Systems for stimulating neural targets

• US 8,755,892 B2
• Filed: 05/16/2007
• Issued: 06/17/2014
• Est. Priority Date: 05/16/2007
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Amurthur, Badri, Libbus, Imad
• Primary Examiner(s): Schaetzle, Kennedy
• Assistant Examiner(s): LEE, ERICA SHENGKAI
• Application Number:
  US11/749,500
• Publication Number:
  US 20080288016A1
• Time in Patent Office: 2,589 Days
• Field of Search: 607/44, 607 55- 57, 607/136, 607/118, 607/137
• US Class Current: 607/44
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02405 Determining heart rate variability
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/4041 Evaluating nerves condition
• CPC Class Codes: A61B 5/6815 Ear
• CPC Class Codes: A61B 5/6826 Finger
• CPC Class Codes: A61B 5/6838 Clamps or clips
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61N 1/0452 Specially adapted for transcutaneous muscle stimulation [TMS]
• CPC Class Codes: A61N 1/0456 Specially adapted for transcutaneous electrical nerve stimulation [TENS]
• CPC Class Codes: A61N 1/0492 Patch electrodes A61N1/0412, A61N1/0428 take precedence
• CPC Class Codes: A61N 1/36017 with leads or electrodes penetrating the skin
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36117 for treating hypertension

Abstract

Disclosed herein, among other things, is a method for stimulating neural targets in the vicinity of a human ear. According to an embodiment, a device is clipped on a patient ear lobe, the device including a neural stimulation electrode. A neural stimulation signal is applied to the electrode to transcutaneously stimulate neural targets in the vicinity of the ear lobe, according to an embodiment. A physiological parameter is sensed using a sensor connected to the device. According to an embodiment, the neural stimulation signal is adjusted in response to the sensed parameter. The method is used is a variety of treatment regimens, including anti-hypertensive and cardiac improvement therapy.

Claims

1. A device for mounting to an ear lobe of a patient, the device comprising:

a clip configured to be clipped to the ear lobe;

a neural stimulator connected to the clip and including;

a neural stimulation circuit;

a controller;

a memory; and

an electrode; and

a sensor connected to the stimulation circuit, the sensor adapted to monitor a physiological parameter,

wherein the controller is configured to control the neural stimulation circuit to stimulate neural targets in the vicinity of the ear lobe, including setting parameters of a neural stimulation signal, and further configured to titrate therapy using the physiological parameter, and

wherein the clip, neural stimulator and sensor are configured such that the entire weight of the device is supported by the clip on the ear lobe.

2. The device of claim 1, wherein the sensor includes a blood pressure sensor adapted to sense a parameter indicative of blood pressure, wherein the neural stimulation signal is adapted to chronically lower blood pressure using the sensed parameter.

3. The device of claim 1, wherein the neural stimulator delivers stimulation therapy using a preprogrammed schedule to chronically lower blood pressure.

4. The device of claim 1, wherein the sensor includes a cardiac function sensor adapted to sense a parameter indicative of cardiac function, wherein the neural stimulation signal is adapted to improve cardiac function using the sensed parameter.

5. The device of claim 4, wherein the parameter indicative of cardiac function includes blood pressure.

6. The device of claim 4, wherein the parameter indicative of cardiac function includes heart rate.

7. The device of claim 4, wherein the parameter indicative of cardiac function includes heart rate variability (HRV).

8. The device of claim 1, wherein the neural stimulator delivers stimulation therapy using a preprogrammed schedule to improve cardiac function.

9. The device of claim 1, further comprising a communication circuit adapted to communicate with an implantable device.

10. The device of claim 1, wherein the sensor includes an infrared sensor.

11. A device for mounting to an ear lobe of a patient, the device comprising:

a clip configured to be clipped to the ear lobe;

a neural stimulator including an electrode in the clip, the neural stimulator adapted to stimulate neural targets in the vicinity of the ear lobe, the stimulator further adapted to communicate with a stimulation circuit to receive a neural stimulation signal;

a memory adapted to store a programmed schedule for delivering neural stimulation; and

a sensor connected to the stimulation circuit, the sensor adapted to monitor a physiological parameter,

wherein the device titrates therapy using the physiological parameter, and

wherein the clip, neural stimulator and sensor are configured such that the entire weight of the device is supported by the clip on the ear lobe.

12. The device of claim 11, wherein the memory includes computer-readable instructions that are capable of being operated on by a controller to perform functions of the device.

13. The device of claim 11, wherein the sensor includes a pulse oximetry sensor.

14. The device of claim 11, wherein the neural stimulator is adapted to stimulate an auricular branch of a vagal nerve.

15. The device of claim 11, wherein the sensor includes an acoustic sensor adapted to sense blood flow in a carotid artery.

16. A device for mounting to an ear lobe of a patient, the device comprising:

a housing, wherein the housing is conductive and functions as an electrode;

a clip configured to be clipped to the ear lobe;

a neural stimulator within the housing connected to the clip, the neural stimulator connected to the electrode and adapted to stimulate neural targets in the vicinity of the ear lobe;

a stimulation circuit within the housing adapted to communicate with the neural stimulator to provide a neural stimulation signal; and

a sensor connected to the stimulation circuit, the sensor adapted to monitor a physiological parameter,

wherein the device titrates therapy using the physiological parameter, and

wherein the clip, neural stimulator and sensor are configured such that the entire weight of the device is supported by the clip on the ear lobe.

17. The device of claim 16, wherein the neural stimulator includes a transceiver.

18. The device of claim 17, wherein die transceiver includes a wireless transceiver.

19. The device of claim 16, wherein the neural stimulator includes an actuator.

20. The device of claim 19, wherein the actuator is adapted to be used to initiate a programmed therapy.