Teletherapy location and dose distribution control system and method

• US 8,755,489 B2
• Filed: 11/11/2011
• Issued: 06/17/2014
• Est. Priority Date: 11/11/2010
• Status: Active Grant

• Current Assignee: P-Cure Ltd.
• Original Assignee: P-Cure Ltd.
• Inventors: Lavi, Guy, Marash, Michael
• Primary Examiner(s): SONG, HOON K
• Application Number:
  US13/294,195
• Publication Number:
  US 20120123183A1
• Time in Patent Office: 949 Days
• Field of Search: 378/65, 378/207
• US Class Current: 378/65
• CPC Class Codes: A61N 5/103 Treatment planning systems
• CPC Class Codes: A61N 5/1037 taking into account the movement of the target, e.g. 4D-image based planning

Abstract

A method of adjusting an irradiation treatment plan, the plan constituted of: obtaining a plurality of reference scans of a target tissue over a breathing cycle; obtaining a pre-treatment scan of the target tissue; identifying the reference scan whose phase is consonant with the obtained pre-treatment scan; computing at least one motion vector field between the identified reference scan and another of the plurality of reference scans different from the identified reference scan; applying the at least one computed motion vector field to one of the obtained pre-treatment scan and the another of the plurality of reference scans so as to obtain at least one synthetic scan whose phase is consonant with the other of the obtained pre-treatment scan and the another of the plurality of reference scans; and adjusting one of an irradiation dose, irradiation angle and irradiation positioning responsive to the at least one synthetic scan.

Claims

1. A method of controlling irradiation positioning, the method comprising:

obtaining a plurality of reference scans of a target tissue, each representing a unique phase of a breathing cycle;

obtaining a pre-treatment scan of the target tissue;

identifying the reference scan of the obtained plurality of reference scans whose phase is consonant with the obtained pre-treatment scan;

computing at least one motion vector field between the identified reference scan and another of the plurality of reference scans different from the identified reference scan;

applying the at least one computed motion vector field to one of the obtained pre-treatment scan and the another of the plurality of reference scans so as to derive at least one synthetic scan whose phase is consonant with the other of the obtained pre-treatment scan and the another of the plurality of reference scans; and

positioning the target tissue in relation to a therapeutic agent source responsive to said obtained at least one synthetic scan.

2. The method of claim 1, further comprising:

identifying morphological changes to the target tissue responsive to a comparison of the derived at least one synthetic scan with the other of the obtained pre-treatment scan and the another of the plurality of reference scans; and

adjusting one of an irradiation dose, irradiation angle and irradiation positioning responsive to the identified morphological changes.

3. The method according to claim 2, wherein the at least one computed motion vector field comprises a plurality of motion vector fields, each of the plurality of motion vector fields associated with a particular one of the plurality of reference scans, and wherein a plurality of synthetic scans are derived by respectively applying each of the plurality of motion vector fields to one of the obtained pre-treatment scan and the respective one of the plurality of reference scans, and

wherein said identifying morphological changes to the target tissue is responsive to a comparison of each of the plurality of derived synthetic scans with the respective other of the obtained pre-treatment scan and the respective one of the plurality of reference scans, to thereby identify morphological changes over the breathing cycle.

4. The method according to claim 1, wherein the another of the plurality of reference scans is a treatment plan phase scan.

5. The method according to claim 1, wherein the at least one computed motion vector field comprises a plurality of motion vector fields, each of the plurality of motion vector fields associated with a particular one of the plurality of reference scans, and wherein a plurality of synthetic scans are derived by respectively applying each of the plurality of motion vector fields to one of the obtained pre-treatment scan and the respective one of the plurality of reference scans.

6. A teletherapy control system comprising:

a teletherapy management server;

a positioning apparatus responsive to said teletherapy management server; and

an imaging unit in communication with the teletherapy management server, said teletherapy management server arranged to;

obtain a plurality of reference scans of a target tissue, each representing a unique phase of a breathing cycle;

obtain a pre-treatment scan of the target tissue;

identify the reference scan of the obtained plurality of reference scans whose phase is consonant with the obtained pre-treatment scan;

compute at least one motion vector field between the identified reference scan and another of the plurality of reference scans different from the identified reference scan;

apply the computed at least one motion vector field to one of the obtained pre-treatment scan and the another of the plurality of reference scans so as to derive at least one synthetic scan whose phase is consonant with the other of the obtained pre-treatment scan and the another of the plurality of reference scans; and

control said positioning apparatus so as to position the target tissue in relation to a therapeutic agent source responsive to said derived at least one synthetic scan.

7. The teletherapy control system according to claim 6, further comprising a therapeutic agent source responsive to said teletherapy management server,

wherein said teletherapy management server is further arranged to:

identify morphological changes to the target tissue responsive to a comparison of the derived at least one synthetic scan with the other of the obtained pre-treatment scan and the another of the plurality of reference scans; and

adjust one of an irradiation dose of said therapeutic agent source, irradiation angle from said therapeutic agent source and irradiation positioning relative to said therapeutic agent source responsive to the identified morphological changes.

8. The teletherapy control system according to claim 7,

wherein the at least one computed motion vector field comprises a plurality of motion vector fields, each of the plurality of motion vector fields associated with a particular one of the plurality of reference scans, and wherein a plurality of synthetic scans are derived by respectively applying each of the plurality of motion vector fields to one of the obtained pre-treatment scan and the respective one of the plurality of reference scans, and

wherein said identification of morphological changes to the target tissue is responsive to a comparison of each of the plurality of derived synthetic scans with the respective other of the obtained pre-treatment scan and the respective one of the plurality of reference scans, to thereby identify morphological changes over the breathing cycle.

9. The teletherapy control system according to claim 6, wherein the another of the plurality of reference scans is a treatment plan phase scan.

10. The teletherapy control system according to claim 6, wherein the at least one computed motion vector field comprises a plurality of motion vector fields, each of the plurality of motion vector fields associated with a particular one of the plurality of reference scans, and wherein a plurality of synthetic scans are derived by respectively applying each of the plurality of motion vector fields to one of the obtained pre-treatment scan and the respective one of the plurality of reference scans.

11. A non-transitory computer readable medium containing instructions for controlling an electronic device to perform a method of adjusting an irradiation treatment plan responsive to morphological changes, the method comprising:

obtaining a plurality of reference scans of a target tissue each representing a unique phase of a breathing cycle;

obtaining a pre-treatment scan of the target tissue;

identifying the reference scan of the obtained plurality of reference scans whose phase is consonant with the obtained pre-treatment scan;

computing at least one motion vector field between the identified reference scan and another of the plurality of reference scans different from the identified reference scan;

applying the at least one computed motion vector field to one of the obtained pre-treatment scan and the another of the plurality of reference scans so as to derive at least one synthetic scan whose phase is consonant with the other of the obtained pre-treatment scan and the another of the plurality of reference scans; and

positioning the target tissue in relation to a therapeutic agent source responsive to said obtained at least one synthetic scan.

12. The non-transitory computer readable medium according to claim 11, the method further comprising:

identifying morphological changes to the target tissue responsive to a comparison of the obtained at least one synthetic scan with the other of the derived pre-treatment scan and the another of the plurality of reference scans; and

adjusting one of an irradiation dose, irradiation angle and irradiation positioning responsive to the identified morphological changes.

13. The non-transitory computer readable medium according to claim 12, wherein the at least one computed motion vector field comprises a plurality of motion vector fields, each of the plurality of motion vector fields associated with a particular one of the plurality of reference scans, and

wherein a plurality of synthetic scans are derived by respectively applying each of the plurality of motion vector fields to one of the obtained pre-treatment scan and the respective one of the plurality of reference scans, and

wherein said identifying morphological changes to the target tissue of the method is responsive to a comparison of each of the plurality of derived synthetic scans with the respective other of the obtained pre-treatment scan and the respective one of the plurality of reference scans, to thereby identify morphological changes over the breathing cycle.

14. The non-transitory computer readable medium according to claim 11, wherein the another of the plurality of reference scans is a treatment plan phase scan.

15. The non-transitory computer readable medium according to claim 11, wherein the at least one computed motion vector field comprises a plurality of motion vector fields, each of the plurality of motion vector fields associated with a particular one of the plurality of reference scans, and wherein a plurality of synthetic scans are derived by respectively applying each of the plurality of motion vector fields to one of the obtained pre-treatment scan and the respective one of the plurality of reference scans.