Compounds and methods for the prevention and treatment of cancer

• US 8,759,367 B2
• Filed: 10/04/2011
• Issued: 06/24/2014
• Est. Priority Date: 10/20/2010
• Status: Active Grant

• Current Assignee: Trustees Of The University Of Pennsylvania (University of Pennsylvania)
• Original Assignee: The Wistar Institute, Trustees Of The University Of Pennsylvania (University of Pennsylvania)
• Inventors: Dahmane, Nadia, Winkler, Jeffrey D., Isaacs, Andre
• Primary Examiner(s): Andres, Janet L
• Assistant Examiner(s): Rozof, Timothy R
• Application Number:
  US13/880,223
• Publication Number:
  US 20130203794A1
• Time in Patent Office: 994 Days
• Field of Search: None
• US Class Current: 514/278
• CPC Class Codes: C07D 471/10 Spiro-condensed systems
• CPC Class Codes: C07D 491/107 with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Abstract

The present invention relates to compounds for modulating sonic hedgehog signaling and preventing or treating cancer.

Claims

1. A compound having the structure:

2. The compound of claim 1, wherein said compound is selected from the following:

3. A pharmaceutical composition comprising a compound of claim 1 in admixture with a pharmaceutically acceptable carrier.

4. The pharmaceutical composition of claim 3, wherein said composition is formulated for parenteral, transdermal, oral, subcutaneous, intrapulmonary, topical or intranasal administration.

5. A method for inhibiting sonic hedgehog signaling in a cell comprising contacting a cell with a compound of claim 1 thereby inhibiting sonic hedgehog signaling in the cell.

6. The method of claim 5, wherein said method is carried out in vitro.

7. The method of claim 5, wherein the cell is a cancer cell.

8. A method for treating cancer comprising administering to a subject in need of treatment an effective amount of the pharmaceutical composition of claim 3 thereby treating the subject'"'"'s cancer.

9. The method of claim 8, wherein the cancer is breast cancer, prostate cancer, small cell lung cancer, lung adenocarcinoma, melanoma, pancreatic cancer, basal cell carcinoma, medulloblastoma, or meningioma.

10. The method of claim 9, wherein the cancer has metastasized.