Orthovoltage radiotherapy

• US 8,761,336 B2
• Filed: 01/06/2012
• Issued: 06/24/2014
• Est. Priority Date: 10/16/2006
• Status: Active Grant

• Current Assignee: Carl Zeiss Meditec Incorporated (Carl-Zeiss-Stiftung)
• Original Assignee: Oraya Therapeutics, Inc.
• Inventors: Gertner, Michael
• Primary Examiner(s): Kao, Glen
• Application Number:
  US13/345,655
• Publication Number:
  US 20120177179A1
• Time in Patent Office: 900 Days
• Field of Search: 378/65
• US Class Current: 378/65
• CPC Class Codes: A61B 2017/306 holding by means of suction
• CPC Class Codes: A61B 6/506 for diagnosis of nerves
• CPC Class Codes: A61F 9/009 Auxiliary devices making contact with the eyeball and coupling in laser light, e.g. goniolenses apparatus for eye examination A61B3/0008
• CPC Class Codes: A61N 2005/105 using a laser alignment system
• CPC Class Codes: A61N 2005/1056 by projecting a visible image of the treatment field
• CPC Class Codes: A61N 2005/1091 Kilovoltage or orthovoltage range photons
• CPC Class Codes: A61N 5/1017 Treatment of the eye, e.g. for "macular degeneration"
• CPC Class Codes: A61N 5/103 Treatment planning systems
• CPC Class Codes: A61N 5/1049 for verifying the position of the patient with respect to the radiation beam

Abstract

Methods described herein include selecting a target disease having an associated therapeutic dose of radiation, determining a maximal energy in an x-ray radiation beam to be emitted from a radiotherapy system to deliver a therapeutic dose of radiation associated with the target disease to target tissue in a patient, the selected disease of the plurality of diseases requiring differing maximal energies of the x-ray radiation beam to achieve the associated therapeutic dose of radiation than the maximal energy required to achieve the associated therapeutic dose of radiation for another disease, and outputting to an output module an indication of the determined maximal energy. Methods carried out in a system that can include a processing module that receives an input including a selection of a target disease, and an output module, coupled to the processing module, that outputs, an indication of the determined maximal energy.

Claims

1. A method, for treating diseased tissue with radiation, comprising:

selecting a target disease from among a plurality of diseases, each of the plurality of diseases having an associated therapeutic dose of radiation;

determining, based on the target disease, a maximal energy in an x-ray radiation beam to be emitted from a radiotherapy system to deliver substantially the therapeutic dose of radiation associated with the target disease to target tissue in a patient;

wherein diseases of the plurality of diseases require differing maximal energies of the x-ray radiation beam to achieve the associated therapeutic dose of radiation than the maximal energy required to achieve the associated therapeutic dose of radiation for another disease of the plurality of diseases; and

outputting to an output module an indication of the determined maximal energy.

2. The method of claim 1, wherein the therapeutic dose of radiation associated with the target disease comprises a plurality of fractionated doses.

3. The method of claim 1, wherein the target disease affects an eye of the patient and the radiation beam is emitted toward the eye.

4. The method of claim 3, wherein the plurality of diseases comprises at least one of macular degeneration, a pterygium, an ocular tumor, diabetic retinopathy, glaucoma, and a premalignant lesion.

5. The method of claim 1, further comprising emitting x-ray radiation, based on the determined energy level, toward the target tissue to deliver a dose of radiation to the tissue.

6. The method of claim 5, further comprising collimating the radiation to a radiation beam having cross-sectional dimension of less than about 6 mm.

7. The method of claim 5, wherein the emitting comprises emitting a plurality of radiation beams toward the target tissue to deliver a dose of radiation to the tissue.

8. The method of claim 5, wherein the emitting comprises emitting x-ray radiation toward the target tissue to deliver a dose of radiation to the tissue.

9. The method of claim 8, wherein the emitting x-ray radiation comprises emitting a plurality of x-ray beams toward the tissue.

10. A system, for treating diseased tissue with radiation, comprising:

a processing module that receives an input, the input comprising a selection of a target disease from among a plurality of diseases, each of the plurality of diseases having an associated therapeutic dose of radiation, the processing module further determining, based on the target disease, a maximal energy in an x-ray radiation beam to be emitted from a radiotherapy system to deliver substantially the therapeutic dose of radiation associated with the target disease to target tissue in a patient;

wherein the maximal energy in the x-ray radiation beam is based on the selected target disease and beam energy attenuation due to any tissue overlying the target tissue; and

an output module, coupled to the processing module, that outputs, based on the input, an indication of the determined maximal energy.

11. The system of claim 10, further comprising the radiotherapy system, wherein the radiotherapy system is coupled to the output module and is configured to generate the radiation beam based on the indication of the determined maximal energy.

12. The system of claim 11, wherein the radiotherapy system comprises a power supply adapted to deliver between about 10 mA and about 800 mA of current to an anode of an x-ray tube that generates x-ray radiation.

13. The system of claim 12, wherein said anode is one of a stationary anode and a rotating anode.

14. The system of claim 12, wherein the radiotherapy system further comprises a collimator that collimates the x-ray radiation to an x-ray beam having a cross-sectional dimension of less than about 6 mm.

15. A method, for treating diseased tissue with radiation, comprising:

selecting a target disease from among a plurality of diseases, the plurality of diseases having associated therapeutic doses of radiation;

determining, based on the target disease, a maximal energy in an x-ray radiation beam to be emitted from a radiotherapy system to deliver substantially the therapeutic dose of radiation associated with the target disease to target tissue in a patient;

outputting to an output module an indication of the determined maximal energy; and

inputting a maximum voltage to an x-ray tube of the radiotherapy system to a value of between about 30 kV and about 300 kV, based on the determined maximal energy.

16. The method of claim 15, further comprising communicating the indication of the determined maximal energy from the output module to the radiotherapy system.

17. The method of claim 16, further comprising emitting the radiation beam, based on the indication of the determined maximal energy, from the radiotherapy system toward the target tissue.

18. The method of claim 17, further comprising collimating the x-ray beam with a collimator, such that the x-ray beam has a cross-sectional dimension of less than about 6 mm.

19. The method of claim 17, wherein the emitting comprises emitting a plurality of x-ray beams toward the target tissue to deliver fractionated doses of radiation to the tissue.

20. The method of claim 15, wherein the plurality of diseases comprises at least one of macular degeneration, a pterygium, an ocular tumor, diabetic retinopathy, glaucoma, and a premalignant lesion.