Device for actively removing a target cell from blood or lymph of a vertebrate subject

• US 8,758,330 B2
• Filed: 04/13/2012
• Issued: 06/24/2014
• Est. Priority Date: 03/05/2010
• Status: Expired due to Fees

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Hyde, Roderick A., Ishikawa, Muriel Y., Jung, Edward K. Y., Langer, Robert, Leuthardt, Eric C., Myhrvold, Nathan P., Sweeney, Elizabeth A., Wood, Lowell L. Jr.
• Primary Examiner(s): Desanto, Matthew F
• Application Number:
  US13/446,253
• Publication Number:
  US 20120238948A1
• Time in Patent Office: 802 Days
• Field of Search: 6048901-8921, 604 65- 67, 604/4.01, 604/27, 604/28, 600/309, 600/439, 424/422, 424/140.1
• US Class Current: 604/891.1
• CPC Class Codes: A61B 5/6861 Capsules, e.g. for swallowing or implanting
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2002/068 Modifying the blood flow model, e.g. by diffuser or deflector
• CPC Class Codes: A61F 2250/0096 Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
• CPC Class Codes: A61M 1/3679 by absorption A61M1/3675 takes precedence
• CPC Class Codes: A61M 2205/04 implanted
• CPC Class Codes: A61M 2230/20 Blood composition characteristics
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04

Abstract

Devices, systems, and methods are described herein for controlling the level of one or more target cell types in the blood fluid and/or lymph fluid of a vertebrate subject. Devices and systems are provided that include a body defining at least one lumen configured for fluid flow; at least one controllable flow barrier to the at least one lumen; one or more sensor configured to detect one or more target cell types in blood fluid or lymph fluid of a vertebrate subject; at least one treatment region disposed within the at least one lumen; at least one reactive component disposed in the at least one treatment region; and at least one controller in communication with the one or more sensor and in communication with the at least one controllable flow barrier to the at least one lumen.

Claims

1. A system comprising:

an implantable device comprising a body defining at least one lumen configured for fluid flow;

at least one controllable flow barrier to the at least one lumen;

one or more sensor configured to detect one or more target cell types in blood fluid or lymph fluid of a vertebrate subject;

at least one treatment region disposed within the at least one lumen;

at least one reactive component disposed in the at least one treatment region, the at least one reactive component configured to modulate the physiological effect of the one or more target cell types in the vertebrate subject; and

at least one controller in communication with the one or more sensor and in communication with the at least one controllable flow barrier to the at least one lumen;

wherein the at least one controller is configured to open or close the at least one controllable flow barrier in response to the one or more sensor.

2. The system of claim 1, wherein the one or more reactive components include one or more of a cell-disrupting agent, a binding agent, or an energy source.

3. The system of claim 1, wherein the cell-disrupting agent includes a denaturing agent or a degradative agent.

4. The system of claim 2, wherein the binding agents include one or more of an adhesion molecule, antibody, binding mimetic, polymer, lectin, integrin, or selectin.

5. The system of claim 2, wherein the binding agents include one or more of antibodies, receptors, or cognates configured to bind to at least one of the one or more target cell types.

6. The system of claim 2, wherein the binding agent includes one or more of a specific binding ligand or a hydrophobic surface.

7. The system of claim 1, wherein the treatment region includes a source for producing the one or more reactive components.

8. The system of claim 7, wherein the source includes at least one encapsulated cell.

9. The system of claim 8, wherein the at least one encapsulated cell produces the one or more reactive components.

10. The system of claim 7, wherein the source includes at least one reservoir and at least one producer.

11. The system of claim 1, wherein the device is intracorporeal.

12. The system of claim 11, wherein the device is configured to be implanted relative to an organ or tissue in the vertebrate subject.

13. The system of claim 11, wherein the device is configured to be mobile relative to an organ or tissue in the vertebrate subject.

14. The system of claim 1, wherein the at least one treatment region including one or more reactive components is configured to receive the one or more target cell types, and the one or more reactive components are configured to bind to the one or more target cell types at a surface of the at least one treatment region.

15. The system of claim 14, wherein the at least one treatment region includes a matrix configured to present the one or more reactive components.

16. The system of claim 1, wherein the one or more reactive components is configured to alter, arrest, or destroy the one or more target cell types.

17. The system of claim 16, wherein the one or more reactive components is configured to produce necrosis or programmed cell death in the one or more target cell types.

18. The system of claim 1, wherein the at least one controller is configured to control release of the one or more reactive components.

19. The system of claim 18, wherein the deviation is determined by a weighted least squares fit.

20. The system of claim 1, wherein the one or more sensor includes a biosensor, chemical sensor, physical sensor, or optical sensor.

21. The system of claim 20, wherein the one or more sensor includes one or more of target recognition elements.

22. The system of claim 1, wherein the one or more reactive components include a cytotoxic agent, a cytostatic agent, a programmed cell death-inducing agent, a chemotherapeutic agent, or an antibody-toxin agent.

23. The system of claim 1, wherein the controller is configured to control interaction between the one or more reactive components and the one or more target cell types.

24. The system of claim 1, further including one or more reservoirs responsive to the controller, wherein the one or more reservoirs is configured to provide the one or more reactive components, and the one or more reservoirs is configured to function in, or proximal to, one or more of a blood vessel or a lymph vessel of the vertebrate subject.

25. The system of claim 1, further comprising:

a system including a signal-bearing medium including

one or more instructions for treatment of a vertebrate subject through a device including one or more instructions for receiving data including data from the at least one controllable flow barrier to the at least one lumen;

one or more instructions for receiving data including data from the one or more sensor configured to detect the one or more target cell types in the blood fluid or lymph fluid of the vertebrate subject;

one or more instructions for receiving data including data from the at least one treatment region disposed within the at least one lumen;

one or more instructions for receiving data including data from the at least one reactive component disposed in the at least one treatment region, the at least one reactive component configured to modulate the physiological effect of the one or more target cell types in the vertebrate subject; and

one or more instructions for receiving data including data from the at least one controller in communication with the one or more sensor and in communication with the at least one controllable flow barrier to the at least one lumen;

wherein the at least one controller is configured to open or close the at least one controllable flow barrier in response to the one or more sensor.

26. The system of claim 1, further comprising:

at least one computer program included on a computer-readable recordable-type medium for use with at least one computer system wherein the computer program includes,

one or more instructions for treatment of a vertebrate subject through a device including one or more instructions for receiving data including data from the at least one controllable flow barrier to the at least one lumen;

one or more instructions for receiving data including data from the one or more sensor configured to detect the one or more target cell types in the blood fluid or lymph fluid of the vertebrate subject;

one or more instructions for receiving data including data from the at least one treatment region disposed within the at least one lumen;

one or more instructions for receiving data including data from the at least one reactive component disposed in the at least one treatment region, the at least one reactive component configured to modulate the physiological effect of the one or more target cell types in the vertebrate subject; and

one or more instructions for receiving data including data from the at least one controller in communication with the one or more sensor and in communication with the at least one controllable flow barrier to the at least one lumen;

wherein the at least one controller is configured to open or close the at least one controllable flow barrier in response to the one or more sensor.

27. The system of claim 1, wherein the at least one treatment region is configured to be placed relative to a tumor or an organ in the vertebrate subject.

28. The system of claim 1, wherein the at least one lumen is configured for fluid flow including the one or more target cell types.

29. The system of claim 1, wherein the one or more sensor is configured to detect the one or more target cell types within the at least one lumen.

30. The system of claim 1, wherein the one or more sensor is configured to detect the one or more target cell types in the at least one treatment region.

31. The system of claim 1, wherein the one or more sensor is configured to detect the one or more target cell types after the one or more target cell types has passed through the at least one lumen or the at least one treatment region.

32. The system of claim 1, wherein the at least one controller is configured to return flow from the at least one lumen to a blood vessel or a lymph vessel.

33. The system of claim 1, wherein the at least one lumen is configured for extended residence time of the blood fluid or the lymph fluid.

34. The system of claim 1, wherein the one or more sensor is external to the at least one lumen.

35. The system of claim 1, wherein the one or more sensor is internal to the at least one lumen.

36. The system of claim 1, comprising at least one transmitter to report to the one or more sensor.

37. The system of claim 1, wherein the sensor is configured to report to an outside source or to a computing device.

38. The system of claim 1, wherein the at least one controller includes a processor.

39. The system of claim 1, wherein the one or more sensor is configured to function in, or proximal to, one or more of a blood vessel or a lymph vessel of the vertebrate subject.

40. The system of claim 1, wherein the at least one controller is configured to open or close the at least one controllable flow barrier in response to the one or more sensor to achieve a target level of the one or more target cell types in the vertebrate subject.

41. The system of claim 1, wherein the target level includes a desired concentration of the one or more target cell types in the one or more of the blood fluid or lymph fluid.

42. The system of claim 1, wherein the target level includes a desired range of concentrations of the one or more target cell types in the one or more of the blood fluid or lymph fluid.

43. The system of claim 1, wherein the target level includes a desired ratio of concentrations of two or more target cell types in the one or more of the blood fluid or lymph fluid.

44. The system of claim 1, wherein the target level includes a desired ratio of levels of two or more target cell types in the one or more of the blood fluid or lymph fluid.

45. The system of claim 1, wherein the one or more sensor and the at least one controller are configured to control levels of the detected one or more target cell types to limit a deviation from the target level.

46. The system of claim 1, wherein the sensor is configured to target the device to a site having an elevated level of the target cell types.

47. The system of claim 1, wherein the sensor is configured to report to an outside source or to a computing device, and wherein the sensor is configured to report a level of the one or more target cell types.

48. The system of claim 1, wherein the treatment region includes one or more reservoirs including the one or more reactive components.