Peptide-peptidase inhibitor conjugates and methods of using same
First Claim
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1. A peptide-peptidase inhibitor conjugate comprising a peptide covalently linked to a peptidase inhibitor, wherein the peptide comprises exendin-3, exendin-4, or an exendin analog comprising the sequence set forth in any one of SEQ ID NOs:
- 65-71 and 73, wherein the peptidase inhibitor comprises an angiotensin-converting enzyme inhibitor, and wherein the peptide-peptidase inhibitor conjugate is synthesized chemically or recombinantly.
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Abstract
Peptide-peptidase inhibitor conjugate molecules are disclosed. These conjugate molecules are useful as agents for the treatment and prevention of metabolic and cardiovascular diseases, disorders, and conditions. Such diseases, conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, and other diabetes-related disorders.
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6 Claims
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1. A peptide-peptidase inhibitor conjugate comprising a peptide covalently linked to a peptidase inhibitor, wherein the peptide comprises exendin-3, exendin-4, or an exendin analog comprising the sequence set forth in any one of SEQ ID NOs:
- 65-71 and 73, wherein the peptidase inhibitor comprises an angiotensin-converting enzyme inhibitor, and wherein the peptide-peptidase inhibitor conjugate is synthesized chemically or recombinantly.
- View Dependent Claims (2, 3, 4, 5, 6)
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