Intraocular iontophoretic device and associated methods
First Claim
1. A self-contained device for delivering an active agent into an eye of a subject, comprising:
- a device housing having a shape to conform to the surface of the eye;
a first electrode assembly located at least partially within the housing and having a first electrode and a reservoir configured to contain the active agent, said first electrode assembly being oriented within the housing to contact and remain against a surface of the eye during use;
a second electrode assembly located at least partially within the housing and having a second electrode, said second electrode assembly being oriented within the housing to contact and remain against a surface of the eye during use, wherein the first and second electrode assemblies are positioned within the housing to deliver electrical current transsclerally into the eye while limiting electrical current flow across the surface of the eye to thus complete an electrical circuit substantially within the eye; and
a power source located at least partially within the housing and electrically coupled to the first electrode and to the second electrode, wherein the first electrode and the second electrode are configured to be opposite in polarity to one another during iontophoretic delivery of an active agent into the eye.
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Accused Products
Abstract
The present invention includes methods and devices for delivering an active agent into the eye of a subject. One such device may include an anode assembly having an anode housing and an anode configured to electrically couple to a power source, the anode assembly being configured to contact and remain against a surface of the eye. The device may also include a cathode assembly having a cathode housing and a cathode configured to electrically couple to the power source, the cathode assembly being configured to contact and remain against the surface of the eye. Additionally, the device may include at least one active agent reservoir functionally associated with at least one of the anode assembly and the cathode assembly.
33 Citations
21 Claims
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1. A self-contained device for delivering an active agent into an eye of a subject, comprising:
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a device housing having a shape to conform to the surface of the eye; a first electrode assembly located at least partially within the housing and having a first electrode and a reservoir configured to contain the active agent, said first electrode assembly being oriented within the housing to contact and remain against a surface of the eye during use; a second electrode assembly located at least partially within the housing and having a second electrode, said second electrode assembly being oriented within the housing to contact and remain against a surface of the eye during use, wherein the first and second electrode assemblies are positioned within the housing to deliver electrical current transsclerally into the eye while limiting electrical current flow across the surface of the eye to thus complete an electrical circuit substantially within the eye; and a power source located at least partially within the housing and electrically coupled to the first electrode and to the second electrode, wherein the first electrode and the second electrode are configured to be opposite in polarity to one another during iontophoretic delivery of an active agent into the eye. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification