Device and methods for coupling/uncoupling a target or an object present in a sample
First Claim
1. A device comprising:
- a support comprising a surface comprising an attachment zone (Z) functionalized with a probe (A) capable of binding to a target (B) so as to attach it;
a working electrode (WE) and a counterelectrode (CE) for the working electrode, placed on the support in the vicinity of the attachment zone, wherein the working electrode surrounds the attachment zone;
an empty space separating said attachment zone and said working electrode; and
a means for applying a given electric current or a given potential to said working electrode so as to cause, when said attachment zone and said electrodes are immersed in an aqueous solution, a local variation in pH in the region of said attachment zone.
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Abstract
The device of the invention comprises a support having a surface comprising an attachment zone (Z) capable of being functionalized with a probe (A) capable of binding, according to the pH and reversibly, to a target (B) so as to attach it; a working electrode (WE) and a counterelectrode (CE) for this working electrode, arranged on the support in the vicinity of the attachment zone; and means for applying a given electric current or a given potential to said working electrode so as to cause, when said attachment zone and said electrodes are immersed in an aqueous solution, a local variation in pH in the region of said attachment zone.
The method for attaching and/or detaching a target or an object according to the invention uses this device, the attachment and/or the detachment being electrochemically controlled with the working electrode.
13 Citations
13 Claims
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1. A device comprising:
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a support comprising a surface comprising an attachment zone (Z) functionalized with a probe (A) capable of binding to a target (B) so as to attach it; a working electrode (WE) and a counterelectrode (CE) for the working electrode, placed on the support in the vicinity of the attachment zone, wherein the working electrode surrounds the attachment zone; an empty space separating said attachment zone and said working electrode; and a means for applying a given electric current or a given potential to said working electrode so as to cause, when said attachment zone and said electrodes are immersed in an aqueous solution, a local variation in pH in the region of said attachment zone. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification