing the analyte onto one or more mesh positioned between a source and an entrance of a spectrometer;
directing a plurality of ionizing species formed by the source at the one or more mesh;
heating one or more of the one or more mesh, where analyte molecules desorbed from the one or more mesh interact with the ionizing species to form one or more analyte ions which pass through the entrance of the spectrometer and are analyzed.
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Abstract
The present invention is directed to a method and device to desorb an analyte using heat to allow desorption of the analyte molecules, where the desorbed analyte molecules are ionized with ambient temperature ionizing species. In various embodiments of the invention a current is passed through a mesh upon which the analyte molecules are present. The current heats the mesh and results in desorption of the analyte molecules which then interact with gas phase metastable neutral molecules or atoms to form analyte ions characteristic of the analyte molecules.
216 Citations
20 Claims
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1. A method of analyzing an analyte comprising:
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introducing the analyte onto one or more mesh positioned between a source and an entrance of a spectrometer; directing a plurality of ionizing species formed by the source at the one or more mesh; heating one or more of the one or more mesh, where analyte molecules desorbed from the one or more mesh interact with the ionizing species to form one or more analyte ions which pass through the entrance of the spectrometer and are analyzed. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of analyzing an analyte comprising:
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continuously introducing the analyte onto a mesh positioned between a source and an entrance of a spectrometer; directing a plurality of ionizing species formed by the source at the mesh; heating the mesh, where analyte molecules desorbed from the mesh interact with the ionizing species to form one or more analyte ions which pass through the entrance of the spectrometer and are analyzed. - View Dependent Claims (13, 14, 15, 16, 17)
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18. A method of analyzing an analyte comprising:
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introducing the analyte onto a first mesh with a first potential applied to the first mesh, where the first mesh is positioned between a source and an entrance of a spectrometer, where the first potential is approximately the same potential as a potential applied to the entrance of the spectrometer, where a second potential is applied to a second mesh, where the second mesh is positioned between the first mesh and the entrance of the spectrometer, where the second potential is different from the first potential; directing a plurality of ionizing species formed by the source at the first mesh; heating the first mesh, where analyte molecules desorbed from the first mesh interact with the ionizing species to form one or more analyte ions which pass through the entrance for the spectrometer and are analyzed, where the kinetic energy of the analyte ions desorbed from the first mesh can be adjusted by adjusting the second potential. - View Dependent Claims (19, 20)
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Specification