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Peptide-peptidase inhibitor conjugates and methods of using same

  • US 8,759,295 B2
  • Filed: 05/21/2010
  • Issued: 06/24/2014
  • Est. Priority Date: 03/21/2006
  • Status: Expired due to Fees
First Claim
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1. A peptide-peptidase inhibitor conjugate comprising a peptide covalently linked to a peptidase inhibitor, wherein the peptide comprises exendin-3, exendin-4, or an exendin analog comprising the sequence set forth in any one of SEQ ID NOs:

  • 65-71 and 73, wherein the peptidase inhibitor comprises an angiotensin-converting enzyme inhibitor, and wherein the peptide-peptidase inhibitor conjugate is synthesized chemically or recombinantly.

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