Method for connecting nerves via a side-to-side epineurial window using artificial conduits

• US 8,758,374 B2
• Filed: 09/15/2011
• Issued: 06/24/2014
• Est. Priority Date: 09/15/2010
• Status: Active Grant

• Current Assignee: University of Utah Research Foundation (State of Utah)
• Original Assignee: University of Utah Research Foundation (State of Utah)
• Inventors: Agarwal, Jayant P.
• Primary Examiner(s): Isabella, David
• Assistant Examiner(s): Sharma, Yashita
• Application Number:
  US13/200,028
• Publication Number:
  US 20120065740A1
• Time in Patent Office: 1,013 Days
• Field of Search: 623/23.64, 623/23.65, 623/23.71, 623/23.72, 606151-156
• US Class Current: 606/152
• CPC Class Codes: A61B 17/1128 of nerves
• CPC Class Codes: A61B 2017/1139 Side-to-side connections, e.g. shunt or X-connections

Abstract

The disclosure provides methods for repairing nerves and inhibiting atrophy of a muscle via a side-to side neurorraphy using a bridging element between a first epineurial window on a donor nerve and a second epineurial window on a recipient nerve.

Claims

1. A method for repairing an at least partially transected nerve, the method comprising

providing a donor nerve and a recipient nerve, wherein the recipient nerve is at least partially transected at a proximal site;

creating a first epineurial window in a side of the donor nerve and a second epineurial window in a side of the recipient nerve at a site distal from the proximal site;

arranging the donor nerve and the recipient nerve in a side-by-side fashion with the first and second epineurial windows proximate to one another;

positioning between the first and second epineurial windows a bridging element having first and second ends and defining a conduit; and

connecting the first end of the bridging element to the first epineurial window and the second end of the bridging element to the second epineurial window such that the first and second epineurial windows are in fluid communication with each other via the conduit to permit transmission of signals from the donor nerve to the recipient nerve.

2. The method of claim 1, wherein the bridging element comprises an autologous biological tissue.

3. The method of claim 2, wherein the autologous biological tissue includes a non-nerve graft.

4. The method of claim 1, wherein the bridging element comprises a non-autologous biological tissue.

5. The method of claim 4, wherein the non-autologous biological tissue includes at least one of an allogenic tissue or a xenogenic tissue.

6. The method of claim 1, wherein the bridging element comprises a biologically derived material.

7. The method of claim 6, wherein the biologically derived material includes at least one of a fibrous protein, a polysaccharide, and a glycoprotein.

8. The method of claim 6, wherein the biologically derived material includes at least one of collagen, fibrin, extracellular matrix solution, fibronectin, alginate, gelatin, keratin, thrombin and silk.

9. The method of claim 1, wherein the bridging element comprises a synthetic material.

10. The method of claim 9, wherein the synthetic material comprises at least one of silicon, an aliphatic polyester, a poly(phosphoester), a hydrogel, and a poly(acrylonitrile-co-methylacrylate).

11. The method of claim 10, wherein the aliphatic polyester comprises at least one of poly-glycolic acid, poly-(lactic acid), poly-caprolactone, poly-(lactide-coglycolide) copolymer, poly-(L-lactic acid) and poly(3-hydroxybutyric acid).

12. The method of claim 10, wherein the poly(phosphoester) is at least one of poly((bis(hydroxyethy)terephthalate-ethyl phosphoester/terephthaloyl chloride) and polytetrafluoroethylene.

13. The method of claim 10, wherein the hydrogel comprises at least one of poly(2-hydroxyethyl methacrylate) (PHEMA) and a co-polymer of PHEMA and methyl methacrylate.

14. The method of claim 1, wherein upon connecting the first end of the bridging element to the first epineurial window and the second end of the bridging element to the second epineurial window, chemical signals traverse the bridging element via the conduit.

15. The method of claim 14, wherein the chemical signals are growth factors.

16. The method of claim 1, wherein the at least partially transected nerve is completely transected.

17. The method of claim 1, wherein none of the axons in the donor nerve are injured.

18. A method for at least partially inhibiting atrophy of a muscle that has ceased receiving signals from a nerve that has been severed, the method comprising:

creating a first epineurial window in a side of a healthy donor nerve and a second epineurial window in a side of a recipient nerve, wherein the recipient nerve has been severed proximal the epineurial window;

positioning the first and second epineurial windows of the donor nerve and the recipient nerve in a side-by-side fashion with a gap therebetween;

positioning between the first and second epineurial windows a bridging element having first and second ends and defining a conduit; and

connecting the first end of the bridging element to the first epineurial window and the second end of the bridging element to the second epineurial window while maintaining the gap between the first and second epineurial windows such that the first and second epineurial windows are in fluid communication with each other via the conduit, and the bridging element permits transmission of signals from the donor nerve to the muscle via the recipient nerve, thereby at least partially inhibiting atrophy of the muscle.

19. A method for repairing peripheral nerve injuries, the method comprising

performing a side-to-side neurorraphy using a bridging element between a first epineurial window on a donor nerve and a second epineurial window on a recipient nerve,

wherein the bridging element comprises first and second ends and defining a tubular conduit between the first and second ends, and

wherein the bridging element bridges and maintains a gap between the first and second epineurial windows such that the first and second epineurial windows are in fluid communication with each other via the tubular conduit to permit transmission of signals from the donor nerve to the recipient nerve.